Expanding the Recessive Spectrum of Dilated Cardiomyopathy: RNA-Level Validation of a Homozygous CTNNA3 Splice-Site Variant.

CTNNA3 encodes αT-catenin, an intercalated disc (ICD) protein essential for cardiomyocyte coupling. Human omics studies have shown reduced CTNNA3 expression, ICD ultrastructural disruption, and dilate...

Explainable Machine Learning for Risk Prediction of Reduced Quality of Life in Hypertension.

BACKGROUND: Individuals with hypertension are at risk to reduced quality of life (QoL). Explainable machine learning (ML) can be used for domain-specific risk stratification and prioritization of modi...

Comparison of FINDRISC and the Framingham Model for Predicting CHD Risk: Results from the Kharameh Cohort Study.

BACKGROUND: Coronary heart disease is a leading cause of death worldwide, making early risk identification essential. This study compares the predictive performance of FINDRISC and the Framingham mode...

Associations Between Obesity-Related Comorbidities and Weight Loss After Bariatric Surgery: A Retrospective Analysis.

OBJECTIVE: The aim of the study was to describe the prevalence of comorbidities in patients with severe obesity in Poland and to assess the relationship between the diagnosis of chronic diseases and t...

Two-year real-world outcomes of coronary drug-coated balloon therapy: a retrospective comparative study of sirolimus- and paclitaxel-coated devices.

BACKGROUND: Drug-coated balloons (DCBs) represent a "leave-nothing-behind" strategy in percutaneous coronary intervention (PCI), particularly for small vessel disease and in-stent restenosis. However,...

Doppler Evaluation of Foetal Pulmonary Artery in Intrahepatic Cholestasis of Pregnancy: A Prospective Study.

BACKGROUND: Intrahepatic cholestasis of pregnancy (ICP) is the most prevalent liver disease specific to pregnancy, with higher incidence of adverse pregnancy outcomes. Keeping this in mind, this study...

Epidemiology and determinants of dyslipidemia in Iranian population: Results from the PERSIAN cohort.

BACKGROUND: Dyslipidemia is one of the main risk factors for cardiovascular diseases worldwide. The current study aimed to determine the prevalence and correlates of dyslipidemia in Iran, in addition ...

Effectiveness of combined exercise training for hypertension management: a systematic review and meta-analysis of randomized controlled trials.

INTRODUCTION: hypertension is a leading global health issue with poor control despite pharmacological treatments. Combined exercise is a promising non-pharmacological strategy. This systematic review ...

Immunological coagulation dual axis stratification identifies ultra high-risk phenotypes in systemic sclerosis.

OBJECTIVE: Systemic sclerosis is a heterogeneous autoimmune disease characterized by complex interplay among immune activation, inflammation, coagulation, and fibrinolysis. This study aimed to constru...

Association Between Telemedicine Use and Outpatient Visits Among Hypertensive Patients With Disabilities During COVID-19.

BackgroundThe Korean government allowed for the temporary provision of non-face-to-face healthcare services (telemedicine) from 24 February 2020, due to the widespread outbreak of coronavirus disease ...

A novel dynamic Optuna hybrid Harris Hawks Optimization approach for classification of CAD.

Coronary Artery Disease (CAD) is a leading cause of mortality worldwide and is primarily associated with atherosclerotic plaque formation, resulting in coronary artery stenosis. The accurate predictio...

The pharmacist's role in the periprocedural management of anticoagulation in Canada: A qualitative study protocol.

Anticoagulants are crucial for both the immediate and ongoing management of thromboembolic disorders, including atrial fibrillation and venous thromboembolism, and for patients with mechanical heart v...

Rates and predictors of hospital visits after "Possible AF" alerts from a home ECG monitor in older adults with hypertension: A sub-analysis of the Omron Heart Study.

BACKGROUND: Home ECG can detect atrial fibrillation (AF), but patients' hospital visit behavior after "possible AF" alerts remains uncertain. We assessed the rates, timing, and correlates of hospital ...

Association of the combined triglyceride glucose-body mass index and serum IQGAP3 in appraising coronary lesion severity in type 2 diabetes.

BACKGROUND: IQGAP3 is a novel scaffold protein involved in inflammatory and metabolic regulation and may contribute to atherosclerosis. However, its clinical significance in coronary artery disease am...

Magnetocardiography for Exploratory Risk Stratification in Patients With Three-Vessel Coronary Artery Disease: A Single-Center Prospective Cohort Study.

BACKGROUND AND AIMS: Patients with three-vessel coronary artery disease (3V-CAD) remain at heterogeneous risk for major adverse cardiovascular and cerebrovascular events (MACCE) after revascularizatio...

Insulin resistance as a predictor of long-term adverse cardiovascular event risk in patients with atrial fibrillation following radiofrequency catheter ablation.

BACKGROUND: Catheter ablation is the first-line therapy for atrial fibrillation (AF), yet a significant proportion of patients experience major adverse cardiovascular events (MACEs) post-ablation, hig...

Macrophage migration inhibitory factor in atrial fibrillation.

Macrophage migration inhibitory factor (MIF) is a multifunctional upstream cytokine that has attracted increasing attention for its role in the initiation and perpetuation of atrial fibrillation (AF)....

[Caseous mitral annulus calcification: a case report].

Caseous calcification of the mitral annulus is a rare entity, often unrecognised by clinicians and radiologists alike. It can be difficult to diagnose on echocardiography, with the risk of confusion w...

Exercise-conditioned extracellular vesicles in Alzheimer's disease: a multi-organ signaling network linking peripheral adaptation to brain pathology.

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder in which amyloid-β accumulation, tau pathology, chronic neuroinflammation, cerebrovascular impairment, and synaptic dysfunction ...

Potential Diagnostic and Therapeutic Uses of DPT in Acute Type A Aortic Dissection.

PURPOSE: Acute Type A aortic dissection (ATAAD) is a catastrophic cardiovascular emergency with high mortality and few treatment options. Diagnostic biomarkers or targeted treatments remain in the rud...