Macrophage migration inhibitory factor in atrial fibrillation.

Macrophage migration inhibitory factor (MIF) is a multifunctional upstream cytokine that has attracted increasing attention for its role in the initiation and perpetuation of atrial fibrillation (AF)....

[Caseous mitral annulus calcification: a case report].

Caseous calcification of the mitral annulus is a rare entity, often unrecognised by clinicians and radiologists alike. It can be difficult to diagnose on echocardiography, with the risk of confusion w...

Exercise-conditioned extracellular vesicles in Alzheimer's disease: a multi-organ signaling network linking peripheral adaptation to brain pathology.

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder in which amyloid-β accumulation, tau pathology, chronic neuroinflammation, cerebrovascular impairment, and synaptic dysfunction ...

Potential Diagnostic and Therapeutic Uses of DPT in Acute Type A Aortic Dissection.

PURPOSE: Acute Type A aortic dissection (ATAAD) is a catastrophic cardiovascular emergency with high mortality and few treatment options. Diagnostic biomarkers or targeted treatments remain in the rud...

Research progress on targeted regulatory proteins in the prevention and treatment of atherosclerosis.

Atherosclerosis (AS) is a chronic inflammatory disease characterized by lipid metabolic dysregulation and vascular cell phenotypic switching. Its progression is governed by intricate interactions betw...

Waist circumference versus BMI: A cross-sectional study comparing Cardiometabolic Risk association in the Nepalese Population.

BACKGROUND: Obesity is a major cardiometabolic risk factor. Although body mass index (BMI) and waist circumference (WC) are established predictors of cardiometabolic risk, their predictive value may v...

The oral and lower airway microbiota and coronary heart disease in COPD patients and controls.

BACKGROUND: Chronic obstructive pulmonary disease (COPD) and coronary heart disease (CHD) are major causes of morbidity and mortality, with shared risk factors and often co-occurring. This study inves...

Safety and Feasibility of a Simplified Perioperative Hemodialysis Protocol in Hemodialysis Patients Undergoing Off-Pump Coronary Artery Bypass Grafting.

PURPOSE: Patients on hemodialysis (HD) undergoing coronary artery bypass grafting (CABG) face a high risk of perioperative complications, and the optimal timing of perioperative HD remains unclear. We...

The role of the NLRP3 inflammasome in hypertension-related chronic heart failure and its potential therapeutic targets.

BACKGROUND: Hypertension-induced pressure overload is a major driver of chronic heart failure (CHF) and is accompanied by persistent sterile inflammation. However, the upstream mechanisms linking mech...

Development and Validation of a Nomogram for Estimating Stroke Risk in Nonvalvular Atrial Fibrillation Patients With Left Atrial Stiffness: A Single-Center Cross-Sectional Study.

BACKGROUND: Nonvalvular atrial fibrillation (NVAF) is a prevalent arrhythmia associated with an increased risk of ischemic stroke. This study is aimed at assessing the clinical significance of echocar...

Balancing Beats and Bleeding: The Evolving Landscape of Atrial Fibrillation and Anticoagulation in the Past Two Decades.

BackgroundAnticoagulation has been the cornerstone for stroke prevention in patients with atrial fibrillation (AF). This study aims to describe the research trends and research hotspots in anticoagula...

Single-point insulin sensitivity estimator and atrial fibrillation: association and incremental discriminative value in a hospital-based population.

BACKGROUND: The single-point insulin sensitivity estimator (SPISE), derived from triglycerides, high-density lipoprotein cholesterol, and body mass index, has emerged as an easily calculated marker of...

Electrophysiological Modeling and Molecular Dynamics Simulations of Cardiac Sodium Channels in Brugada Syndrome.

Brugada syndrome (BrS) is a rare but potentially fatal genetic cardiac disorder, primarily caused by mutations in sodium and potassium ion channels, leading to ventricular arrhythmias and sudden cardi...

Double-staged thromboembolectomy in acute visceral ischemia with atypical origin of right hepatic artery, complicated by secondary intestinal infiltrate.

INTRODUCTION: Acute mesenteric ischemia is a rare but serious vascular complication often accompanied by intestinal damage. Treatment typically involves surgical and endovascular procedures. Proper di...

Rapidly progressive popliteal artery aneurysm with fistula into the venous system as a rare complication of infective endocarditis.

INTRODUCTION: Infective endocarditis (IE) is a serious disease with a high mortality rate. Complications of IE are frequent and serious, most of them manifesting as various forms of ischemia. Its rare...

Asprosin Protects H9C2 Cells From Ferroptosis Following Hypoxia/Reoxygenation by Promoting Mitophagy.

BACKGROUND: Acute myocardial infarction is a leading cause of death globally. Percutaneous coronary intervention is the primary treatment to restore blood flow to the affected myocardium, but reperfus...

Effects of captopril and losartan on early wound healing in hypertensive rats.

PURPOSE: To compare the effects of captopril and losartan on inflammatory response, angiogenesis, and fibroblast activity during the early phase of wound healing in hypertensive rats. METHODS: Twenty-...

Multi‑feature Prediction Model for Coronary Heart Disease Comorbidity in Middle‑aged and Older Adults with COPD Based on Machine Learning and SHAP.

BACKGROUND: Chronic obstructive pulmonary disease (COPD) frequently coexists with coronary heart disease (CHD), markedly worsening prognosis in middle-aged and older patients. Early identification of ...

Vancomycin-impregnated decellularized bovine pericardium membranes coating silicone implants: in-vivo biocompatibility and antibacterial efficacy in a rat model.

PURPOSE: To evaluate the inflammatory response, fibrotic encapsulation, tissue integration, and antibacterial effectiveness of silicone implants coated with decellularized bovine pericardium membranes...

Repair of Membranous Tracheal Defect Using Sutureless Free Pericardial Fat Pad Covering During Endoscopic Resection of Tracheal Mucus Retention Cyst: A Case Report.

A man in his 60s was referred to our hospital for evaluation of a cystic nodule on the membranous trachea detected on computed tomography. Bronchoscopy revealed a submucosal nodule. After dissecting t...