Research progress on targeted regulatory proteins in the prevention and treatment of atherosclerosis.

Atherosclerosis (AS) is a chronic inflammatory disease characterized by lipid metabolic dysregulation and vascular cell phenotypic switching. Its progression is governed by intricate interactions betw...

Waist circumference versus BMI: A cross-sectional study comparing Cardiometabolic Risk association in the Nepalese Population.

BACKGROUND: Obesity is a major cardiometabolic risk factor. Although body mass index (BMI) and waist circumference (WC) are established predictors of cardiometabolic risk, their predictive value may v...

The oral and lower airway microbiota and coronary heart disease in COPD patients and controls.

BACKGROUND: Chronic obstructive pulmonary disease (COPD) and coronary heart disease (CHD) are major causes of morbidity and mortality, with shared risk factors and often co-occurring. This study inves...

Safety and Feasibility of a Simplified Perioperative Hemodialysis Protocol in Hemodialysis Patients Undergoing Off-Pump Coronary Artery Bypass Grafting.

PURPOSE: Patients on hemodialysis (HD) undergoing coronary artery bypass grafting (CABG) face a high risk of perioperative complications, and the optimal timing of perioperative HD remains unclear. We...

The role of the NLRP3 inflammasome in hypertension-related chronic heart failure and its potential therapeutic targets.

BACKGROUND: Hypertension-induced pressure overload is a major driver of chronic heart failure (CHF) and is accompanied by persistent sterile inflammation. However, the upstream mechanisms linking mech...

Development and Validation of a Nomogram for Estimating Stroke Risk in Nonvalvular Atrial Fibrillation Patients With Left Atrial Stiffness: A Single-Center Cross-Sectional Study.

BACKGROUND: Nonvalvular atrial fibrillation (NVAF) is a prevalent arrhythmia associated with an increased risk of ischemic stroke. This study is aimed at assessing the clinical significance of echocar...

Balancing Beats and Bleeding: The Evolving Landscape of Atrial Fibrillation and Anticoagulation in the Past Two Decades.

BackgroundAnticoagulation has been the cornerstone for stroke prevention in patients with atrial fibrillation (AF). This study aims to describe the research trends and research hotspots in anticoagula...

Single-point insulin sensitivity estimator and atrial fibrillation: association and incremental discriminative value in a hospital-based population.

BACKGROUND: The single-point insulin sensitivity estimator (SPISE), derived from triglycerides, high-density lipoprotein cholesterol, and body mass index, has emerged as an easily calculated marker of...

Electrophysiological Modeling and Molecular Dynamics Simulations of Cardiac Sodium Channels in Brugada Syndrome.

Brugada syndrome (BrS) is a rare but potentially fatal genetic cardiac disorder, primarily caused by mutations in sodium and potassium ion channels, leading to ventricular arrhythmias and sudden cardi...

Double-staged thromboembolectomy in acute visceral ischemia with atypical origin of right hepatic artery, complicated by secondary intestinal infiltrate.

INTRODUCTION: Acute mesenteric ischemia is a rare but serious vascular complication often accompanied by intestinal damage. Treatment typically involves surgical and endovascular procedures. Proper di...

Rapidly progressive popliteal artery aneurysm with fistula into the venous system as a rare complication of infective endocarditis.

INTRODUCTION: Infective endocarditis (IE) is a serious disease with a high mortality rate. Complications of IE are frequent and serious, most of them manifesting as various forms of ischemia. Its rare...

Asprosin Protects H9C2 Cells From Ferroptosis Following Hypoxia/Reoxygenation by Promoting Mitophagy.

BACKGROUND: Acute myocardial infarction is a leading cause of death globally. Percutaneous coronary intervention is the primary treatment to restore blood flow to the affected myocardium, but reperfus...

Effects of captopril and losartan on early wound healing in hypertensive rats.

PURPOSE: To compare the effects of captopril and losartan on inflammatory response, angiogenesis, and fibroblast activity during the early phase of wound healing in hypertensive rats. METHODS: Twenty-...

Multi‑feature Prediction Model for Coronary Heart Disease Comorbidity in Middle‑aged and Older Adults with COPD Based on Machine Learning and SHAP.

BACKGROUND: Chronic obstructive pulmonary disease (COPD) frequently coexists with coronary heart disease (CHD), markedly worsening prognosis in middle-aged and older patients. Early identification of ...

Vancomycin-impregnated decellularized bovine pericardium membranes coating silicone implants: in-vivo biocompatibility and antibacterial efficacy in a rat model.

PURPOSE: To evaluate the inflammatory response, fibrotic encapsulation, tissue integration, and antibacterial effectiveness of silicone implants coated with decellularized bovine pericardium membranes...

Repair of Membranous Tracheal Defect Using Sutureless Free Pericardial Fat Pad Covering During Endoscopic Resection of Tracheal Mucus Retention Cyst: A Case Report.

A man in his 60s was referred to our hospital for evaluation of a cystic nodule on the membranous trachea detected on computed tomography. Bronchoscopy revealed a submucosal nodule. After dissecting t...

Treatment of mild subclinical hypothyroidism and its impact on lipid metabolism.

BACKGROUND: Hypothyroidism, both overt and subclinical, is associated with dyslipidemia and increased cardiovascular risk which is not completely corrected by thyroid hormone replacement therapy. In p...

Elevated Hydrocarbon Exposure Escalates Coronary and Cerebrovascular Disease Risks: A Comprehensive Systematic Review.

Exposure to hydrocarbons, including polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs), represents an escalating public health concern. These compounds induce systemic infla...

Topographic anatomy and anatomic morphometry of abdominal aorta and renal artery versus atherosclerotic plaque formation: apples and pears?

OBJECTIVE: The aim of this retrospective study was to evaluate the relationship between renal artery morphometry and renal artery plaque formation and location using multislice computed tomography ang...

When Anatomy Meets Pathology: May-Thurner Syndrome as an Underdiagnosed Cause of Acute DVT.

May-Thurner Syndrome (MTS) is an underrecognized anatomic cause of left-sided deep vein thrombosis (DVT) resulting from compression of the left common iliac vein by the overlying right common iliac ar...