Treatment of mild subclinical hypothyroidism and its impact on lipid metabolism.

BACKGROUND: Hypothyroidism, both overt and subclinical, is associated with dyslipidemia and increased cardiovascular risk which is not completely corrected by thyroid hormone replacement therapy. In p...

Elevated Hydrocarbon Exposure Escalates Coronary and Cerebrovascular Disease Risks: A Comprehensive Systematic Review.

Exposure to hydrocarbons, including polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs), represents an escalating public health concern. These compounds induce systemic infla...

Topographic anatomy and anatomic morphometry of abdominal aorta and renal artery versus atherosclerotic plaque formation: apples and pears?

OBJECTIVE: The aim of this retrospective study was to evaluate the relationship between renal artery morphometry and renal artery plaque formation and location using multislice computed tomography ang...

When Anatomy Meets Pathology: May-Thurner Syndrome as an Underdiagnosed Cause of Acute DVT.

May-Thurner Syndrome (MTS) is an underrecognized anatomic cause of left-sided deep vein thrombosis (DVT) resulting from compression of the left common iliac vein by the overlying right common iliac ar...

Automated segmentation of pituitary adenomas, pituitary gland, and internal carotid arteries on routine coronal contrast-enhanced T1-weighted MRI: a single-sequence feasibility study.

INTRODUCTION: Pituitary adenomas (PAs) alter the anatomy of the pituitary gland (PG) and internal carotid arteries (ICAs), requiring accurate segmentation for surgical planning and risk assessment. Mu...

Association of the Endothelial Activation and Stress Index with Mortality in Critically Ill Patients with Chronic Obstructive Pulmonary Disease: A Retrospective Cohort Study.

BACKGROUND: In view of the established role of endothelial dysfunction in the pathophysiology of chronic obstructive pulmonary disease (COPD), the Endothelial Activation and Stress Index (EASIX), a va...

A human 3D BBB chip model of acute stroke simulating a reversible penumbra.

Ischemic stroke is a leading cause of mortality and disability worldwide. However, existing models often fail to replicate key aspects of human pathophysiology, particularly blood-brain barrier (BBB) ...

Perfusion imaging findings, and outcomes between computed tomography perfusion selected basilar artery occlusion and anterior circulation stroke patients undergoing endovascular treatment.

BACKGROUND: Basilar artery occlusion (BAO) is a severe form of ischemic stroke associated with high morbidity and mortality. Whether BAO patients derive similar benefits from CT perfusion (CTP)-guided...

A One-Year Retrospective Observational Study Reveals the Transient Nature of Pemafibrate-Induced LDL-C Elevation: Implications Beyond the PROMINENT Trial.

PURPOSE: Pemafibrate, a selective peroxisome proliferator-activated receptor-α modulator (SPPARMα), is widely used for hypertriglyceridemia; however, concerns persist regarding its potential to elevat...

Muscle Ultrasound Parameters and Cognitive Function in H‑type Hypertension: A Cross-Sectional Study.

BACKGROUND: H-type hypertension is associated with an increased risk of cognitive impairment, but the relationship between muscle ultrasound parameters and cognitive function in this population remain...

Impact of Obesity on the Association Between Salt Intake and Blood Pressure in Adult Men With Hypertension Who Participated in the Remote Lifestyle Intervention.

INTRODUCTION: Experimental studies have demonstrated that obesity increases salt sensitivity, defined as the blood pressure (BP) response to salt intake; however, its relevance within real-world lifes...

Association of serum 25-hydroxyvitamin D levels with indicators of target organ damage in patients with diabetes: a cross-sectional study.

OBJECTIVE: To assess serum 25-hydroxyvitamin D [25(OH)D] in relation to indicators of target organ damage in patients with diabetes. METHODS: This analysis included 372 adults with diabetes who underw...

Diagnostic Accuracy of Anti-factor Xa Activity, PT, and APTT for Clinically Relevant Rivaroxaban Levels in Older AF Patients.

BackgroundRapid assessment of rivaroxaban exposure is clinically critical for older patients with atrial fibrillation in scenarios such as acute bleeding, urgent invasive procedures, or thrombolysis d...

Resting energy expenditure under fasting conditions is primarily explained by fat-free mass rather than cardiac autonomic markers.

BACKGROUND: Resting Energy Expenditure (REE) represents the largest component of total daily energy expenditure. While fat-free mass (FFM) is its primary predictor, substantial interindividual variabi...

Targeted Delivery of Schisandrin A to Cardiac Endothelium Alleviates Myocardial Ischemia-Reperfusion Injury via Suppression of Ferroptosis.

PURPOSE: Myocardial microvascular injury plays a critical role in myocardial ischemia‑reperfusion injury (MI/RI), and ferroptosis has emerged as an important contributor to cardiac damage. Although Sc...

BIRC3-CASP8 axis orchestrates the PANoptosis spectrum: taming the inflammatory storm to prevent post-ischemic heart failure.

BACKGROUND: The progression of heart failure (HF) following myocardial ischemia/reperfusion (I/R) injury is driven by regulated cell death. Unlike the restrained nature of apoptosis, pyroptosis and ne...

Crosstalk in Alzheimer's-delirium nexus: Molecular mechanisms and therapeutic repurposing.

Alzheimer's disease (AD) and delirium, though distinct in clinical tempo, converge mechanistically at the intersection of neurovascular dysfunction, glial activation, and metabolic collapse. This chap...

Mitochondrial DNA efflux as a potential amplifier of systemic inflammatory network rewiring in heart failure with preserved ejection fraction.

Heart failure with preserved ejection fraction (HFpEF) is a systemic inflammatory disease that affects multiple organs. However, the integration of different comorbid stress factors into a persistent ...

Predicting heart failure in asymptomatic diabetes: derivation and internal validation of a clinical prediction model for early detection of diabetic cardiomyopathy.

OBJECTIVE: To develop and internally validate a clinical prediction model for identifying asymptomatic type 2 diabetes (T2DM) patients at risk of incident heart failure (HF) or progression of subclini...

Targeting Aldosterone Biosynthesis in Uncontrolled and Resistant Hypertension: A Systematic Review and Meta-Analysis of Randomized Trials of Lorundrostat and Baxdrostat.

BackgroundAldosterone excess contributes to uncontrolled and resistant hypertension, making aldosterone synthase inhibition a promising therapeutic strategy. Recent randomized trials have evaluated th...