Prevalence and Associated Factors of Frailty in Middle-Aged and Elderly Patients with Atrial Fibrillation: An Exploratory Machine Learning Analysis.

BACKGROUND: Frailty significantly increases the risk of adverse outcomes in patients with atrial fibrillation (AF), particularly among middle-aged and elderly individuals. Despite its clinical importa...

Matrix metalloproteinase activation and TNF upregulation characterize the sclerotic phase of aortic valve disease.

INTRODUCTION: Aortic valve sclerosis (AVSc) is an active pathological process driven by extracellular matrix remodeling, consistent with a potentially reversible early stage of aortic valve disease. M...

Circulating cytokines as triggers of endothelial dysfunction and sex-specific interstitial cell response in fibrocalcific aortic valve disease.

BACKGROUND: Fibrocalcific aortic valve disease (FCAVD) is a progressive and multifactorial pathology that remains asymptomatic in its early stages and lacks effective pharmacological therapies. Aortic...

Efficacy of Steroid Therapy in Preventing Adverse Clinical Outcomes in Patients with Fulminant Myocarditis Requiring Mechanical Circulatory Support.

There is limited data about the efficacy of steroid therapy in preventing adverse clinical outcomes in fulminant myocarditis requiring mechanical circulatory support (MCS). This study aimed to evaluat...

Clinical Impact of Cardiac Arrest in Patients with Fulminant Myocarditis Requiring Veno-Arterial Extracorporeal Membrane Oxygenation.

Fulminant myocarditis (FM) is characterized by rapid hemodynamic deterioration and is often accompanied by cardiac arrest (CA). Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is frequentl...

CD73 activity controls cytotoxic CD4 T-cell response driving myocardial pathology in chronic Chagas disease.

Chagas disease, caused by Trypanosoma cruzi, is the major cause of infectious cardiopathology worldwide. Although cytotoxic CD4 T-cells (CD4 CTLs) have recently been recognized as crucial effectors in...

Modeling Hypertrophic Cardiomyopathy-Related MYH7 Variants: Insights into Structural Changes and Cardiovascular Drug-Binding Affinities.

Mutations in the MYH7 gene, which encodes β-myosin heavy chain (β-MHC), are a significant cause of hypertrophic cardiomyopathy (HCM). These variants may lead to variable clinical outcomes, thereby inf...

Screening and comprehensive analysis of endoplasmic reticulum stress-related biomarkers in atherosclerosis.

Atherosclerosis (AS) is a chronic inflammatory vascular disorder in which endoplasmic reticulum stress (ERS) plays a crucial regulatory role. However, the biological and translational relevance of ERS...

BMI-specific nonlinear associations and threshold effects of the atherogenic index of plasma on incident prediabetes: insights from 100473 Chinese adults.

BACKGROUND: Emerging evidence suggests that the atherogenic index of plasma (AIP), a simple marker of lipid-related metabolic risk, may relate to dysglycemia in a nonlinear fashion. However, whether t...

Gut microbiota dysbiosis-induced chronic inflammation as a driver of atherosclerosis: cellular crosstalk and host-microbe interactions.

Gut microbiota dysbiosis is increasingly recognized as an upstream contributor to chronic low-grade inflammation and atherosclerosis (AS). Disruption of microbial homeostasis may impair intestinal bar...

Association between Serum Neurofilament Light Chain Levels and the Predicted 10-Year Atherosclerotic Cardiovascular Disease Risk.

This cross-sectional study aimed to examine the association between serum neurofilament light chain (sNfL) and the PCE-estimated 10-year atherosclerotic cardiovascular disease (ASCVD) score using data...

Cost-effectiveness of inclisiran in patients with atherosclerotic cardiovascular disease from Chinese healthcare perspective.

BACKGROUND: Atherosclerotic cardiovascular disease (ASCVD) imposes a substantial clinical and economic burden in China. Despite maximally tolerated statin therapy, many patients fail to achieve recomm...

Neutrophil extracellular traps and pyroptosis: a molecular nexus linking systemic autoimmune diseases to atherosclerosis.

This review aims to elucidate the molecular mechanisms of neutrophil extracellular traps (NETs) and pyroptosis, exploring their synergistic role as a pathological nexus bridging systemic autoimmune di...

Glycolysis and neutrophil extracellular traps in atherosclerosis: Mechanisms, association, and therapeutic strategies.

Atherosclerosis (AS) is a chronic inflammatory disorder of the medium and large arteries, characterized by lipid accumulation within the arterial wall and a sustained inflammatory milieu, and it remai...

Associations between systemic inflammation, nutritional status, and cardiometabolic diseases and risk factors among adults living in transitional rural communities in Ecuador.

BACKGROUND: Chronic low-grade systemic inflammation, as indicated by elevated high-sensitivity C-reactive protein (hs-CRP), has been implicated in the pathogenesis of cardiometabolic diseases. Less is...

Know Your Number; Control Your Number campaign: Nigeria.

INTRODUCTION: Know Your Numbers; Control Your Numbers is a landmark nationwide health initiative designed to screen 10 million Nigerians for risk factors associated with non-communicable diseases (NCD...

Economic vulnerability or social inequality? A global comparative analysis of their relative impact on chronic kidney disease burden.

PURPOSE: To compare the impacts of persistent social inequality (Palma ratio) and conjunctural economic vulnerability (unemployment) on chronic kidney disease (CKD) burden and to test whether hyperten...

[Pulmonary Arterial Hypertension Impairs Duodenal Barrier Integrity in Rats].

Pulmonary arterial hypertension (PAH) is a progressive pulmonary vascular disease that leads to right heart failure and systemic venous congestion. Such congestion can impair multiple organs, includin...

Impact of gestational diabetes mellitus and hypertensive disorders of pregnancy on adverse pregnancy outcomes: a retrospective cohort study.

OBJECTIVE: To investigate the independent and joint effects of gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP) on adverse pregnancy outcomes, evaluate their potential...

Development and external validation of an interpretable machine learning model for diagnosing coronary heart disease in patients with type 2 diabetes and MASLD.

INTRODUCTION: Patients with type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated steatotic liver disease (MASLD) face substantially elevated coronary heart disease (CHD) risk, yet no m...