Qualitative and Quantitative Prediction of Blood-Brain Barrier Permeability of Chemicals via an SE(3)-Transformer-Based Model with LLM-Assisted Explanation.

The blood-brain barrier (BBB) regulates the entry of chemicals into the central nervous system, and contaminants with high permeability can accumulate in the brain, posing neurotoxicity risks. Given t...

Clinical Relevance of Serum Inducible and Endothelial Nitric Oxide Synthase Ratio for Pulmonary Hypertension in Acute Exacerbated Chronic Obstructive Pulmonary Disease.

BACKGROUND: Pulmonary hypertension (PH) is a common complication of acute exacerbated chronic obstructive pulmonary disease (AECOPD) and is associated with poor prognosis. Nitric oxide synthase (NOS) ...

Inhibition of RBM25 preserves cardiac mitochondrial homeostasis and attenuates ischemic heart failure.

Heart failure (HF) after myocardial infarction (MI) is a serious complication that endangers the health of the patient. Mitochondrial dysfunction is an important mechanism in the development of ischem...

GLSP ameliorates monocrotaline-induced pulmonary arterial hypertension through inhibition of the PI3K/AKT and MAPK signaling pathways.

Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling and right heart dysfunction, driven largely by excessive proliferation of pulmonary arterial smooth muscle cells...

Potassium-Selective Nanoelectrode Arrays for Single-Cell Profiling of Human iPSC-Derived Cardiomyocytes.

Potassium ion (K+) dynamics are central to cardiac electrophysiology, with early disruptions in K+ flux often preceding arrhythmia and contractile dysfunction. However, current sensing technologies, s...

Topographic anatomy of suprascapular artery branches in the supraspinatus fossa: surgical implications for rotator cuff and muscle advancement.

PURPOSE: The suprascapular artery (SSA) is the main vascular supply to the rotator cuff musculature, but its detailed branching pattern in the supraspinatus fossa and clinical relevance for surgery an...

The evolving role of computed tomography angiography in superficial circumflex iliac artery perforator flap mapping from anatomy to surgery: a systematic review.

PURPOSE: The reliable application of the superficial circumflex iliac artery perforator (SCIP) flaps is frequently hindered by significant anatomical variability in its vascular supply. Preoperative m...

Cellular crosstalk between endothelial and vascular smooth muscle cells via the BACH1/COL3A1 axis promotes vascular calcification in chronic kidney disease.

BACKGROUND: High phosphate levels lead to significant pathological changes in vascular smooth muscle cells (VSMCs) and endothelial cells, driving vascular disease in chronic kidney disease (CKD). Endo...

GPR132 antagonists alleviate atherosclerosis by suppressing M1 polarization and subsequent VSMCs proliferation and migration as revealed by transcriptomic profiling.

BACKGROUND: Atherosclerosis (AS) is a chronic inflammatory disorder with substantial global prevalence, wherein macrophage polarization and vascular smooth muscle cells (VSMCs) phenotypic switching ar...

Overcoming the blood-brain barrier using central nervous system-accessing lipid nanoparticles for enhanced mRNA therapeutics.

Messenger RNA (mRNA) therapeutics hold potential for central nervous system (CNS) disease treatment. However, the blood-brain barrier (BBB) presents a major obstacle, preventing efficient delivery of ...

[Efficacy of rescue extracorporeal membrane oxygenation combined with delayed left ventricular assist device implantation for in-hospital sudden cardiac arrest in end-stage heart failure patients].

The data of eight patients with end-stage heart failure who experienced in-hospital sudden cardiac arrest and received cardiopulmonary resuscitation (CPR), followed by extracorporeal membrane oxygenat...

AAV-NRF2 protects retinal and choroidal vasculature in a GDF15-dependent manner in an oxidative damage model of AMD.

Oxidative stress is proposed to be a driver of age-related diseases. Age-related macular degeneration (AMD) is one such disease, where the retinal pigment epithelium (RPE) is affected early in the dis...

Two Faces of the Right Ventricle in Fabry Cardiomyopathy: Septal-Coupled and Atrial-Coupled Strain Patterns and Their Differential Associations with Enzyme Replacement Therapy.

Right ventricular global longitudinal strain (RVGLS) and right ventricular free-wall longitudinal strain (RVFWLS) are both used to assess right ventricular involvement, but they include different myoc...

Induced Pluripotent Stem Cell-Based Platforms for Cardiac-Related Pain Research: Molecular Mechanisms, Experimental Models, and Therapeutic Applications.

Cardiac-related pain, including angina pectoris and pain accompanying myocardial infarction, remains clinically important, and existing treatments are inadequate for some patients. Animal and primary-...

Cerebral Intramural Cells: A Missing Cellular Link Between Vascular Aging and Alzheimer's Disease.

The pathological deposition of amyloid-β (Aβ) in the walls of cerebral blood vessels as cerebral amyloid angiopathy (CAA) is a key feature of Alzheimer's disease (AD) and is linked to impaired clearan...

FHL3 Regulates Vascular Smooth Muscle Cell Phenotypic Switching Through the MRTFB-SRF Signaling Axis.

Genome-wide association studies have uncovered many coronary artery disease (CAD) loci, but mechanisms linking risk variants to vascular biology remain unclear. We screen candidate causal CAD genes fo...

Retrospective Evaluation of an AI-Based Computer-Aided Detection Algorithm for Lung Cancer Detection on Cardiac CT: A Multicenter Study.

BACKGROUND: To investigate the effectiveness of an artificial intelligence (AI)-based computer-aided detection (CAD) system in identifying incidental lung cancer on cardiac computed tomography (CT) sc...

Characteristics and outcomes of spontaneous coronary artery dissection of the left anterior descending artery.

BACKGROUND: Spontaneous coronary artery dissection (SCAD) is an underrecognised cause of acute coronary syndrome (ACS). The left anterior descending artery (LAD) is most frequently affected, but the c...

Outcomes of patients with large anatomies undergoing transcatheter tricuspid valve replacement with the LuX-Valve Plus system.

BACKGROUND: Transcatheter tricuspid valve replacement (TTVR) is increasingly performed to treat patients with severe or greater symptomatic tricuspid regurgitation (TR) at high risk for surgery. Howev...

CKLF1 Serves as a Pivotal Mediator of Blood-Brain Barrier Disruption and Neuroinflammation via PI3K/AKT/mTOR Signaling in Ischemic Stroke.

Ischemic stroke (IS) is accompanied by blood-brain barrier (BBB) disruption and neuroinflammatory activation, but the upstream regulatory mechanisms remain incompletely defined. Here, integrated singl...