Putative Modulation of OATP1A2 and P-gp Expression at the Blood-Brain Barrier by Nrf2-PXR: An Associative Hypothesis for Amyloid-β Transport in Alzheimer's Disease.

Impaired amyloid-β (Aβ) clearance across the blood-brain barrier (BBB) is a major contributor to Aβ accumulation in Alzheimer's disease (AD). P-glycoprotein (P-gp) has been identified as a key BBB eff...

From Valve Disease to Valve Replacement: Lipoprotein(a) Is Associated with Aortic Stenosis Severity but Not Prognosis After TAVI.

Background: Lipoprotein(a) [Lp(a)] has emerged as a key mediator of calcific aortic valve disease and is strongly linked to the development and progression of aortic stenosis (AS). Whether elevated Lp...

Mitral valve vegetations in an elderly patient with acute myeloid leukemia: navigating the overlap between infection and malignancy: a case report.

BACKGROUND: Acute myeloid leukemia (AML) is a hematologic malignancy that can rarely manifest with clinical features resembling infective endocarditis (IE), particularly in elderly individuals. Non-ba...

Optical System for Assessment of Atrial and Ventricular Mechanics in Langendorff-perfused Mouse Hearts.

The mouse heart serves as a widely used model in cardiovascular research, facilitated by advances in engineering technologies. However, assessment of atrial and ventricular contractility remains chall...

Tail Artery Blood Sampling in Isoflurane Anesthetized Rats Reduces Stress and Improves Reliability.

This method describes blood sampling via the tail artery in isoflurane-anesthetized rats. The use of isoflurane minimizes defensive movements, thereby enabling a controlled, low-stress procedure for b...

TLR2 mediates cell cycle re-entry and survival of neonatal cardiomyocytes in response to injury.

Unlike adult hearts, neonatal hearts can regenerate and adapt to stress. To identify both cardioprotective and regenerative mechanisms, we compared activated genes and related signaling pathways in th...

Evaluating the reliability and quality of viral myocarditis educational content on TikTok and Bilibili: A cross-sectional content analysis.

Viral myocarditis (VM) affects over 1 million people yearly worldwide and may trigger arrhythmia, heart failure, or sudden death, bringing heavy clinical and economic burdens. TikTok and Bilibili are ...

Spatial decoupling of plaque and circulating immune programs defines a robust gene signature in atherosclerosis: A multi-cohort integrative analysis.

Atherosclerosis (AS) is driven by chronic vascular inflammation, yet the relationship between immune activity within atherosclerotic lesions and systemic immune signals in peripheral blood remains poo...

Global, regional, and national burden of chronic kidney disease attributable to dietary risks, 1990 to 2021: A systematic analysis for the Global Burden of Disease Study 2021.

Dietary risks are key modifiable contributors to chronic kidney disease (CKD) worldwide; however, their association with geographic or socioeconomic status remains underexplored. We aimed to quantify ...

Blood pressure and renal outcomes after renal denervation in patients with chronic kidney disease: A systematic review and meta-analysis.

BACKGROUND: This systematic review and meta-analysis aimed to evaluate the efficacy and safety of renal denervation (RDN) in patients with chronic kidney disease (CKD), including those with end-stage ...

The association between obesity indices and hypertension in adults with different glycemic status: A population-based cross-sectional study of the Bandare-Kong cohort.

Obesity and hypertension (HTN) frequently coexist with dysglycemia, yet it remains unclear whether general (BMI) versus central (waist circumference, WC) obesity indices show differential associations...

Trends in peripheral vascular disease-related mortality among U.S. adults with co-listed hypertension and type 2 diabetes, 1999-2023: A retrospective observational study.

Peripheral vascular disease (PVD) represents a major component of cardiovascular disease and is associated with substantial functional impairment and healthcare costs. However, long-term national tren...

Non-HDL-C to HDL-C ratio and risks of all-cause and cardiovascular mortality in patients with coronary heart disease and type 2 diabetes mellitus: Results from NHANES 2005 to 2018.

Dyslipidemia is a major contributor to adverse outcomes in patients with coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM). The non-high-density lipoprotein cholesterol to high-density ...

Effect of dual antiplatelet therapy on prognosis of patients with myocardial infarction with nonobstructive coronary artery disease: A meta-analysis.

BACKGROUND: The diverse pathogenic mechanisms of myocardial infarction with nonobstructive coronary artery disease (MINOCA) result in therapeutic difficulties. The purpose of this meta-analysis was to...

Modified pulmonary artery obstruction index for thrombolysis assessment in intermediate-risk pulmonary thromboembolism: A retrospective cohort study.

Acute non-high-risk pulmonary thromboembolism (PTE) is generally relieved within months of anticoagulation treatment initiation. However, some patients experience complications. This study aimed to as...

Predictors of 1-year fibrosis in treatment-naïve neovascular age-related macular degeneration: the role of baseline OCTA-derived MNV vessel density.

BACKGROUND: To investigate baseline and post-loading optical coherence tomography angiography (OCTA) characteristics associated with 1-year fibrosis in treatment-naïve neovascular age-related macular ...

LncRNA DLX6-AS1 promotes necroptosis through PI3K/AKT/mTOR signaling pathway in myocardial ischemia/reperfusion injury mice.

Myocardial ischemia/reperfusion injury (MIRI) leads to life-threatening myocardial infarction. Necroptosis is involved in MIRI. The lncRNA DLX6-AS1 was found to participate in the context of MIRI. In ...

Novel triglyceride-lowering therapies to reduce the risk of acute pancreatitis in hypertriglyceridaemia: a protocol for systematic review and meta-analysis.

INTRODUCTION: Hypertriglyceridaemia is a major risk factor and rising aetiology for acute pancreatitis (AP), a condition associated with significant morbidity and mortality. Novel triglyceride-lowerin...

Plasma proteomics linking primary and secondary diseases: Insights into molecular mediation from UK Biobank data.

BACKGROUND: Diabetes, hypertension, and dyslipidemia are major risk factors for cardiovascular, neurological, renal, and pulmonary diseases, yet clinically accessible molecular mediators linking these...

Electrical cardioversion for atrial fibrillation: nationwide trends in Denmark, 2010-2022.

BACKGROUND: Electrical cardioversion (ECV) is widely used for restoring sinus rhythm in atrial fibrillation (AF). However, population-level trends in use of ECV in individuals with AF remain poorly ch...