Methadone administration and QT interval prolongation: protocol for a systematic review and meta-analysis.
INTRODUCTION: Methadone is a long-acting opioid used to treat opioid use disorder, cancer pain and provide perioperative analgesia. Methadone administration has been associated with QTc interval prolo...
Interplay of patent foramen ovale and atrial septum aneurysm in a nonagenarian patient presenting with platypnoea-orthodeoxia syndrome.
Patent foramen ovale (PFO) is a common congenital cardiac anomaly, generally responsible for cryptogenic stroke. Still, it can cause severe positional hypoxia via a right-to-left shunt if associated w...
HSP27 regulates force-coordinated DDR1 condensate disassembly and liquid-to-gel phase transition.
Endothelial cell (EC) mechanosensing is essential for vascular homeostasis and atherosclerosis development, though the influence of blood flow patterns on EC signaling is not fully understood. Discoid...
Endomyocardial Biopsies in the Diagnostic Workup of Immune Checkpoint Inhibitor Associated Myocarditis.
PURPOSE OF REVIEW: To identify the role of endomyocardial biopsy in the diagnosis, prognostication, and future understanding of mechanisms for immune checkpoint inhibitor myocarditis. RECENT FINDINGS:...
Object size-dependent bias in aortic valve calcium quantification: polychromatic images vs virtual monochromatic images.
OBJECTIVES: To compare aortic valve calcification (AVC) quantifications between polychromatic images (PI) and 70-keV virtual monochromatic images (VMI) obtained from photon-counting detector CT (PCD-C...
MicroRNAs in dilated cardiomyopathy: from biomarkers to therapeutic targets.
Dilated cardiomyopathy (DCM) remains a leading cause of non-ischemic heart failure and sudden cardiac death, with substantial heterogeneity in clinical presentation and outcomes. Conventional diagnost...
The regulatory network of Mfsd2a in cerebral ischemia: a novel time-targeted intervention framework.
Cerebral ischemia‒reperfusion injury disrupts blood-brain barrier (BBB) integrity, a process strongly linked to the downregulation of the lipid transporter Mfsd2a. Prior research has focused on the co...
A Rare Case of Takotsubo Cardiomyopathy Recurrence With Alternate Reverse Phenotypes.
BACKGROUND Takotsubo cardiomyopathy (TCM) is a stress-induced cardiomyopathy characterized by transient left ventricular systolic dysfunction and reversible regional wall-motion abnormalities extendin...
[Switch from STEMI to OMI].
Following up on a previous article written by Lindow et al, this article aims to further discuss a switch from STEMI to Occlusion Myocardial Infarction (OMI). The article explains how OMI can be diagn...
Rethinking atrial pacing support in cardiac resynchronization therapy: insights from the CRT-NEXT trial.
Cardiac resynchronization therapy defibrillators traditionally require a dedicated right atrial lead to provide atrial sensing and pacing in addition to biventricular pacing. However, the clinical val...
Native myocardial T1 reference values in a tunisian cohort using MOLLI and SMART1Map : List of Authors.
Native T1 values in cardiac magnetic resonance (CMR) are influenced by acquisition sequence, physiological factors, and site-specific variability, complicating clinical interpretation. The absence of ...
Shifting the Balance: Mitochondrial Heteroplasmy as a Driver of Cardiac Disease.
Mitochondrial heteroplasmy represents a fundamental determinant of mitochondrial function and disease, yet its consequences vary across different tissues. Although mitotic tissues possess mechanisms, ...
Surgical myectomy (SM), performed to relieve dynamic left ventricular outflow tract obstruction (LVOTO) in symptomatic obstructive hypertrophic cardiomyopathy (oHCM) patients provides improved quality...
Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder that affects cardiovascular, musculoskeletal, and ocular tissues, with premature death often resulting from dissection of the ...
A myocardial bridge (MB) can cause angina in patients with non-obstructive coronary arteries. For patients with a functionally significant MB and severe angina despite maximal medical therapy, surgica...
Although prompt primary percutaneous coronary intervention (PCI) reduces mortality in patients with ST-elevation myocardial infarction (STEMI), the burden of post-infarction heart failure remains cons...
The prevalence of mechanical complications following acute myocardial infarction has steadily declined in recent years owing to advances in prompt coronary revascularization, and they now occur in <1%...
A Potential Link Between Dyslipidemia and Inflammation in Patients with Schizophrenia: Insights from Sterols and HDL Profile Analysis.
Dyslipidemia and inflammation are two hallmarks of schizophrenia (SCZ), but the link between these two conditions remains elusive. We studied 40 SCZ patients and 40 age- and sex-matched healthy contro...
Corosolic Acid Induces Endothelium-Dependent Vasorelaxation in Isolated Rat Aortic Rings.
The effect of Corosolic acid (CA) on vascular tone and the possible mecha-nisms involved remain unclear. The SPF-grade male Sprague-Dawley rats (Animal Ethics Approval ID: USM/IACUC/2025/(155)(1406)) ...
Restoring autophagy-apoptosis balance in diabetic cardiomyopathy via a biomimetic, ROS-responsive nanocarrier associated with Mst1 pathway modulation.
Diabetic cardiomyopathy (DCM) is driven by oxidative stress and an imbalance between autophagy and apoptosis. To improve myocardial delivery of dimethyl fumarate (DMF), a known NRF2-activating redox m...