Systemic Inflammation and Outcomes After Mitral Edge-to-Edge Repair: Insights From the OCEAN-Mitral Registry.

BACKGROUND: Systemic inflammation is increasingly recognized as an important contributor to cardiovascular outcomes. High-sensitivity CRP (C-reactive protein) is an established biomarker, but its prog...

Role of Lipin-1 in Macrophage-Mediated Atherosclerosis: Is It Atherogenic or Atheroprotective?

Macrophages are central regulators of atherosclerosis, governing lipid accumulation, inflammatory signaling, and plaque stability. Lipin-1 is a multifunctional lipid-metabolic regulator that integrate...

Comprehensive Evaluation of Atherosclerotic Cardiovascular Disease Risk Predictors Across the Pooled Cohort Equations, Predicting Risk of Cardiovascular Disease Events, and an Expanded Model.

BACKGROUND: Ten-year atherosclerotic cardiovascular disease (ASCVD) risk prediction models include the pooled cohort equations (PCE) and the Predicting Risk of Cardiovascular Disease Events (PREVENT) ...

Sex Differences in Outcomes by Revascularization Strategy in Patients With Femoropopliteal Peripheral Arterial Disease: A Substudy of the REVIVE Pooled Analysis.

BACKGROUND: Women have been underrepresented in peripheral artery disease revascularization trials. We aimed to analyze sex-specific outcomes after endovascular therapy (EVT) with stent implantation v...

Wall-Specific V-Flow Hemodynamics in Lower-Limb Peripheral Artery Disease: Diagnostic Nomogram and Periplaque Mapping.

BACKGROUND: Lower limb peripheral artery disease (PAD) involves localized atherosclerosis with disturbed hemodynamics. V-flow imaging is a vector Doppler technique enabling real-time assessment of wal...

Impact of Drug-Coated Balloon Inflation Time on Outcome After Percutaneous Coronary Intervention: An Observational Study From SCAAR.

BACKGROUND: There are limited data guiding the optimal inflation time for coronary drug-coated balloons. The aim of this study was to assess the clinical efficacy of an inflation time of ≥30 seconds c...

Association Between Heart Failure Medications and Outcomes in Patients With Cardiac Sarcoidosis and Left Ventricular Systolic Dysfunction: Insights From ILLUMINATE-CS.

BACKGROUND: Heart failure associated with cardiac sarcoidosis (CS) is typically managed using conventional heart failure medications (HFMs). However, their effectiveness in this specific population re...

Remnant Cholesterol Paradox: Higher Levels Are Associated With Reduced Mortality in Critically Ill Patients With Heart Failure.

BACKGROUND: Remnant cholesterol (RC) is a significant cardiovascular risk factor, but its prognostic value in critically ill patients with heart failure remains inadequately characterized. This study ...

Central Adiposity, Systemic Inflammation, and Incident Heart Failure: A Causal Mediation Analysis From the Jackson Heart Study.

BACKGROUND: Obesity and systemic inflammation have each been independently associated with an increased risk of heart failure (HF). However, whether inflammatory pathways mediate the association betwe...

High-riding brachiocephalic artery presenting as a pulsatile anterior neck mass.

Anterior neck swellings are commonly due to an enlarged thyroid gland, thyroglossal cyst or lymphadenopathy. Vascular causes are unusual and have a prevalence of about 4.5%.Herein, we present the case...

Right Ventricular Metastasis From Cervical Cancer Treated With Pembrolizumab-Containing Chemotherapy: A Case Report and Literature Review.

BACKGROUND Cardiac metastasis from cervical cancer is extremely rare and associated with a poor prognosis. Given its rarity and the critical anatomical location of the lesion, optimal treatment strate...

Beyond the Pump: Unravelling Immunometabolic Crosstalk and Organelle Dynamics in Sepsis-Induced Cardiomyopathy.

Sepsis-induced cardiomyopathy (SICM) has traditionally been viewed as pump-centered contractile failure, but this paradigm fails to explain the clinical spectrum and recovery patterns. This review pre...

Systemic Comorbidities in Central Centrifugal Cicatricial Alopecia: A Systematic Review and Meta-analysis.

Central centrifugal cicatricial alopecia (CCCA) is the most common scarring alopecia among women of African descent and has been increasingly associated with systemic comorbidities, particularly cardi...

Innovative strategies to reduce heart failure hospitalizations: insights from the ESC heart failure congress 2026.

Heart failure (HF) represents a major burden on healthcare systems globally, driven by high rates of hospitalizations and readmissions, as well as prolonged length of stay (LOS). To address this, a wi...

Kaempferol-Conjugated Manganese Oxide Nanocomposites Mitigate Aluminium Chloride-Induced Neurobehavioral Impairments in a Rat Model of Alzheimer's disease.

The neurodegenerative illness Alzheimer's disease (AD) causes cognitive decline. The production of oxidative stress in neurons is thought to play a role in the emergence of AD. The antioxidants, inclu...

Relation of nailfold capillaries and autoantibodies to mortality in patients with Raynaud's phenomenon: a retrospective analysis.

The presence of abnormal nailfold capillaries and antinuclear antibodies (ANA) is associated with increased all-cause mortality in patients presenting with incipient Raynaud's phenomenon (RP). We cond...

Exploring the role of CaMKII in exercise-induced cardioprotection.

Regular physical exercise can induce a multifaceted cardioprotective phenotype characterized by improved Ca2⁺ handling, mitochondrial resilience, redox buffering, autonomic regulation, and resistance ...

The Anatomical Landscape of Living Donor Livers: A 101-Case Retrospective Single-Center Study in Indonesia From 2010 to 2025.

BACKGROUND Anatomical variations of the hepatic vasculature and bile ducts are critical considerations in living donor liver transplantation (LDLT), yet population-specific data remain limited. This r...

Left Ventricular Hypertrabeculation and Prognosis in Dilated Cardiomyopathy.

BACKGROUND: Left ventricular (LV) hypertrabeculation, formerly termed LV noncompaction, is a heterogeneous myocardial entity linked to adverse cardiovascular outcomes. This study evaluated embolic ris...

Nonconjugated Alkyl Chains in Ionic Molecular Rotor Fluorophores: An Effective Modulating Moiety for Amyloid-β Probes.

Developing molecular structural tuning strategies for ionic molecular rotor (MR)-based β-amyloid (Aβ) fluorescent probes is essential for balancing high sensitivity, signal-to-background ratio (SBR) i...