Heart failure with reduced ejection fraction (HFrEF) is characterized by impaired contractility and high mortality. Dysregulation of intracellular ion (ie, Na

Hypertension Incidence and Blood Pressure Control in Hispanic or Latino Adults in the HCHS/SOL Study.

IMPORTANCE: Among US Hispanic or Latino adults, the burden of hypertension is high, with substantial variation by heritage group. The long-term incidence of hypertension and prevalence of blood pressu...

Periprocedural Mortality Risk After Elective Atrial Fibrillation Ablation in Japan.

IMPORTANCE: Evidence on the safety of atrial fibrillation ablation during rapid growth in both procedural volume and the number of hospitals performing it remains inconsistent. Although clinical regis...

Breastfeeding Intensity and Early Postpartum Lipid Profiles Among Women With Prior Gestational Diabetes.

IMPORTANCE: Women with prior gestational diabetes are at high risk of cardiometabolic disease, including dyslipidemia, early in the postpartum period. Identifying modifiable factors associated with li...

Subtype-Specific Macular Microvascular Changes in Accommodative Esotropia Assessed by Optical Coherence Tomography Angiography.

PURPOSE: The purpose of this study was to evaluate macular microvascular alterations in children with accommodative esotropia (AE) using optical coherence tomography angiography (OCTA) and to determin...

Exceptional Parental Longevity and Onset of Morbidity and Mortality Across Cohorts.

IMPORTANCE: Centenarian lifespan extension is frequently accompanied by delayed onset of aging-associated diseases. Understanding the transgenerational patterns of this phenomenon is crucial for infor...

Morphometric Analysis of Retinal Vessels Using High-Resolution OCT Technology in Healthy Subjects.

PURPOSE: To assess the performance of a novel high-resolution optical coherence tomography (High-Res OCT) research platform with 3-µm axial resolution in measuring retinal vascular metrics in healthy ...

Maternal Health Outcomes in Nepalese Women After Mitral Valve Replacement.

BACKGROUND: The effects of anticoagulation on maternal health in patients with prosthetic valves remain understudied. Our study aims to assess maternal health post-mitral valve replacement (MVR), preg...

RE-LOCK and TRACK: A Reproducible Minimally Invasive Repair for Bileaflet Mitral Disease.

Complex bileaflet and Barlow-type degenerative disease remains among the most demanding substrates in reconstructive mitral surgery, and a right mini-thoracotomy amplifies every source of intraoperati...

Mobile Integrated Health and Post-Hospital Discharge Heart Failure Care.

IMPORTANCE: Mobile integrated health (MIH) is a promising model for improving transitions of care for patients with heart failure (HF). National implementation remains limited due to insufficient unde...

Smoking Behavior and Major Cardiovascular and Limb Events in Patients With Peripheral Artery Disease.

IMPORTANCE: Smoking is the strongest modifiable risk factor for peripheral arterial disease (PAD), yet evidence on how postdiagnosis smoking behavior changes affect clinical outcomes remains limited. ...

Psychosocial Stressors and Heart Failure Risk Among Black Women in the US.

IMPORTANCE: Black women are disproportionately susceptible to developing heart failure and display more severe morbidity and mortality compared with White women. Factors contributing to excess heart f...

Restrictive Left Ventricle-to-Pulmonary Artery Conduit as an Alternative Biventricular Strategy in Complex Congenitally Corrected Transposition of the Great Arteries.

OBJECTIVES: Biventricular repair of congenitally corrected transposition of the great arteries (ccTGA) with a nonrestrictive ventricular septal defect (VSD) and left ventricular outflow tract obstruct...

Dynamic and Structural Retinal Microvascular Alterations After Radiation Exposure: Insights From a Large-Animal Model.

PURPOSE: To investigate the effects of acute radiation exposure on retinal microvascular health using the New Zealand White Rabbit (NZWR) model, aiming to enhance understanding of vascular response to...

A Novel SLC25A4 Variant Causing Mitochondrial Dysfunction, Myopathy and Cardiomyopathy: A Functional and Molecular Characterization.

SLC25A4, solute carrier family 25 member 4, gene is a member of the mitochondrial carrier subfamily within the solute carrier protein family. Pathogenic variants in SLC25A4 are associated with a spect...

Matrix Metalloproteinases and Cardiac Remodelling in Smokers with Acute Coronary Syndrome.

Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) regulate extracellular matrix remodeling and contribute to the pathogenesis of coronary artery disease (CAD). This study examined t...

Panoramic Near-Infrared Imaging Device for Peripheral Vascular Mapping.

Longitudinal mapping of the superficial peripheral vascular network is clinically relevant for conditions such as venous insufficiency, superficial venous thrombosis, and localized hemorrhagic injury;...

SDA-SwinNet: Swin-UNet with Dense Skip and Shift-ASPP for Retinal Vessel Segmentation.

Retinal artery/vein segmentation is a prerequisite for many ophthalmic diagnostic tools. Yet, the task remains difficult: vessels form complex trees, vary widely in caliber, and often appear low-contr...

A Heterogeneous Codonopsis pilosula Polysaccharide Preparation Attenuates Doxorubicin-Induced Cardiotoxicity in Mice: Associations with Oxidative Stress, Mitochondrial Function, and Gut Microbiota.

Doxorubicin-induced cardiotoxicity remains a major limitation of anthracycline chemotherapy and is closely associated with oxidative stress and mitochondrial dysfunction. Here, we investigated whether...

Exploring the Role of the LCN2-DHODH Interaction in Mitochondrial Ferroptosis During Sepsis-Induced Myocardial Injury and LPS-Induced HL-1 Cardiomyocyte Injury.

This study aimed to investigate the regulatory effect of lipocalin-2 (LCN2) knockdown on DHODH-mediated mitochondrial ferroptosis in sepsis-induced myocardial injury (SIMI) and clarify the underlying ...