Age- and Sex-Related Patterns in Coronary CT Angiography Referrals and Coronary Atherosclerotic Burden: A Single-Center Real-World Referral-Based Analysis.
Background and Objectives: Coronary computed tomography angiography (CCTA) has become a central non-invasive imaging modality for the evaluation of suspected chronic coronary syndromes. Nevertheless, ...
Congestion-Perfusion Phenotypes and In-Hospital Mortality in Acute Heart Failure: Phenotype-Specific Prognostic Markers and Right-Heart Involvement.
Background and Objectives: Acute heart failure (AHF) has heterogeneous clinical profiles and considerable short-term mortality. Bedside evaluation of congestion and peripheral perfusion may help ident...
Left Atrial Appendage Exclusion via Right Minithoracotomy Using an Epicardial Clip Device During Minimally Invasive Mitral Valve Surgery.
Background and Objectives: Left atrial appendage (LAA) closure is a Class I recommendation in patients with atrial fibrillation to reduce the risk of cardioembolic stroke. Achieving reliable and compl...
TGFβ-Dependent Epithelial-Mesenchymal Plasticity in Immortalized Human Atrial Epicardial Cells: An mRNA Profiling Study.
The adult mammalian heart exhibits limited regenerative capacity. Although the epicardium contributes to cardiac injury responses and remodeling, expandable adult human in vitro models for investigati...
Immunological Reprogramming in Cardiomyopathies: From Cardiomyocyte Injury to Disease of the Cardiac Immune Ecosystem.
Cardiomyopathies have traditionally been regarded as disorders driven primarily by cardiomyocyte injury resulting from genetic defects, infection, metabolic stress, or toxic exposure. This paradigm ha...
Feasibility of a noninvasive photoplethysmography-based wearable chest patch for cardiac output assessment during exercise compared with thermodilution right heart catheterization.
Hemodynamic monitoring with cardiac output (CO) assessment is usually based on invasive methods that are associated with potential complications. This study compared CO measurements during exercise ob...
Hypercholesterolemia induced by hypothyroidism is ameliorated by taurine supplementation through the hepatic AMPK/ACC pathway.
OBJECTIVE: To evaluate the effect of taurine supplementation on the lipid profile of male hypothyroid Wistar rats. MATERIALS AND METHODS: Adult male Wistar rats were induced to hypothyroidism by treat...
The Future of Imaging in Heart Failure: Toward Precision Phenotyping, Integration, and Intelligence.
PURPOSE OF REVIEW: Heart failure (HF) is increasingly understood not as a single, uniformly treated diagnosis but as a heterogeneous syndrome requiring aetiological clarification, in which cardiac ima...
The Clearance-Centered Bottleneck in Alzheimer's Disease: From Coupled Glymphatic-Lymphatic Circuits to Therapeutic Opportunities.
While anti-amyloid-beta (Aβ) monoclonal antibodies have achieved substantial success in reducing plaque burden, their modest clinical impact highlights an "efficacy ceiling" that necessitates a re-eva...
Loss of Vascular TMEM16A Impairs Cerebral Autoregulation and Exacerbates Ischemia-reperfusion Injury.
TMEM16A forms a Ca²⁺-activated Cl⁻ channel in vascular mural cells (smooth muscle cells and pericytes) that generates depolarizing Cl⁻ efflux upon intracellular Ca²⁺ elevation, thereby amplifying agon...
Computational modeling of tissue damage preceding aortic dissection: a coupled biphasic and reactive viscoelastic framework.
Aortic dissection is a life-threatening pathology characterized by the progressive delamination of adjacent lamellar units within the aortic media. Because this internal damage propagates predominantl...
Serial failure of the brain clearance continuum in Alzheimer's disease: mechanisms and therapeutic perspectives.
Alzheimer's disease (AD) is usually regarded as a neurodegenerative disorder defined by amyloid-β (Aβ) deposition and abnormal tau accumulation. Increasing evidence suggests that reduced clearance of ...
A loss-of-function polymorphism in the propeptide of lysyl oxidase exacerbates atherosclerosis.
A single-nucleotide missense polymorphism (rs1800449, R158Q) in the propeptide domain of lysyl oxidase (LOX-PP) is associated with increased risk of coronary artery disease (CAD) independent of change...
Arterial stiffness parameters during six-month antihypertensive therapy: a prospective observational study.
AIM: To investigate the prevalence of arterial stiffness in hypertensive patients in Bosnia and Herzegovina and to assess the effects of various antihypertensive therapies on arterial stiffness. METHO...
Strategy-based revascularization for complex femoropopliteal disease: endovascular-first versus surgical bypass in contemporary practice.
AIM: To compare the outcomes of endovascular treatment (EVT) and surgical bypass (BP) for the management of complex femoropopliteal (FP) artery disease. METHODS: This retrospective single-centre cohor...
Association of Thyroid Dysfunction With Dyslipidemia and Metabolic Risk in the Health Examination Population: A Retrospective Analysis.
This study aims to investigate the associative relationships between thyroid dysfunction, dyslipidemia, and other metabolic risks among people undergoing health examinations. 305 individuals undergoin...
Dl-3-n-Butylphthalide Protects Human Brain Microvascular Endothelial Cells Against Ischemic Injury Through Dual Modulation of HIF1α/VEGF-Mediated Angiogenesis and COX2-Mediated Inflammation.
BACKGROUND: Stroke remains a leading cause of death and disability worldwide. Endothelial dysfunction plays a central role in both acute ischemic injury and subsequent recovery. In this study, we inve...
Chronic Kidney Disease-Associated Cardiomyopathy: Mechanisms and Therapeutic Strategies.
Chronic kidney disease-associated cardiomyopathy (CKD-CM) is a term that captures the spectrum of myocardial disease that begins early in chronic kidney disease (CKD) and progresses as kidney function...
Resveratrol Ameliorated Hyperlipidemia: Association with Modulation of the Gut Microbiota and Bile Acid Metabolism.
Background: Hyperlipidemia represents a pivotal risk factor for multiple cardiovascular and metabolic diseases, creating an urgent demand for safe, effective novel therapeutic interventions. Resveratr...
Genetic Determinants of Autoimmune Myocarditis: From Candidate Genes to GWAS Insights.
Autoimmune myocarditis is an inflammatory disease of the myocardium driven by immune dysregulation and genetic predisposition. Recent advances in genomics, including genome-wide association studies (G...