Integrated Bioinformatics and Machine Learning Analysis Identifies Inflammation-Related Biomarkers and Immune Infiltration Patterns in Atherosclerosis.
Background: Atherosclerosis (AS) is a chronic inflammatory vascular disease lacking reliable biomarkers for early diagnosis and risk stratification. This study aimed to identify hub genes with diagnos...
Exercise-Induced Plasma Surfactant Protein B Response in Advanced Heart Failure: Relation to Exercise Limitation, Resting Invasive Hemodynamics, and Clinical Outcomes.
Plasma surfactant protein B (SPB) is a marker of alveolar-capillary barrier injury and is elevated in heart failure (HF). We assessed whether cardiopulmonary exercise testing (CPET) changes plasma SPB...
Effects of Antiarrhythmics on Cardiac Phenotype and Redox Balance in Spontaneously Hypertensive Rats.
Arterial hypertension is a well-known risk factor for cardiac arrhythmias, while certain antihypertensive agents may also create conditions for arrhythmia occurrence. The aim of this study was to eval...
Alcohol Metabolism into Acetaldehyde in Developing Cerebral Arteries.
Alcohol exposure during pregnancy leads to fetal alcohol spectrum disorders (FASD), yet the mechanisms through which alcohol disrupts the developing cerebrovasculature remain poorly defined. Acetaldeh...
Valve-Related Outcomes up to Six Years of a Next-Generation Bovine Pericardial Bioprosthesis Compared with Its Predecessor: A Propensity-Matched Analysis.
Background: Current ESC/EACTS guidelines recommend bioprosthetic valves for aortic valve replacement (AVR) in patients > 65 years, yet their use is increasing among younger individuals. The INSPIRIS R...
Comprehensive biophysical and structural profiling of alpha-actinin-2 variants reveals mechanistic diversity in hypertrophic cardiomyopathy.
Hypertrophic cardiomyopathy (HCM) is a genetic disease associated with sudden cardiac death. Variants in alpha-actinin-2 (ACTN2), a Z-disc protein that anchors actin thin filaments have been implicate...
Beyond epilepsy: convulsive syncope revealing restrictive cardiomyopathy in a child.
Seizure-like episodes may occasionally arise from cardiovascular causes rather than primary neurological disease, leading to diagnostic delay. We report an adolescent girl who presented with recurrent...
Effects of Remote, Virtual, or Hybrid Cardiac Rehabilitation Supported by mHealth in Patients With Heart Failure: Systematic Review and Meta-Analysis.
BACKGROUND: Structured exercise is a key component of cardiac rehabilitation (CR) for patients with heart failure (HF), but access to center-based cardiac rehabilitation (CBCR) is often limited. Mobil...
Proteomic Profiling of RHD-Related Mitral Annulus Calcification Enabled by Magnetic Carbon Nanomaterial-Supported Quasi-Immobilized Enzyme Digestion.
Elucidating the mechanisms underlying rheumatic heart disease (RHD) accompanied by mitral annulus calcification (MAC) facilitates the identification of sensitive diagnostic biomarkers and the developm...
Influence of wall distensibility on local hemodynamics at the normal carotid bifurcation: a fluid-structure interaction study.
The role of local hemodynamics on atherosclerosis at the carotid bifurcation has been the subject of study by computational fluid-dynamics (CFD) simulations for over three decades. Nevertheless, quest...
Intracranial Mitochondrial Microparticles Promote Cerebral Edema via Endothelial Injury in Stroke.
Vascular endothelial injury underlies the development of severe complications following acute ischemic stroke. While mitochondrial microparticles (mtMPs) compromise endothelial integrity, their mechan...
A hybrid phenomenological finite element model of transcatheter aortic valve leaflet behaviour under non-circular annular deployment: in vitro validation and biomechanical insights.
Transcatheter aortic valves (TAVs) typically operate on non-circular rings, but the impact of annular ellipticity on valve mechanics remains insufficiently quantified. In this study, we present a fini...
Haemodynamic and biomechanical biomarker analysis of carotid fibromuscular dysplasia via fluid-structure interaction.
This study aims to investigate the biomechanical behaviour of the carotid artery in patients with fibromuscular dysplasia (FMD) disease. Carotid FMD is an arterial disease lacking either inflammatory ...
Quantitative computerized analysis demonstrates strongly compartmentalized tissue deformation patterns underlying mammalian heart tube formation.
The quantitative analysis of tissue deformation at cellular resolution remains an important challenge in mammalian organogenesis. Here, we developed a new computational workflow to extract regional an...
Protein corona guided albumin-binding paclitaxel nanoparticles for treatment of intracranial tumors.
Albumin-bound paclitaxel (Abraxane) exhibits potent antitumor activity, but its suboptimal pharmacokinetics and the restrictive blood-brain barrier (BBB) greatly limit the broader application of album...
Middle meningeal artery arteriovenous shunting after surgical evacuation of chronic subdural hematoma: a retrospective angiographic cohort study.
Arteriovenous shunting involving the middle meningeal artery (MMA) has been reported after cranial trauma, neurosurgical procedures, and endovascular interventions. However, its angiographic frequency...
Diagnostic Approach to Cardiac Sarcoidosis.
Cardiac sarcoidosis is a granulomatous myocarditis, classified by some authorities as an infiltrative cardiomyopathy and by others as an inflammatory cardiomyopathy, that carries an elevated risk of l...
Does Characterization of Phenotypic Heterogeneity Provide Mechanistic Insights or Influence the Response to Treatment? Experience in Positive and Neutral Trials in Patients With Heart Failure and a Preserved Ejection Fraction.
At a time when there was no unifying hypothesis and no broadly effective treatments for heart failure with a preserved ejection fraction (HFpEF), it was proposed that HFpEF represented a multitude of ...
Loss of ATP-Dependent Citrate Lyase Drives Left Ventricular Dysfunction by Metabolic Remodeling.
BACKGROUND: Metabolic adaptation and maladaptation are hallmarks of the failing heart and may be a target for therapeutic interventions. For example, sustained glucose oxidation during cardiac stress ...
ROS produced in mitochondria entrapped by self-assembly peptide fibers for target therapy of glioma.
Brain glioma is a highly energy-dependent malignant tumor. Sonodynamic therapy (SDT) provides a noninvasive and effective approach for brain glioma therapy. Reactive oxygen species (ROS) from sonosens...