Targeting LDL Across the Whole Spectrum of Chronic Kidney Disease: From Pathophysiology to Novel Treatments.
PURPOSE OF REVIEW: The natural fate of chronic kidney disease (CKD) is the progression to dialysis; however, most patients face fatal and nonfatal cardiovascular events throughout their lifetime. We h...
Within-sibling attenuation of polygenic risk score accuracy: investigating the effects of principal component analysis, LD score regression, and mixed model association in the UK Biobank.
A central challenge in polygenic risk prediction is measuring and controlling for confounding due to population stratification. Standard approaches include adjusting for leading principal components (...
Heart failure promotes gingival inflammation and impairs periodontal remodeling.
Observational studies suggest an association between impaired oral health and cardiovascular disease; however, the directionality and underlying mechanisms remain unclear. In particular, whether heart...
Myocarditis as the first sign of SLE: a case report and review of the literature.
Lupus myocarditis (LM) is a rare but potentially life threatening manifestation of systemic lupus erythematous (SLE). LM may be rarely the initial presentation of SLE or ma y be presented during the c...
Assessment of aortic insufficiency during Impella support as a bridge to durable left ventricular assist device implantation and its long-term progression.
Impella is increasingly used as a bridge to durable left ventricular assist device (dLVAD) implantation in patients with advanced heart failure. However, Impella support may worsen aortic insufficienc...
Stem cell-based regenerative therapies for non-ischemic cardiomyopathy: mechanistic insights, clinical evidence, and future directions.
Non-ischemic cardiomyopathy (NICM) includes a wide spectrum of myocardial disorders that result in ventricular dysfunction in the absence of significant coronary artery disease. The currently availabl...
Case report: exercise-associated sudden death in a Thoroughbred racehorse with cardiac lesions.
Exercise-associated sudden death (EASD), defined as acute collapse and death in an apparently healthy racehorse during or within ~1 h after exercise, is currently among the top concerns in the racing ...
Non-transferrin-bound iron uptake by cardiomyocytes.
Under conditions of iron overload, increased non-transferrin-bound iron (NTBI) can gain access to cardiomyocytes, cause cardiac iron accumulation and generate reactive oxygen species which can result ...
Diagnostic Tests for Stage B Heart Failure.
PURPOSE OF THE REVIEW: To provide an overview of diagnostic tests for Stage B heart failure (SBHF), synthesizing evidence from guidelines and clinical studies. RECENT FINDINGS: Advances in diagnostic ...
Focused ultrasound-mediated blood-brain barrier opening to enhance temozolomide delivery in glioblastoma: a systematic review of preclinical and early clinical evidence.
Glioblastoma (GBM) is the most aggressive primary malignant brain tumor in adults, with persistently poor survival despite chemoradiation and temozolomide (TMZ). Limited intratumoral drug delivery imp...
The fate of the contralateral limb after major lower limb amputation for peripheral arterial disease or diabetes mellitus.
BACKGROUND: The contralateral limb is at risk after major lower limb amputation (MLLA) for peripheral arterial disease or diabetes mellitus due to the systemic nature of these diseases, with a subsequ...
Socioeconomic, ethnic and geographical disparities in revascularization rates for peripheral arterial disease in England.
BACKGROUND: There are disparities in the prevalence of peripheral arterial disease (PAD). This study examined socioeconomic, ethnic, and geographical variations in population-based revascularization r...
Clinical Practice Guideline on the Pharmacological Management of Antipsychotic-Related Dyslipidemia.
BACKGROUND: People taking antipsychotic medicines and those with severe mental illness experience elevated cardiovascular risk compared to the general population which is not adequately addressed by e...
Acute intravenous antihypertensive and in vitro vasorelaxant effect of the hydroalcoholic stem bark extract of Hymenaea rubriflora Ducke in spontaneously hypertensive rats.
OBJECTIVES: The cardioprotective potential of Hymenaea rubriflora Ducke's stem bark hydroalcoholic extract (HR-HAc) has not yet been investigated. This study aimed to quantify HR-HAc's antioxidant cap...
Prevalence and Perioperative Implications of Cardiovascular Comorbidities in Non-Cardiac Surgery: A Three-Year Retrospective Cohort Study.
Background and Objectives: Cardiovascular diseases (CVDs) are the leading cause of global morbidity and mortality, and significantly influence perioperative risk in non-cardiac surgery. This study aim...
Shanhuang Jiangzhi tablets mitigate atherosclerosis by modulating macrophage polarization and inhibiting foam cell formation via the ROS/TLR4/NF-κB pathway.
OBJECTIVES: Atherosclerosis significantly contributes to global cardiovascular mortality. Macrophage polarization and foam cell formation via oxidized low-density lipoprotein uptake are key drivers of...
Nanocarrier-based targeting strategies in epilepsy: addressing pathophysiological barriers.
OBJECTIVES: Epilepsy is a chronic neurological disorder affecting nearly 50 million people worldwide and is characterized by recurrent seizures caused by abnormal neuronal activity. Conventional thera...
Comparative evaluation of left atrial appendage occlusion and oral anticoagulation: a Bayesian meta-analysis of randomized controlled trials.
AIMS: Randomized trials comparing percutaneous left atrial appendage occlusion (LAAO) with oral anticoagulation (OAC) for stroke prevention in patients with atrial fibrillation have yielded conflictin...
Long-term efficacy and safety of left atrial appendage closure vs. oral anticoagulation in atrial fibrillation: a meta-analysis of randomized controlled trials.
AIMS: Left atrial appendage closure (LAAC) has emerged as an alternative to oral anticoagulation (OAC) for stroke prevention in atrial fibrillation (AF), but its long-term comparative efficacy remains...
Histological evaluation of clinically defined atrial cardiomyopathy stages and their association with atrial fibrillation burden under continuous monitoring for a 2.5-year follow-up.
BACKGROUND AND AIMS: Atrial cardiomyopathy (AtCM) is associated with atrial fibrillation (AF). While histological studies describe underlying mechanisms of AtCM, these insights remain disconnected fro...