Heart failure with preserved ejection fraction (HFpEF) is a poorly understood, multisystem disease with high morbidity and mortality. To improve understanding of its pathobiology, we analyzed single-n...
Heart failure with preserved ejection fraction (HFpEF) is a poorly understood, multisystem disease with high morbidity and mortality. To improve understanding of its pathobiology, we analyzed single-n...
Although pulmonary arterial hypertension (PAH) is a rare and fatal disease that is well-characterized, vasodilator-responsive PAH accounts for a minority of cases, with little mechanistic knowledge, b...
Heart failure remains a major global health burden, driven largely by pathological cardiac hypertrophy. Mitochondrial dysfunction, particularly impaired mitochondrial complex I activity, is central to...
Atherothrombosis, which underlies most acute coronary syndromes and is driven by intraplaque thrombosis, preferentially occurs in regions of disturbed blood flow (d-flow). Although LATS1/2 (large tumo...
The Role of Multimodality Imaging in Atrial Fibrillation and Heart Failure: From Patient Selection to Procedural Ablation Guidance.
Atrial fibrillation (AF) and heart failure (HF) frequently coexist and mutually worsen prognosis, creating a complex clinical scenario in which treatment decisions are increasingly imaging driven. Cat...
Incremental Value of Iodine-125 Seed Implantation After Bronchial Artery Chemoembolization in Immunotherapy-Treated Advanced Lung Squamous Cell Carcinoma with Hemoptysis: A Retrospective Cohort Study Using Inverse Probability of Treatment Weighting.
BACKGROUND: The incremental value of iodine-125 (I-125) seed implantation in advanced refractory lung squamous cell carcinoma (LUSC) with hemoptysis treated with bronchial artery chemoembolization (BA...
Associations of Serum 25-Hydroxyvitamin D Concentrations and Lipid Profiles Across Adiposity Status Among Children and Adolescents Aged 9-17 Years: A Cross-Sectional Study in Guangzhou, China.
Background: Childhood dyslipidemia often tracks into adulthood and contributes to early atherosclerotic changes. Although serum 25-Hydroxyvitamin D (25(OH)D) has been implicated in lipid metabolism, f...
Special Issue: Recent Research on Hypertension and Related Complications.
Hypertension is still the most important risk factor in which alterations can control heart and kidney diseases, stroke, and early deaths worldwide [...].
The Role of Hydrogen Bond Donors and Intramolecular Hydrogen Bonding in Modulating Blood-Brain Barrier Permeability: Implications for CNS Drug Design.
The blood-brain barrier (BBB) represents a major challenge in central nervous system (CNS) drug development due to its selective permeability. Multiple molecular properties such as lipophilicity, mole...
Vascular reprogramming in cancer: engineering the tumor microenvironment.
Tumor vasculature has traditionally been viewed as structurally and functionally abnormal and, therefore, is primarily targeted for inhibition. However, emerging evidence from vascular biology, regene...
Secular trends in society-, school-, and individual-level factors related to physical activity and their associations with elevated blood pressure among 0.6 million children and adolescents.
BACKGROUND: Physical activity (PA) is a key modifiable factor for elevated blood pressure (EBP). We aimed to clarify the evolving relationships between PA and EBP in childhood or adolescence by examin...
Surgical Septal Myectomy and Atrial Myxoma Resection: Two Diseases, One Heart, and a Case Report.
BACKGROUND The coexistence of cardiac myxoma and hypertrophic cardiomyopathy is exceedingly rare and poses diagnostic and therapeutic challenges. While atrial myxomas may cause acute hemodynamic compr...
Device therapies in cardiorenal syndrome: an expert review.
Managing cardiorenal syndrome in acute decompensated heart failure remains a major challenge in contemporary cardiology. While pharmacological decongestion with diuretics is the cornerstone of therapy...
Left atrial remodelling and diastolic unloading after transcatheter tricuspid repair.
BACKGROUND AND AIMS: Severe tricuspid regurgitation (TR) alters ventricular interaction and left-sided filling dynamics. However, the longitudinal effects of transcatheter tricuspid edge-to-edge repai...
The AS-PAD Score Predicts Significant Peripheral Artery Disease and Is Associated with Femoral Access-Site Closure Device Failure in Patients Undergoing TAVI.
Background and Objectives: Patients with severe aortic stenosis (AS) frequently present with concomitant peripheral artery disease (PAD), which complicates transcatheter aortic valve implantation (TAV...
Severe tricuspid regurgitation: aetiology, patient characteristics, and treatment: a multicentre, prospective registry.
BACKGROUND AND AIMS: Severe tricuspid regurgitation (TR) is associated with increased mortality and hospitalizations for heart failure (HF). Aetiologies of TR include: secondary (atrial or ventricular...
Endovascular Intervention and the Vascular Glycocalyx in Patients with Chronic Limb-Threatening Ischaemia: A Prospective Observational Study.
This single-center prospective observational study evaluated peri-procedural changes in circulating markers of endothelial glycocalyx injury in patients with chronic limb-threatening ischemia undergoi...
The HFpEF-ABA score predicts adverse cardiac remodelling and incident heart failure: a UK biobank study.
INTRODUCTION: The HFpEF-ABA score (age, body mass index, atrial fibrillation) was originally derived to diagnose heart failure with preserved ejection fraction (HFpEF) in symptomatic patients. However...
The Spectrum of Genetic Causes of Familial Hypercholesterolemia Phenotype.
PURPOSE OF REVIEW: This paper reviews the genetic spectrum underlying the Familial Hypercholesterolemia (FH) phenotype, aiming to improve diagnosis, awareness and understanding of these inherited lipi...
Mavacamten in adolescent obstructive hypertrophic cardiomyopathy: SCOUTing a way forward.
Paediatric obstructive hypertrophic cardiomyopathy (oHCM) is a rare inherited cardiac disease that may present from childhood through adolescence and is associated with substantial long-term morbidity...