Atrial fibrillation burden during in-patient cardiac monitoring after acute ischaemic stroke.
BACKGROUND: Atrial fibrillation (AF) burden, the time spent in AF, is increasingly investigated. Data on its characteristics and temporal patterns during early in-hospital telemetry after ischaemic st...
Imaging and Molecular Biomarkers of PFAS-Related Vascular Aging: A Narrative Review.
Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants increasingly associated with cardiovascular disease. Identifying early manifestations of vascular aging before the ...
Neuroinvasive Free-Living Amoebae Pathogenesis, Neuroinflammation and Therapeutic Challenges.
Neuroinvasive free-living amoebae (FLA), particularly Naegleria fowleri and Acanthamoeba spp., are responsible for rare but devastating infections of the central nervous system (CNS). Approximately 48...
Contemporary achievement of guideline recommendations for blood pressure management after stroke in the CONVINCE trial.
INTRODUCTION: Hypertension is a major modifiable risk factor for stroke. Studies between 1996 and 2013 reported high rates of non-achievement of guideline recommended blood pressure (BP) targets follo...
Preliminary Report of a Nationwide Prospective Cohort of Congenital Diaphragmatic Hernia in Korea.
BACKGROUND: Most congenital diaphragmatic hernia (CDH) cases are identified prenatally, enabling early multidisciplinary interventions, including maternal transfer and preparation for extracorporeal m...
Predicting Mortality After Percutaneous Coronary Intervention in a Multiethnic Southeast Asian Population: Insights From Machine Learning.
Ischemic heart disease remains a major contributor to mortality in Malaysia, with non-elective percutaneous coronary intervention (PCI) frequently performed in high-risk acute coronary syndrome (ACS) ...
VIR-SAAF: a study protocol for a national decentralised randomised controlled trial of home-based sleep apnoea screening in patients with atrial fibrillation in Denmark.
BACKGROUND: Obstructive sleep apnoea (OSA) is a common and modifiable risk factor for atrial fibrillation (AF), yet it remains frequently unrecognised and undertreated. Despite guideline recommendatio...
Circadian regulation of cardiovascular function: from physiology to clinical implications.
Circadian rhythms play a crucial role in maintaining cardiovascular homeostasis, orchestrating fluctuations in blood pressure, heart rate variability, endothelial function, and systemic vascular tone....
Voluntary wheel running reduces infarct size through thioredoxin-1 and survival pathways.
Ischemic heart disease remains the leading cause of mortality worldwide, and exercise is recognized as one of the most effective non-pharmacological strategies for cardioprotection. Voluntary wheel ru...
Patients' Experiences of Nurse-Led eHealth Interventions for Chronic Heart Failure: Qualitative Systematic Review and Meta-Synthesis.
BACKGROUND: Chronic heart failure (CHF) is a major chronic condition in the context of global population aging and is associated with high prevalence, frequent rehospitalization, and high mortality. S...
A novel pathogenic synonymous DHCR7 variant unveiled by aberrant splicing in Smith-Lemli-Opitz syndrome.
Synonymous mutations, once regarded as silent, are increasingly recognized as pathogenic through disruption of mRNA splicing. Here, we report a prenatal case with classic features of Smith-Lemli-Opitz...
A platelet-monocyte pyroptotic axis mediates uremic cardiomyopathy: critical role of PF4 and hematopoietic caspase-1.
BACKGROUND: Cardiovascular disease is the leading cause of death in end-stage renal disease (ESRD). While platelet activation and monocyte inflammation are hallmarks of uremia, how platelet-derived fa...
Effect of the interaction between noise exposure and AGT gene polymorphisms in steelworkers on essential hypertension.
PURPOSE: Although steelworkers are exposed to occupational noise, few studies have investigated the interaction between noise and genetic polymorphisms in relation to essential hypertension (EH). This...
Segmental vertebral artery agenesis with deep cervical reconstitution in a cervicothoracic variant cluster.
PURPOSE: To report a complex cervicothoracic vascular-osseous phenotype detected on CTA and define its surgical and radiological relevance. METHODS: Neck CTA of a 76-year-old woman was reviewed on mul...
Prosthesis-patient mismatch with intra-annular self-expanding valves: an analysis of the PORTICO IDE trial.
BACKGROUND: Aortic valve replacement in small aortic annuli is associated with an increased risk of impaired haemodynamics. AIMS: We sought to evaluate haemodynamic outcomes and prosthesis-patient mis...
Left atrial appendage closure with the AnchorMan or Watchman devices: 12-month results of the SAFE-PROTECT randomised trial.
BACKGROUND: Percutaneous closure of the left atrial appendage (LAA) is an alternative to chronic oral anticoagulation to reduce stroke risk in patients with non-valvular atrial fibrillation (AF). AIMS...
Elevated interleukin-36γ and gene polymorphisms implicate novel risk in essential hypertension.
Cytokines are crucial in regulating hypertension and vascular inflammation. The clinical significance of circulating IL-36γ levels and IL36G gene variants in relation to essential hypertension risk wa...
Identifying risk individuals for heart failure diagnosis within two years in the adult population in southern Sweden using gender, age, multimorbidity level, and socioeconomic status.
BACKGROUND: Heart failure (HF) is a common disease among older individuals and is associated with poor quality of life and prognosis. Individuals at risk of developing HF are usually already patients ...
Association of anti-catecholaminergic antiarrhythmic drugs with survival in sepsis-associated new-onset atrial fibrillation.
Sepsis-induced new-onset atrial fibrillation (NOAF) is a potentially life-threatening arrhythmogenic complication, partially driven by catecholamine-mediated atrial remodeling. While β-adrenergic rece...
Computer modeling to improve measurement of stroke volume with echocardiography.
BACKGROUND: The stroke volume (SV) can be measured by a human expert (HE) using the left ventricular outflow tract diameter (LVOTd) and its velocity time integral (VTI) with echo. If the SV is known, ...