[Compound Ciwujia Granules for chronic fatigue syndrome with syndrome of deficiency of both heart and spleen: a multicenter, randomized, double-blind, double-dummy, positive drug-controlled trial].

This study aimed to evaluate the clinical efficacy and safety of Compound Ciwujia Granules in patients with chronic fatigue syndrome with syndrome of deficiency of both heart and spleen. It adopted a ...

[Study on mechanism of Zhenwu Decoction against heart-kidney Yang deficiency-induced heart failure via cAMP/PKA signaling pathway].

This study aimed to investigate the effects of Zhenwu Decoction(ZWT) on cardiac fibrosis in mice with heart-kidney Yang deficiency-induced chronic heart failure(CHF). The research further explored the...

[Roles of vascular smooth muscle cells phenotype transformation in mediating progression of diabetic macroangiopathy and current status of traditional Chinese medicine treatment].

Diabetic macroangiopathy, a major chronic complication of diabetes, is characterized by atherosclerosis. Its pathological core involves the phenotype transformation of vascular smooth muscle cells(VSM...

[Costunolide improves sorafenib-induced cardiomyocyte injury by inhibiting mitophagy].

This study focused on the protective effect of costunolide(COS) against sorafenib(SOR)-induced cardiomyocyte injury and its association with mitophagy. Cell viability was assessed using the CCK-8 assa...

Analysis of the diabetic arterial transcriptome to define novel biomarkers of macrovascular disease.

Diabetes mellitus (DM) approximately doubles the risk of atherosclerotic cardiovascular disease (ASCVD) events, but the molecular basis is poorly understood. Using RNA-sequencing data from two arteria...

Homocysteine-induced endothelial dysfunction through mediating endoplasmic reticulum stress.

ObjectiveEndothelial dysfunction is a key pathological process in cardiovascular and cerebrovascular diseases. Herein, we aimed to investigate the effect of homocysteine on endoplasmic reticulum stres...

Treatment of Portal Biliopathy-Related Bile Duct Stricture Using a Two-Step Approach: Proximal Splenorenal Shunt and Roux-en-Y Hepaticojejunostomy.

Portal biliopathy, also referred to as portal cavernoma cholangiopathy, is a biliary complication of extrahepatic portal vein obstruction caused by cavernomatous transformation of the portal vein and ...

Synchronized left anterior/posterior fasciculars pacing - a modified strategy for difficult left ventricular lead implantation during CRT-D: A case report.

Cardiac resynchronization therapy - defibrillator (CRT-D) is an effective treatment for ischemic heart failure (HF). But, it is a tricky challenge for left ventricular lead implantation difficulties d...

Remote Patient Monitoring Adoption for Hypertension Management Among Medicare Beneficiaries.

IMPORTANCE: Remote patient monitoring (RPM), including self-measured blood pressure monitoring with clinician review and telehealth-supported feedback, can support hypertension management. However, RP...

Global and Domain-Specific Cognitive Outcomes After Catheter Ablation for Atrial Fibrillation.

IMPORTANCE: Atrial fibrillation (AF) is associated with cognitive impairment, but the cognitive effects of catheter ablation (CA) using contemporary techniques remain uncertain. OBJECTIVE: To evaluate...

Let-7e-5p promotes cardiac hypertrophy by targeting LBH and regulating the IGF-PI3K-AKT signaling pathway.

BACKGROUND: Cardiac hypertrophy refers to the compensatory response of the heart to various physiological or pathological stimuli in order to maintain its function. Let-7e-5p has been reported to be u...

A novel nutritional index for hypertension risk and prediction: Cross-sectional, prospective, and trajectory evidence from the English Longitudinal Study of Ageing.

ObjectiveHypertension is a common and modifiable cardiovascular risk factor. The triglyceride-total cholesterol-body weight index is a novel metabolic indicator derived from routine clinical measureme...

Sepsis-Related Coronary Endarteritis With Multiple Coronary Artery Thrombi and Acute Myocardial Infarction.

Histological examination revealed acute myocardial infarction in the anterior wall and ventricular septum, with in-stent occlusive thrombosis overlying neoatherosclerosis in the left anterior descendi...

Monocyte-to-HDL-cholesterol ratio and 1-year mortality in critically ill coronary heart disease: A MIMIC cohort study.

ObjectiveThe monocyte-to-high-density lipoprotein cholesterol ratio (MHR) integrates inflammatory burden with anti-inflammatory lipid status, yet its prognostic value for long-term outcomes in critica...

Does Venous Drainage Route Matter? Portal Versus Systemic Drainage in Isolated Intestinal Transplantation: An Analysis of the National UNOS Database.

BACKGROUND: Type of venous drainage in isolated intestinal transplantation (ITx) may influence immune responses through hepatic filtration of gut-derived antigens and affect outcomes. METHODS: We anal...

Nanomedicine for Glioblastoma Therapy: Novel Insights and Future Perspectives.

Glioblastoma (GBM) remains one of the most aggressive primary brain tumors, with poor prognosis, high recurrence, and limited therapeutic options. Although substantial progress has been made in drug d...

Left Atrial Reservoir Strain Combined With Left Ventricular Longitudinal Strain Improves Discrimination of HFpEF in Patients With Hypertension.

Early identification of heart failure with preserved ejection fraction (HFpEF) in hypertensive patients remains challenging using conventional parameters alone. This retrospective study aimed to asses...

Cardiovascular Risk Factor Prevalence and Control by Education Strata in Older Adults in 3 Countries.

IMPORTANCE: Improvements in cardiovascular disease (CVD) mortality have plateaued in the US and have increased among adults with fewer years of education, a pattern not seen in peer countries. Differe...

Acute Coronary Syndrome Linked to Massive Coronary Artery Aneurysms as Late Complications of Kawasaki Disease: A Case Report.

Kawasaki disease (KD) is an acute childhood vasculitis that may cause late coronary complications. We report a 25-year-old man with childhood KD who presented with acute coronary syndrome without conv...

Restrictive vs Liberal Transfusion Strategy After Myocardial Infarction: A Post Hoc Analysis of the MINT Randomized Clinical Trial.

IMPORTANCE: The decision to transfuse a patient with myocardial infarction (MI) and anemia at a higher vs lower hemoglobin threshold must consider the potential benefit of reduced risk of 30-day death...