Singapore Advanced Cardiac Life Support Guidelines 2026.
Advanced cardiovascular life support (ACLS) provides a structured approach to the management of cardiac arrest and life-threatening arrhythmias, building on early recognition, high-quality cardiopulmo...
Case analysis of tachycardia-induced cardiomyopathy secondary to persistent tachycardia in children.
Tachycardia-induced cardiomyopathy secondary to persistent tachycardia in children is a distinct form of cardiomyopathy caused by sustained or frequent tachyarrhythmias. It is characterized by cardiac...
Cell-Type-Specific Regulation of Ferroptosis in Atherosclerosis: Mechanisms and Therapeutic Potential of Natural Products.
Ferroptosis is a regulated form of cell death in which disturbed iron metabolism, accumulation of peroxidized membrane lipids, and insufficient glutathione peroxidase 4 (GPX4) activity converge to inj...
Chronic Aspartame Exposure Leading to Hypertension in Mice may be Related to the Activation of the Wnt/β-Catenin Signaling Pathway in the Hypothalamus.
Aspartame is a commonly used sweetener that is increasingly becoming the main source of sweetness in foods due to its low-calorie and high-sweetness characteristics. Excessive intake of aspartame can ...
Evaluation of the effect of mavacamten on left ventricular function in obstructive hypertrophic cardiomyopathy using myocardial work.
OBJECTIVE: To evaluate the effect of 12-week Mavacamten on left ventricular function in obstructive hypertrophic cardiomyopathy (oHCM) using myocardial work analysis, and explore its role in myocardia...
Epicardial Lead Dysfunction in a Patient With Mechanical Tricuspid Valve-A Challenging Complication.
Complete atrioventricular block after mechanical tricuspid valve replacement represents a challenging pacing scenario because transvalvular right ventricular lead placement is contraindicated. We repo...
Serum Uric Acid Changes in Relation to Nighttime Blood Pressure Dipping Status in Patients on Antihypertensive Therapy.
We performed a post hoc exploratory secondary analysis to investigate whether baseline circadian blood pressure (BP) pattern was associated with changes in serum uric acid (SUA) during 8-week antihype...
Adverse Oral Mucosal Reaction to Sublingual Captopril: A Case Report With Exploratory Insights Into AI-Assisted Clinical Reasoning.
AIMS: To describe a probable oral mucosal injury associated with the off-label sublingual administration of captopril in a medically complex patient, and to illustrate the role of structured clinical ...
Capillary endothelial cell heterogeneity in skeletal muscle of female and male mice.
In skeletal muscle, capillaries have been shown to be critical to active hyperemia by sensing skeletal muscle activity and directing blood flow to contracting muscle fibers. There is evidence to sugge...
Early Functional Recovery and Myocardial Deformation Improvement After Transcatheter VSD Closure: A 3D Speckle-Tracking Echocardiography Study.
BACKGROUND: Transcatheter closure of ventricular septal defects (VSDs) has become a widely accepted alternative to surgical repair, owing to its high success rates and lower risk of complications. Adv...
CT-Based Reference Ranges for Canine Pyloric Thickness: Influence of Body Size and Normalization With Aortic Diameter.
Pyloric wall thickness reflects pyloric pathology. Prior related studies included small samples and did not consistently measure perpendicular to the pyloric axis. This multicenter retrospective study...
Catheter configuration for mapping micro-anatomic reentries sustaining atrial fibrillation: A simulation study.
Atrial fibrillation (AF) can be sustained by intramural reentrant circuits within three-dimensional arrhythmogenic hubs formed by fibrotically-insulated myobundles. However, the efficacy of different ...
Hyperandrogenism Synergizes With Obesity to Increase the Risk of Hypertensive Disorders of Pregnancy After Frozen Embryo Transfer.
Hyperandrogenism has been linked to increased preeclampsia risk, but its independent role remains unclear due to confounding by polycystic ovary syndrome (PCOS). This retrospective cohort study invest...
The Super Thin External Pudendal Artery Free Flap for Buccal Reconstruction: A Case Report.
Reconstruction of buccal mucosal defects requires thin, pliable, and well-vascularized tissue to preserve oral function and cheek mobility. While the radial forearm free flap remains widely used, alte...
The Effect of the Coexistence of Hair Follicle and Perforator Artery Density on Length of Hospital Stay in Burns.
Whilst total body surface area, burn depth and age are established determinants of hospital stay, the independent influence of the anatomical region's biological microenvironment remains unexamined. T...
S100A9 Aggravates Cardiac Fibrosis by TLR4/PGC-1α Mediated Macrophage-Myofibroblast Crosstalk.
Fibrosis is a critical component of ventricular remodelling after myocardial ischemia, and the activation and expansion of cardiac fibroblasts represent key drivers of this process. Our previous work ...
Panoramic hyperspectral optical mapping of cardiac membrane potential and tissue type.
SIGNIFICANCE: Cardiac panoramic optical mapping is a powerful approach for studying action potential dispersion and mapping arrhythmia triggers and propagation pathways over the entire surface of the ...
Ultrasonographic Measurement of Kidney-to-Aorta Parameters in French Bulldogs.
Ultrasonographic kidney size assessment requires normalization to body size; the kidney length-to-aorta diameter (KL/AoD) ratio improves diagnostic accuracy, yet reference ranges vary across breeds. T...
Change in pulmonary artery pressure upon acute exposure to high altitude: a systematic review and meta-analysis.
BACKGROUND/RESEARCH QUESTION: We investigated the increase in pulmonary artery pressure (PAP) with altitude gain in healthy low-altitude residents travelling to high altitude, analysing reported measu...
Triglyceride-glucose index as a predictor of adverse cardiovascular outcomes in a contemporary, diverse US population undergoing percutaneous coronary intervention.
BACKGROUND AND AIMS: The triglyceride-glucose (TyG) index has emerged as a powerful and accessible marker of insulin resistance and a predictor of adverse events in patients undergoing percutaneous co...