Clinical Presentation and Treatment Response in Women With Acetylcholine-Confirmed Coronary Spasm: A Single-Center Observational Study.

BACKGROUND: Coronary vasomotor disorders are frequently underdiagnosed in women with angina and non-obstructive coronary arteries. We investigated clinical presentation, diagnostic delay, spasm subtyp...

Artificial Intelligence-Based Analysis of Coronary Atherosclerotic Plaque on Intravascular Ultrasound: A Systematic Review and Meta-Analysis.

BACKGROUND: Coronary atherosclerotic plaque detection is essential for the diagnosis and management of coronary artery disease. Although intravascular ultrasound (IVUS) enables detailed plaque assessm...

Aortic Root Geometry and Valve Competence After Aortic Valve Neocuspidization: Insights From the Sinotubular Junction-to-Annulus Ratio.

OBJECTIVES: Aortic valve neocuspidization, or the Ozaki procedure, is an alternative to prosthetic valve replacement. However, the association between native aortic root geometry, particularly the sin...

A Homozygous Founder ELAC2 Variant in Kuwaiti Infants With Fatal Cardiomyopathy and Refractory Severe Lactic Acidosis: A Retrospective Review of the Clinical, Cardiological and Molecular Findings.

BACKGROUND: Infantile-onset cardiomyopathy due to mitochondrial dysfunction is a severe condition frequently associated with poor prognosis. Biallelic pathogenic variants in ELAC2, an essential mitoch...

Hemoglobin Glycation Index and Prognosis in Patients With Acute Myocardial Infarction Without Reduced Left Ventricular Ejection Fraction: A Multicenter Retrospective Cohort Study.

BACKGROUND: The prognostic value of the hemoglobin glycation index (HGI) in patients with acute myocardial infarction (AMI) without reduced left ventricular ejection fraction (LVEF) remains unclear. M...

Atrial Cardiopathy in Embolic Strokes of Undetermined Source.

BACKGROUND: Embolic Strokes of Undetermined Source (ESUS) accounts for about 9-25% of all ischemic strokes. Atrial cardiopathy (AC) is a recently described pathology of the left atrium and is found to...

The Pretemporal Transcavernous Approach to the Posterior Clinoid Process Chondrosarcoma with Intraoperative Neuromonitoring.

The pretemporal transcavernous approach (PTTCA) is used for complex aneurysms and skull base tumors. Four levels of PTTCA have been described depending on the extent of exposure of the cavernous sinus...

Myocardial Stress Biomarkers and Inflammatory Indices in Cattle With Bovine Respiratory Disease Complex.

BACKGROUND: Bovine respiratory disease complex (BRDC) is primarily considered a pulmonary disorder; however, hypoxia and systemic inflammation associated with this condition may also impose cardiovasc...

Disease-Phase Myocardial Dysfunction by Strain Imaging in Kawasaki Disease: A Systematic Review and Meta-Analysis.

BACKGROUND: Global longitudinal strain (GLS) can detect subclinical dysfunction missed by left ventricular ejection fraction (LVEF). We aim to quantify the magnitude of myocardial dysfunction using GL...

L-DOPA Promotes Post-Treatment Neurovascular and Synaptic Homeostasis in Early Diabetic Retinopathy.

PURPOSE: Although previous work has shown a post-treatment protective effect of levodopa (L-DOPA) on retinal function in early-stage diabetic retinopathy (DR) in humans, its underlying biology is unkn...

Qiliqiangxin Improves Cardiac Glucose Metabolism After Myocardial Infarction Through a HIF-1α/MIF/AMPK Axis.

Cardiac glucose metabolism is critically involved in the pathophysiology of myocardial infarction. This study investigated whether Qiliqiangxin (QL), a traditional Chinese medicine, improves myocardia...

Cardiac Rehabilitation for Cardiovascular Risk Modification in Patients With Rheumatoid Arthritis and Hypertension: A Randomized Controlled Trial.

OBJECTIVE: Patients with rheumatoid arthritis (RA) have an increased risk of cardiovascular disease, particularly when hypertension coexists. However, evidence regarding the role of cardiac rehabilita...

Conditional ablation of RGS2 in myeloid cells does not influence blood pressure and organ damage in angiotensin II-induced hypertension in mice.

The role of the immune system in the development of hypertension is well-established. Recent studies revealed the critical role of G-protein-coupled receptor signaling, particularly angiotensin II (An...

Echocardiographic Probability of Pulmonary Hypertension, Cardiac Structural Alterations and All-Cause Mortality in Maintenance Hemodialysis Patients: A Single-Center Retrospective Cohort Study With Competing Risk Analysis.

BACKGROUND: Maintenance hemodialysis (MHD) patients carry extremely high cardiovascular mortality, where pulmonary hypertension (PH) and vascular access are critical prognostic factors. However, previ...

Epidemiological Trends in Mortality From Acute Myocardial Infarction With Essential and Secondary Hypertension: CDC WONDER Database Analysis, 2000-2024.

BACKGROUND: Acute myocardial infarction (AMI) with essential hypertension (EH) and secondary hypertension (SH) remains a leading cause of mortality. Despite the overall decline, disparities in mortali...

Center Differences in PreTransplant Functional Status and Its Association With Survival After Heart Transplantation.

BACKGROUND: The Karnofsky Performance Scale (KPS) is widely used to assess functional status in heart transplantation (HT) candidates and inform risk stratification. However, its subjective nature rai...

Effects of Combined Training on Cardiac Autonomic Modulation in Asthmatic Adolescents.

OBJECTIVE: Exercise-induced bronchoconstriction (EIB) is defined as the acute narrowing of the lower respiratory airways after exercise. This study aimed to verify the behavior of cardiac autonomic mo...

Development and validation of a predictive model for the severity of hyperlipidemic acute pancreatitis based on the bedside index for severity in acute pancreatitis and metabolic score for insulin resistance: A retrospective cohort study.

ObjectivesHyperlipidemic acute pancreatitis progresses rapidly to severe acute pancreatitis. Early identification of disease severity is critical for improving outcomes. This study aimed to investigat...

Temporal Trends and Disparities in Hypertension-Related Cardiomyopathy Mortality in the United States, 1999-2023.

BACKGROUND: Hypertension and cardiomyopathy are major contributors of cardiovascular morbidity in the United States. This study investigates long-term mortality trends and disparities in hypertension-...

More Than a New Heart: Psychological Adjustment and Quality of Life Following Heart Transplantation, a Mixed-Methods Study.

INTRODUCTION: Heart transplantation (HTx) offers life-saving treatment for advanced heart failure. While physical recovery is well-documented, psychological recovery and health-related quality of life...