Reduced Complement and Granulocyte Activation by α-Gal Knockout Porcine Pericardium for Bioprosthetic Heart Valves: A Pilot Hemocompatibility Study.

Xenogeneic pericardium is the main source for biological aortic valve prostheses. Immune responses to α-Gal epitopes and free aldehyde groups after glutaraldehyde (GA) fixation are responsible for the...

Hydroxychloroquine and the cardiovascular system: lights and shadows.

OBJECTIVES: To review the dual impact of hydroxychloroquine (HCQ) on the cardiovascular system, focusing on both its cardioprotective effects and potential cardiotoxicity in patients with autoimmune d...

Computed Tomography Angiography-Based Mapping of Septocutaneous Fibular Artery Perforators: An Anatomical Analysis.

BACKGROUND: Reliable localization of septocutaneous fibular artery perforators is essential for fibula free flap planning. However, the influence of lower-leg vascular anatomy on perforator number and...

Association Between the Red Blood Cell Distribution Width-to-Albumin Ratio, Nursing Notes, and the Length of Hospital Stay in Iron Deficiency Anaemia Complicated With Congestive Heart Failure Patients.

AIMS: To evaluate the influence of the red blood cell distribution width-to-albumin ratio (RAR) and sentiment scores from nursing notes on the length of hospital stay (LOS) and mortality risk among ir...

Admission Phenotype Clarifies the Apparent Prognostic Contrast Between TOAST Etiologic Subtypes in Large-Core Anterior-Circulation Large-Vessel Occlusion.

OBJECTIVE: In large-core anterior-circulation large-vessel occlusion (LVO), differing admission clinical-imaging profiles complicate interpretation of prognostic differences between large-artery ather...

Diagnosis-to-Ablation Time and Atrial Arrhythmia Recurrence After Ablation.

IMPORTANCE: Diagnosis-to-ablation time (DAT) has emerged as a potential predictor of ablation outcomes in atrial fibrillation (AF). Limited evidence is available on the association of prolonged DAT, a...

Vascular-Apoptotic Crosstalk in Alzheimer's Disease: The Possible Role of Vascular Senescence in Blood-Brain Barrier Dysfunction.

BACKGROUND: Blood-brain barrier (BBB) dysfunction is an early feature of Alzheimer's disease (AD), influenced by amyloid pathology, astrocyte activation, and vasoactive mediators such as endothelin-1 ...

Genetic association of rs373001 polymorphism in mir-130b gene with susceptibility to dyslipidaemia and correlation with lipid profile.

OBJECTIVE: To find the association and correlation of rs373001 polymorphism in micro-ribonucleic acid-130b gene with the risk of dyslipidaemia. METHODS: The case-control study was conducted from April...

Hyperlipidaemia and its future prospective in district Gujrat, Pakistan: a retrospective study.

OBJECTIVE: To evaluate the prevalence of hyperlipidaemia with respect to age and gender, and to assess future prospects. METHODS: The retrospective study was conducted in October 2024 at Dr Abdul Rauf...

Heart Transplant for Noncompaction Cardiomyopathy in NONO-Related Syndromic Intellectual Disability.

INTRODUCTION: Loss-of-function variants in NONO cause an X-linked syndromic neurodevelopmental disorder (MRXS34), characterized by developmental delay, corpus callosum abnormalities, dysmorphic featur...

Healthcare provider experiences integrating mental illness screening and management into hypertension care: qualitative systematic review.

Mental illness is a frequent comorbidity in chronic diseases including hypertension, yet integration of mental health screening into hypertension care remains limited, particularly in low- and middle-...

Association of C-Reactive Protein-Triglyceride Glucose Index and TyG Index With Prehypertension and Hypertension.

This study aimed to investigate the associations of the C-reactive protein-triglyceride glucose index (CTI) and the triglyceride-glucose (TyG) index with prehypertension and hypertension in a Chinese ...

Effectiveness of Nurse-Led atrial Fibrillation Detection for Patients With Embolic Stroke of Unknown Source in Stroke Units: A Retrospective Study.

BACKGROUND: Atrial fibrillation is a primary cause of ischemic stroke, necessitating early detection, particularly in patients with embolic stroke of undetermined source. While nurseled continuous ele...

Hospitalization for Malignant Arrhythmias Following Initiation of Donepezil: A Retrospective Cohort Study.

PURPOSE: Limited evidence suggests donepezil might pose an increased risk of malignant arrhythmias. We examined whether donepezil initiation was associated with a higher risk of hospitalization for ma...

Quantifying Lateral Pulsation in Retinal Vessels Within the Optic Disc.

PURPOSE: The retina provides a noninvasive window for imaging vascular pulsation in the optic disc. Pulsation characteristics reflect vascular stiffness, hemodynamics, and ocular pressure dynamics, us...

The Effect of Chronic Angiotensin (1-7) Treatment on Functional Responses of Isolated Resistance Arteries in Streptozotocin-Induced Diabetic Rats.

Cardiovascular complications of diabetes mellitus (DM) are responsible for morbidity and mortality in DM patients. Recent evidence highlights the pathophysiological role of the renin-angiotensin-aldos...

Failed Ventrain Device! Spontaneous Bag-Mask Ventilation Revisited as a Rescue Procedure in a Case of Recurrent Tracheal Stenosis with Dilated Cardiomyopathy.

This case report discusses the anesthetic management of a 47-year-old female with recurrent adenocystic carcinoma of the trachea and dilated cardiomyopathy (DCMP) undergoing tracheal tumor debulking a...

Guidewire Obstruction of Centrifugal Pump, in Patient on Extracorporeal Circulatory Support.

This case report tells the story of a 36-year-old overweight male with suspected myocarditis, who goes into cardiac arrest, and is subsequently transported to a heart center for extracorporeal membran...

Immune-Endocrine crosstalk in hypertensive overweight men: Dysregulation of IL-17 and IL-40-mediated inflammatory pathways.

Hypertension belongs to the category of serious health concerns among overweight people that are frequently attributed to chronic low-grade inflammation. The present study investigated the significanc...

Harbinger of Difficult Weaning from Cardiopulmonary Bypass in Aortic Valve Replacement Surgery: A Case Report.

Failure to wean from cardiopulmonary bypass (CPB) is a rare but critical intraoperative challenge. Common causes include residual structural defects (causing intracardiac shunting, prosthetic valve le...