Emerging Roles for Metabolism in Myocardial Inflammation During Heart Failure.
Metabolic alterations are a hallmark of heart failure and differ across stages. The immune system plays a critical role in cardiac repair and injury during heart failure progression. Metabolic interac...
Unilateral High-Riding Vertebral Artery Associates With the Progression of Atlantoaxial Joint Degeneration in Patients With Rheumatoid Arthritis.
High-riding vertebral artery (HRVA) at C2 is more prevalent in patients with rheumatoid arthritis (RA) than in the general population, but its clinical significance remains unclear. Recent evidence in...
Early Left Ventricular Mechanical Dyssynchrony Predicts Left Atrial Dysfunction Following Right Ventricular Pacing.
BACKGROUND: Left atrial reservoir strain (LASr) is an established marker of left atrial (LA) mechanical dysfunction and may identify early remodeling preceding HFpEF in patients undergoing conventiona...
Moving the Goalposts in Hypertensive Risk Assessment: The AVI/LVGLS Ratio as a Sensitive Detector of Maladaptive Ventricular-Arterial Coupling.
PURPOSE: This commentary discusses the AVI/LVGLS ratio as an emerging, fully non-invasive marker of ventricular-arterial coupling (VAC) for refining cardiovascular risk assessment in hypertension beyo...
2D-Echocardiographic Estimation of Right Ventricular Volumes Using a Previously Validated Geometric Model Is Associated With Outcomes After Transcatheter Tricuspid Interventions.
AIMS: To determine whether a simplified, previously proposed two-dimensional (2D) approach to RV volume assessment can provide adjunctive prognostic information in patients undergoing Transcatheter Tr...
Association of Echocardiographic Ventricular-Arterial Coupling With Elevated 10-Year ASCVD Risk in Hypertensive Patients.
OBJECTIVE: To investigate the association between the arterial velocity pulse index-to-left ventricular global longitudinal strain ratio (AVI/LVGLS) and estimated 10-year atherosclerotic cardiovascula...
[A case report of seronegative dermatomyositis primarily presenting as severe myocarditis].
皮肌炎是一种以皮肤和横纹肌受累为主的少见特发性炎性肌病（IIMs）。皮肌炎累及心脏多为无症状或亚临床心脏受累，自身抗体多为阳性。皮肌炎并发重症心肌炎临床少见，却是重要死亡原因。本文报道1例自身抗体阴性皮肌炎并发重症心肌炎病例，以期强化病因识别和鉴别诊断，提供临床参考。.
FLVCR2 Regulation of Intracellular Heme Modulates Vascular Tip/Stalk Specification During Retinal Angiogenesis.
PURPOSE: Fowler syndrome is an embryonic lethal disease with proliferative vasculopathy and hydranencephaly-hydrocephaly of the central nervous system caused by mutations in feline leukemia virus subg...
Glutamate carboxypeptidase II activation in astrocytes mediates glymphatic impairment and cognitive vulnerability in the aging brain following surgery.
INTRODUCTION: Perioperative neurocognitive disorder is a common and debilitating complication in the elderly, yet its cellular and molecular mechanisms in the aging brain remain poorly understood. MET...
Myocardial Immune Niches in Homeostasis and Inflammation.
The heart functions as a circulatory pump that supplies blood throughout the body. The execution of this critical function depends on the interplay between cardiomyocytes and the supportive cellular i...
Colchicine as an Adjunctive Therapy to Improve Ischemic Stroke Reperfusion Outcomes in Mice.
BACKGROUND: Mechanical thrombectomy (MT) has become a cornerstone therapy for acute ischemic stroke (AIS) caused by large-vessel occlusion; however, incomplete microvascular reperfusion and blood-brai...
Precision medicine for atherosclerotic cardiovascular disease: Integrative genomics maps risk loci and AI-predicted functional consequences.
BACKGROUND: Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of global morbidity and mortality, but its genetic architecture remains incompletely understood. This study aims to uncove...
[Clinical application of echocardiography in the diagnosis and treatment of adult pulmonary hypertension: a Chinese guideline (2026)].
Over the past decade, significant advances have been made in the definition, epidemiology, identification of high-risk populations, aetiology, pathophysiology, clinical classification, risk stratifica...
Association of Metabolic Score for Insulin Resistance With Resistant Hypertension and Hypertension in Obstructive Sleep Apnea.
INTRODUCTION: Obstructive sleep apnea (OSA) is common in the presence of hypertension and refractory hypertension (RH); however, the pathophysiological interrelationship of such conditions is yet to b...
Machine Learning With Genetic and Clinical Data to Predict Ischemic Outcomes After PCI.
Ischemic events after contemporary percutaneous coronary intervention (PCI) are uncommon but carry high morbidity/mortality. Identifying patients at highest risk is critical to guide dual antiplatelet...
The Association of Hypertension Based on Systolic and Diastolic Blood Pressure (SBP and DBP) With Dental Visits in the Population Aged 45 and Older: Cross-Section Study Results From the China Health and Retirement Longitudinal Study (CHARLS).
OBJECTIVE: Systemic diseases increasingly complicate oral treatment, particularly in hypertensive patients requiring comprehensive care. Using nationally representative cross-sectional data, this stud...
24-h Movement Behaviors and Incident Hypertension Among Adolescents: A Prospective Study From the ABCD Study.
Hypertension during adolescence is a growing public health concern with long-term cardiovascular implications. This study examined whether adherence to 24-h movement behavior guidelines-physical activ...
The Association Between Bending Photoplethysmography Waveform Area Index and Congestive Heart Failure.
AIMS: Congestive heart failure (CHF) is closely associated with a decrease in cardiac output, and photoplethysmography (PPG) parameters can experimentally assess cardiac output. It is unclear whether ...
The Barthel Index in Predicting Response to Cardiac Resynchronization Therapy and Clinical Outcomes in Patients With Heart Failure.
BACKGROUND: Cardiac resynchronization therapy (CRT) response in heart failure (HF) patients is multifactorial, with limited data on its association with activities of daily living assessed by the Bart...
Identification of the MYH6 c.804G>C Synonymous Variant Causing Exon Skipping in a Hypertrophic Cardiomyopathy Family.
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a common hereditary cardiac disorder characterized by left ventricular hypertrophy, outflow tract obstruction, arrhythmias, and increased risk of sudde...