A novel dynamic Optuna hybrid Harris Hawks Optimization approach for classification of CAD.
Coronary Artery Disease (CAD) is a leading cause of mortality worldwide and is primarily associated with atherosclerotic plaque formation, resulting in coronary artery stenosis. The accurate predictio...
Association of the combined triglyceride glucose-body mass index and serum IQGAP3 in appraising coronary lesion severity in type 2 diabetes.
BACKGROUND: IQGAP3 is a novel scaffold protein involved in inflammatory and metabolic regulation and may contribute to atherosclerosis. However, its clinical significance in coronary artery disease am...
Magnetocardiography for Exploratory Risk Stratification in Patients With Three-Vessel Coronary Artery Disease: A Single-Center Prospective Cohort Study.
BACKGROUND AND AIMS: Patients with three-vessel coronary artery disease (3V-CAD) remain at heterogeneous risk for major adverse cardiovascular and cerebrovascular events (MACCE) after revascularizatio...
The oral and lower airway microbiota and coronary heart disease in COPD patients and controls.
BACKGROUND: Chronic obstructive pulmonary disease (COPD) and coronary heart disease (CHD) are major causes of morbidity and mortality, with shared risk factors and often co-occurring. This study inves...
Safety and Feasibility of a Simplified Perioperative Hemodialysis Protocol in Hemodialysis Patients Undergoing Off-Pump Coronary Artery Bypass Grafting.
PURPOSE: Patients on hemodialysis (HD) undergoing coronary artery bypass grafting (CABG) face a high risk of perioperative complications, and the optimal timing of perioperative HD remains unclear. We...
Multi‑feature Prediction Model for Coronary Heart Disease Comorbidity in Middle‑aged and Older Adults with COPD Based on Machine Learning and SHAP.
BACKGROUND: Chronic obstructive pulmonary disease (COPD) frequently coexists with coronary heart disease (CHD), markedly worsening prognosis in middle-aged and older patients. Early identification of ...
Elevated Hydrocarbon Exposure Escalates Coronary and Cerebrovascular Disease Risks: A Comprehensive Systematic Review.
Exposure to hydrocarbons, including polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs), represents an escalating public health concern. These compounds induce systemic infla...
Association of serum 25-hydroxyvitamin D levels with indicators of target organ damage in patients with diabetes: a cross-sectional study.
OBJECTIVE: To assess serum 25-hydroxyvitamin D [25(OH)D] in relation to indicators of target organ damage in patients with diabetes. METHODS: This analysis included 372 adults with diabetes who underw...
Nomogram model for predicting multivessel disease in coronary artery disease using cardiac function parameters and clinical features.
BACKGROUND: Multivessel disease (MVD) represents a severe phenotype of coronary artery disease and is associated with poor prognosis. Early, non-invasive identification of MVD remains a clinical chall...
Degree of hypertension and subclinical coronary atherosclerosis in asymptomatic individuals without cardiovascular disease.
OBJECTIVE: This study sought to evaluate the association between degree of hypertension and subclinical coronary atherosclerosis. DESIGN AND METHOD: We analyzed 7,332 asymptomatic individuals (mean ag...
Genetic Links Between Cancer and Coronary Atherosclerosis: A Mendelian Randomization Analysis.
BACKGROUND: While observational studies have indicated a potential link between cancer and coronary atherosclerosis, the relationship remains obscured by confounding factors. Elucidating a shared gene...
Genetic yield of next-generation sequencing for detecting monogenic familial hypercholesterolemia in uzbek patients with coronary artery disease.
BACKGROUND: Familial hypercholesterolaemia (FH) is an inherited disorder with markedly elevated LDL-C and increased risk of premature atherosclerotic cardiovascular disease, most often caused by patho...
Basement Membrane-Related Genes C1QTNF3, PTGER2, CAMK2N1, PRSS36, and B3GNT7: Novel Biomarkers for Coronary Artery Disease.
BACKGROUND: Basement membrane-related genes (BMRGs) play a pivotal role in the pathogenesis of several diseases. However, their association with coronary artery disease (CAD) remains unexplored. There...
Best evidence summary of digital health interventions for self-management in patients with coronary artery disease.
OBJECTIVE: To systematically identify and synthesize the best available evidence on digital health interventions supporting self-management in patients with coronary artery disease (CAD). The aim of t...
Association between impaired peripheral thyroid hormone sensitivity and coronary heart disease in type 2 diabetes: the potential mediating role of albumin.
BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with a high risk of cardiovascular mortality, primarily from coronary heart disease (CHD). Thyroid hormone (TH) sensitivity and albumin indepe...
Integrating lipid-related composite indices and explainable machine learning for coronary heart disease risk assessment.
BACKGROUND: Composite indices integrating inflammation and lipid metabolism have emerged as promising markers for coronary heart disease (CHD), yet their comparative performance and discriminative abi...
Association Between Apelin Gene -1860T>C (rs56204867) Polymorphism and Coronary Artery Disease in a Syrian Cohort.
PURPOSE: Apelin is a secreted peptide hormone involved in vasodilation, fluid homeostasis, and angiogenesis, and is therefore considered an important regulator of cardiovascular physiology. The APLN T...
Triglyceride-glucose related index and its association with coronary heart disease risk in patients with metabolic dysfunction-associated steatotic liver disease: a retrospective analysis based on type 2 diabetes mellitus.
BACKGROUND: The triglyceride-glucose (TyG) related index, as an emerging indicator of insulin resistance, has been shown to be closely associated with the clinical status (incidence of cardiovascular ...
Association of the TyG index and its body fat distribution composites with CHD and MACE risk in adults with OSAHS: incremental discrimination and exploratory mediation analysis.
INTRODUCTION: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is closely associated with coronary heart disease (CHD) and adverse cardiovascular outcomes, but the comparative value of the triglyceri...
Effects of Positive Event Recording on Rehabilitation Outcomes in Elderly Patients with Coronary Heart Disease and Anxiety.
BACKGROUND: Elderly patients with coronary heart disease (CHD) are prone to psychological disorders during treatment. Strengthening psychological well-being can improve rehabilitation outcomes. This s...