Macrophage-Driven Bidirectional Exacerbation in Psoriasis-Atherosclerosis Comorbidity: Insights From a Novel Mouse Model.

BACKGROUND: Psoriasis (PSO) and atherosclerosis (AS) are chronic inflammatory diseases that frequently coexist, with each condition exacerbating the other. However, the underlying mechanisms remain po...

[Markers of metabolic and mitochondrial stress in atherosclerosis with consideration of age-related aspects: Clinical applicability and translational limitations (literature review).].

The purpose of this review is to summarize and critically analyze data on markers of metabolic and mitochondrial stress in atherosclerosis in older and oldest-old patients, highlighting differences be...

PANoptosis links gut dysbiosis to obstructive sleep apnea-associated atherosclerosis: a gut-vascular inflammatory axis.

Obstructive sleep apnea (OSA) is increasingly recognized as an independent contributor to atherosclerotic cardiovascular disease, yet the mechanisms linking nocturnal intermittent hypoxia (IH) to plaq...

Dihydrotanshinone I Attenuates Atherosclerosis via Inhibiting NLRP3 Inflammasome Activation and Modulating Gut Microbiota.

Atherosclerosis (AS), a primary contributor to cardiovascular disease, is driven by hyperlipidemia, chronic inflammation, and gut dysbiosis. Although Salvia miltiorrhiza Bunge (Danshen) has long been ...

Development and validation of a nomogram for predicting peripheral atherosclerosis in early-stage type 2 diabetic kidney disease: a retrospective hospital-based study.

INTRODUCTION: Microvascular disease is a common complication of type 2 diabetes mellitus (T2DM). As a typical microvascular complication, diabetic kidney disease (DKD) interacts with peripheral athero...

Research progress on targeted regulatory proteins in the prevention and treatment of atherosclerosis.

Atherosclerosis (AS) is a chronic inflammatory disease characterized by lipid metabolic dysregulation and vascular cell phenotypic switching. Its progression is governed by intricate interactions betw...

Microbiota-mediated mechanisms of natural products in atherosclerosis: focus on metabolic and inflammatory pathways.

BACKGROUND: Atherosclerosis (AS) is a chronic inflammatory vascular disease characterized by lipid accumulation, endothelial dysfunction, immune dysregulation, and plaque formation. Beyond conventiona...

Ferroptosis in arterial atherosclerosis: mechanistic hypotheses, cell type specific vulnerabilities, translational biomarkers, and therapeutic opportunities.

Despite significant progress in lipid-lowering and anti-thrombotic therapies, atherosclerosis remains a leading cause of myocardial infarctions and ischemic strokes. Residual risk persists, often link...

Five-Year Outcomes of Paclitaxel-Coated Balloons in Patients with Diabetes from the BIOLUX P-III Single-Arm Study.

PURPOSE: Long-term outcomes of paclitaxel-coated drug-coated balloons (DCBs) in patients with diabetes mellitus (DM) and infrainguinal peripheral arterial disease (PAD) are incompletely defined. In th...

Mediation by atherogenic index of plasma of the association between body roundness index and cognitive impairment in older Chinese people: an analysis using health check-up data.

OBJECTIVE: The objective of this large sample cross-sectional study was to investigate the relationships between body roundness index (BRI), atherogenic index of plasma (AIP), and cognitive impairment...

Cardiovascular risk in inflammatory bowel disease: focus on lipids and visceral adipose tissue.

Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are chronic immune-mediated diseases that are increasingly recognized as systemic diseases with significant cardiov...

Japanese-Style Diet and LOX-Index in Japanese Municipal Workers.

Japanese-style diet has been reported to be associated with decreased risk of cardiovascular disease. However, no study has examined the association between a Japanese-style diet and LOX-index, which ...

[The role of lipid metabolism disorders in the activation of cellular aging markers in atherosclerosis in elderly and senile individuals.].

Atherosclerosis is considered as one of the leading age-associated diseases, the development of which is closely related to disorders of lipid metabolism, chronic inflammation and activation of cellul...

The association of eicosanoids with lung structure and function: Findings from the Multi-Ethnic Study of Atherosclerosis lung study and Framingham Heart Study.

BACKGROUND: Eicosanoids are bioactive signaling lipids that have roles in airway remodeling, smooth muscle hypertrophy, emphysema and pulmonary fibrosis via mediation of pro- and anti-inflammatory pat...

Patient quality of life determinants in decision-making regarding amputation.

BACKGROUND: Psychological adjustment to amputation begins well before surgery and is pivotal in determining both functional and emotional outcomes. For patients with Peripheral Arterial Disease (PAD),...

Bone marrow cellular profile in patients with diabetes: association of statin therapy with CD34+ cells.

BACKGROUNDS: Diabetes is associated with alterations in bone marrow (BM) cellularity beyond its acute and chronic complications in both type 1 and type 2 diabetes. These changes may be amplified in pa...

Clustering Analysis of Ankle-Brachial Index Related Metabolic and Body Composition Profiles Using K-Means Approach.

PURPOSE: The Ankle-brachial Index (ABI) is a non-invasive diagnostic tool used to assess peripheral perfusion disorders. However, the increasing number of clinical parameters involved in ABI assessmen...

OxLDL-induced ferroptosis and pyroptosis in atherosclerosis: a mini review.

Oxidized low-density lipoprotein (oxLDL) is a central driver of inflammatory responses in atherosclerosis and triggers multiple forms of regulated cell death beyond classical apoptosis. Ferroptosis, c...

The Association of Race and Ethnicity with Six-Minute Walk Distance: The Multi-Ethnic Study of Atherosclerosis.

BACKGROUND: The limited data on functional capacity among older Americans suggest lower 6-min walk distance (6MWD) among African American than among White persons. We aimed to investigate the associat...

Screening and comprehensive analysis of endoplasmic reticulum stress-related biomarkers in atherosclerosis.

Atherosclerosis (AS) is a chronic inflammatory vascular disorder in which endoplasmic reticulum stress (ERS) plays a crucial regulatory role. However, the biological and translational relevance of ERS...