BMI-specific nonlinear associations and threshold effects of the atherogenic index of plasma on incident prediabetes: insights from 100473 Chinese adults.
BACKGROUND: Emerging evidence suggests that the atherogenic index of plasma (AIP), a simple marker of lipid-related metabolic risk, may relate to dysglycemia in a nonlinear fashion. However, whether t...
Gut microbiota dysbiosis-induced chronic inflammation as a driver of atherosclerosis: cellular crosstalk and host-microbe interactions.
Gut microbiota dysbiosis is increasingly recognized as an upstream contributor to chronic low-grade inflammation and atherosclerosis (AS). Disruption of microbial homeostasis may impair intestinal bar...
Association between Serum Neurofilament Light Chain Levels and the Predicted 10-Year Atherosclerotic Cardiovascular Disease Risk.
This cross-sectional study aimed to examine the association between serum neurofilament light chain (sNfL) and the PCE-estimated 10-year atherosclerotic cardiovascular disease (ASCVD) score using data...
Cost-effectiveness of inclisiran in patients with atherosclerotic cardiovascular disease from Chinese healthcare perspective.
BACKGROUND: Atherosclerotic cardiovascular disease (ASCVD) imposes a substantial clinical and economic burden in China. Despite maximally tolerated statin therapy, many patients fail to achieve recomm...
Neutrophil extracellular traps and pyroptosis: a molecular nexus linking systemic autoimmune diseases to atherosclerosis.
This review aims to elucidate the molecular mechanisms of neutrophil extracellular traps (NETs) and pyroptosis, exploring their synergistic role as a pathological nexus bridging systemic autoimmune di...
Glycolysis and neutrophil extracellular traps in atherosclerosis: Mechanisms, association, and therapeutic strategies.
Atherosclerosis (AS) is a chronic inflammatory disorder of the medium and large arteries, characterized by lipid accumulation within the arterial wall and a sustained inflammatory milieu, and it remai...
Ultra-processed foods, lifestyle management, and cardiovascular diseases.
Ultra-processed foods (UPFs) have increasingly displaced traditional diets globally and have become a significant public health concern, particularly in relation to cardiovascular (CV) diseases. UPFs ...
Vascular Aging.
Vascular aging is a central determinant of healthy life span, not only influencing the susceptibility to cardiovascular diseases but also shaping the risk of systemic decline across multiple organs. I...
Mechanisms and therapeutic potential of colchicine in atherosclerotic cardiovascular disease.
Over the past decade, colchicine has re-emerged as a promising therapeutic candidate for atherosclerotic cardiovascular disease. Here we review evidence from large randomized controlled trials togethe...
Advanced maternal age at first delivery as a risk factor for long-term cardiovascular disease.
An increased numbers of women initiate motherhood at an advanced age. Advanced maternal age (AMA) at first delivery poses unique clinical challenges; however, limited literature exists regarding poten...
The immunometabolic role of pyruvate dehydrogenase kinase/pyruvate dehydrogenase axis in cardiovascular disease and beyond.
The pyruvate dehydrogenase kinase (PDK)/pyruvate dehydrogenase (PDH) axis plays a pivotal role in regulating cellular energy metabolism, controlling the flux between the tricarboxylic acid cycle and o...
mRNA medicine for cardiovascular disease.
Cardiovascular disease (CVD) remains the leading cause of global mortality, prompting urgent efforts to explore novel therapeutic approaches. The remarkable success of mRNA technology brings new possi...
Association Without Causation: The Complex Relationship Between Sleep Disordered Breathing and Cardiovascular Disease.
Mitochondria-Derived Vesicles and Mitochondrial Extracellular Vesicles in Health and Cardiovascular Disease.
Mitochondria-derived vesicles (MDVs) and mitochondrial extracellular vesicles (mitoEVs) represent 2 related extensions of mitochondrial dynamics that link organelle maintenance to communication within...
Mitochondrial Transfer: From Bench to Bedside.
Intercellular mitochondrial transfer has emerged as a fundamental mechanism of tissue adaptation and repair in the cardiovascular system, with major implications for cardiovascular, neurological, meta...
Intercellular Mitochondrial Transfer: Implications in Cardiovascular Health.
Mitochondria are important organelles for metabolic homeostasis, cell fate, and survival. Emerging evidence suggests that mitochondria are not confined to the cells. Intercellular mitochondrial transf...
Rethinking Mitochondria: The Extracellular Dimension.
Mitochondria are essential organelles that transform the energy contained in metabolic substrates into ATP while supporting numerous cellular processes. Traditionally regarded as strictly intracellula...
Statin Eligibility According to Atherosclerotic Cardiovascular Disease Risk in the US-Reply.
Statin Eligibility According to Atherosclerotic Cardiovascular Disease Risk in the US.
Thyroid dysfunction and cardiovascular disease.
Thyroid hormones play an important role in regulating the cardiovascular system. Thyroid dysfunction, which encompasses hypothyroidism and hyperthyroidism, is relatively common and has been linked to ...