The Landscape of Centralization in Endovascular Care for Peripheral Arterial Disease: A National Cross-Sectional Study.

IntroductionPeripheral arterial disease (PAD) is highly prevalent among cardiovascular diseases. However, the distribution and volume of endovascular diagnostic and therapeutic procedures among instit...

Delving into pyroptosis in atherosclerosis: role, mechanisms and therapeutic opportunities.

Atherosclerosis is a chronic inflammatory condition that represents the primary culprit of multiple cardiovascular diseases. Pyroptosis is a modality of programmed cell death that is elicited by, and ...

Predictors of atherosclerosis and dyslipidaemia among patients with thyroid disease: a cross-sectional analysis.

BACKGROUND: Thyroid dysfunction is a risk factor for cardiovascular disease through its effects on lipid metabolism and arterial wall remodelling. However, the relative contributions of thyroid autoim...

The CD47 signaling axis regulates the formation and vulnerability of atherosclerotic plaques: mechanism analysis and targeting strategies.

CD47-centered signaling, involving the functionally distinct CD47-SIRPα and TSP-1-CD47 axes, has been increasingly implicated in the regulation of vascular inflammation, cellular clearance, and athero...

The potential role of trained immunity in HIV-associated atherosclerotic cardiovascular disease: mechanisms and therapeutic implications.

BACKGROUND: People living with HIV (PLWH) exhibit a markedly elevated risk of developing atherosclerotic cardiovascular disease (ASCVD), a phenomenon not entirely attributable to conventional risk fac...

CASP1 as a key autophagy-related gene in atherosclerosis: Identification by bioinformatics analysis and experimental validation.

OBJECTIVE: This study identified potential autophagy-related genes (ARGs) in atherosclerosis using bioinformatics strategies, aiming to explore novel therapeutic targets for the clinical management of...

Prodrug Strategies in Atherosclerosis: Targeted Delivery and Therapeutic Advances.

CLEC7A as a potential biomarker of atherosclerotic response to aspirin therapy: a multi-omics analysis.

Many patients with atherosclerotic cardiovascular disease (ASCVD) do not respond well to aspirin therapy. This study employed a multi-omics approach to identify key genes associated with aspirin non-r...

Protein acetylation in atherosclerosis: beyond inflammation to core cellular processes and therapeutic potential.

Atherosclerosis (AS) is the leading cause of cardiovascular disease-related mortality worldwide and serves as the core pathological basis for cardiovascular events. Protein acetylation, a widespread a...

Development of a Prognostic Model for MACE in Atherosclerosis Based on MTHFR and Serum Markers.

Background and AimsAtherosclerosis (AS) is associated with high residual cardiovascular risk despite standard treatment. Abnormal homocysteine metabolism and MTHFR polymorphisms are involved in AS pro...

A Cross-Sectional Analytical Study: Prevalence and Clinical Profile of Metabolic Syndrome Among Middle Eastern, Mainly Jordanians, Cohort Presented with Atherosclerotic Cardiovascular Disease.

BACKGROUND: Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of mortality for people living in the Middle East and North Africa (MENA) region. Accumulation of modifiable ASCVD ...

The association between atherogenic index of plasma, cumulative atherogenic index of plasma and type 2 diabetes mellitus with chronic kidney disease among older Chinese adults: Findings from the CHARLS study.

BACKGROUND: The impact of short-term atherogenic burden and long-term cumulative lipid exposure on the risk of incident T2DM with CKD remains unclear. This study examines the longitudinal associations...

Screening of Anti-Atherosclerosis Targets of Ce-Bai-Si-Wei Decoction Based on Multidimensional Data and Study on Cellular Distribution.

BACKGROUND: Atherosclerosis (AS), which causes chronic inflammation, aberrant lipid metabolism and vascular endothelial damage, is the main cause of cardiovascular disease. The Ce-Bai-Si-Wei decoction...

Integrating Network Pharmacology and In Vitro Experiments to Elucidate the Antiatherosclerotic Mechanisms of Qingxin Tongmai Yin.

Qingxin Tongmai Yin (QXTMY), a classic traditional Chinese medicine (TCM) formula widely used for cardiovascular and cerebrovascular diseases, has unclear multitarget mechanisms against atherosclerosi...

Bioinformatics and experimental studies of atherosclerosis-related endothelial dysfunction genes in renal calculi and exploration of their molecular mechanisms.

Patients with kidney stones (KS) often have an increased risk of atherosclerosis (AS). Because endothelial dysfunction (ED) is closely associated with AS, its role in KS remains unclear. This study ai...

A New Mechanism of ox-LDL-Induced Endothelial Cell Pyroptosis.

Endothelial cell pyroptosis is a key factor promoting plaque instability in atherosclerosis (AS). Serum/Glucocorticoid Regulated Kinase 1 (SGK1) is upregulated in AS, but its upstream regulatory mecha...

Microbiota-innate immune crosstalk drives atherosclerosis: mechanisms, disease progression, and emerging therapeutic strategies.

Atherosclerosis (AS) is a complex cardiovascular disease driven by the interplay of dysregulated lipid metabolism, chronic inflammation, and immune dysfunction. Increasing evidence has revealed that t...

The effect of a multimodal multicomponent Prehabilitation program in Older adults with Chronic limb-threatening Ischemia (POCI-study): A study protocol for a multicenter randomized controlled trial.

Chronic limb threatening ischemia (CLTI) in older adults is associated with severe morbidity and high mortality. The rising prevalence is largely driven by the aging population and confronts healthcar...

Risk of Peripheral Artery Disease and Venous Thromboembolism in Patients with Neuromyelitis Optic Spectrum Disorder: A Nationwide Population-Based Cohort Study.

BACKGROUND: The relationship between Neuromyelitis optica spectrum disorder (NMOSD) and specific cardiovascular outcomes, particularly macrovascular events such as peripheral artery disease (PAD) and ...

Glutamate administration is associated with aggravated atherosclerosis and altered expression of RAPGEF1, OPN, and MYL7 in High-Fat Diet-Fed ApoE⁻/⁻ Mice.

OBJECTIVE: This study aims to examine whether oral glutamate administration is associated with accelerated atherosclerosis progression in high-fat diet-fed ApoE ⁻ / ⁻ mice and to identify candidate pr...