Comparison of Fatty Acid Binding Protein 3 and Ankle Brachial Index for Predicting Peripheral Artery Disease Outcomes.

Background: Peripheral artery disease (PAD) impacts more than 200 million individuals globally. Despite its prevalence, management remains suboptimal, partly due to the lack of reliable blood-based bi...

Enhanced Anti-Atherogenic Effects of Epicatechin and Hydroxytyrosol in THP-1 Macrophages: An Integrated In Silico and In Vitro Study.

Atherosclerosis is caused by inflammatory processes that alter the permeability of arterial wall cells and leucocyte recruitment, leading to oxidation of low-density lipoproteins in the artery. The us...

MASLD and Atherosclerosis in Patients with Type 2 Diabetes Mellitus: A Systematic Review.

Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is highly prevalent among patients with type 2 diabetes (T2D) and has been increasingly recognized as a potentia...

Development of a new device to measure arterial stiffness and its reliability, and its potential to detect history of cardiovascular events in patients with chronic kidney disease.

Atherosclerosis, which leads to cardiovascular disease (CVD), can progress without any symptoms. To prevent CVD, it is important to detect atherosclerotic lesions early and assess their severity. Athe...

[Untargeted metabolomics-based exploration of potential metabolic biomarkers for subclinical atherosclerosis in metabolic-associated fatty liver disease].

OBJECTIVES: Cardiovascular disease is the most common extrahepatic complication and leading cause of death in metabolic dysfunction‑associated fatty liver disease (MAFLD). However, early metabolic bio...

[Zhuyu Pills restore Th1/Th2 balance mediated by CD1d/iNKT cell axis to alleviate disorders of sebum and blood lipid metabolism].

This study aims to explore the pathogenesis of the comorbidity of atherosclerosis(AS) accompanied by seborrhea and the intervention effect of Zhuyu Pills. A mouse model of AS with seborrhea was constr...

[Mechanistic study on regulation of MAPK/NF-κB pathway axis by Jiangzhi Huaban Decoction based on "Qi meridian-blood collateral" theory in improving polarization state of macrophages in atherosclerotic plaques].

This study aimed to investigate the therapeutic effects of Jiangzhi Huaban Decoction(JZHB) on atherosclerosis(AS) model mice and to explore its potential molecular mechanisms using proteomic analysis....

[Technical aspects of the primary retrograde endovascular intervention in patients with chronic limb threatening ischemia].

UNLABELLED: The aim was to evaluate the efficacy and safety of primary retrograde endovascular intervention in patients with necrotic lesions of the foot caused by chronic limb threatening ischemia. O...

[Complications of loop endarterectomy in operations on the iliofemoral segment: causes and solutions].

Despite good immediate and remote results of endovascular treatment of patients with atherosclerotic lesions of the iliofemoral segment, involvement of the common femoral artery and the distal segment...

[The effect of sulodexide on the quality of life of patients with intermittent claudication: results of a multicenter observational study of ANDANTE].

RELEVANCE: Arterial disease of the lower extremities is a common form of atherosclerosis associated with an increased risk of cardiovascular disease and mortality. Arterial disease of the lower extrem...

[The use of regulatory peptides after femoropopliteal bypass grafting above the knee joint space using a synthetic prosthesis].

INTRODUCTION: Currently, for extensive occlusive lesions of the superficial femoral artery, the treatment of choice is femoropopliteal bypass grafting above the knee joint space. In the absence of a s...

[Endothelial dysfunction in atherosclerosis and chronic venous disease (lecture review)].

The review presents and summarizes current knowledge about endothelial dysfunction in atherosclerosis and chronic venous disease. The data on various biomarkers and methods of studying endothelial dam...

靶向内皮PDK4-EndoMT反馈环路减轻小鼠胸主动脉夹层的发展

胸主动脉夹层是一种高发病率和高死亡率的急性血管疾病。内皮细胞对维持血管稳态至关重要，但内皮-间充质转化在胸主动脉夹层中的作用尚不明确。PDK4（丙酮酸脱氢酶激酶4）作为这一病理细胞命运转换驱动因素的功能也未被阐明。本研究整合了人体主动脉标本和β-氨基丙腈诱导小鼠模型的转录组分析和免疫荧光分析，通过RNA测序和染色质免疫沉淀测定鉴定PDK4为内皮-间充质转化信号的关键下游效应因子。研究发现，转录因子...

运动通过PDE5A介导的血管平滑肌细胞表型转换抑制减轻主动脉夹层

主动脉夹层是一种危及生命的疾病，涉及血管平滑肌细胞从收缩表型向合成表型的病理性转换。尽管运动具有广泛的心血管益处，但其在主动脉夹层发病机制中的作用尚不清楚。本研究旨在确定运动是否通过调节血管平滑肌细胞表型来减轻主动脉夹层，并阐明其潜在的分子机制。在人体主动脉夹层病变组织中，收缩型血管平滑肌细胞标志物（MYH11、CNN1和α-SMA）显著下调，而合成标志物骨桥蛋白上调。在β-氨基丙腈诱导的主动脉夹...

Integrated evaluation of genetic and pharmacological RAGE inhibition reveals a multidimensional therapeutic strategy for diabetic atherosclerosis.

Atherosclerotic vascular disease is the major cause of mortality in type 2 diabetes. This study sought to examine the effects of different receptor for advanced glycation end-products (RAGE)-targeted ...

PCSK9 inhibitor Evolocumab alleviates atherosclerosis progression by suppressing endothelial cell injury via the ROS/MAPK pathway.

Atherosclerosis (AS) progression is closely linked to oxidized low-density lipoprotein (Ox-LDL)-induced endothelial cell injury. This study investigates the molecular mechanism by which the PCSK9 inhi...

Functional capacity improvement and cardiovascular events after lower extremity revascularization.

BACKGROUND: Functional status predicts outcomes in peripheral artery disease (PAD), but the relevance of changes in functional capacity after lower extremity revascularization (LER) and long-term even...

Unmasking silent atherosclerosis in type 2 diabetes: the emerging role of adipocyte fatty acid-binding protein.

Objectives. Atherosclerosis contributes to higher mortality and morbidity in people with diabetes. Preventing future complications largely depends on the early detection of imminent atherosclerosis. T...

Metabolic, inflammatory, and lipoprotein(a)-related risk profiling for incident ASCVD: a multi-biomarker study.

AIMS: Metabolic dysfunction, inflammation, and lipoprotein(a) [Lp(a)] reflect different biomarker domains associated with atherosclerotic cardiovascular disease (ASCVD) risk. We examined the individua...

Early relative glycemic stress trajectories identify a high-risk metabolic phenotype in critically ill patients with atherosclerotic cardiovascular disease: a dual-cohort study.

BACKGROUND: The stress hyperglycemia ratio (SHR) captures acute glucose elevation relative to chronic glycemic background. However, the prognostic value of early dynamic SHR patterns in critically ill...