Patient-Specific In Silico Prediction of Outcomes of Partial Continuous-Flow LVAD Treatment in Peripartum Cardiomyopathy.

Patients with severe peripartum cardiomyopathy (PPCM) often receive mechanical circulatory support with good outcomes. However, mechanisms underlying the functional improvements are poorly understood ...

Cardiac MRI Monitoring of Myocardial Tissue Changes in a Myocarditis Mouse Model with Histologic Validation.

Purpose To evaluate multiparametric cardiac MRI for assessing myocardial inflammation, fibrosis, and spatiotemporal distribution in autoimmune myocarditis, with histologic reference. Materials and Met...

Potential Relationship Between YTHDF3 and CFTR in Myocardial Ischemia-Reperfusion Injury.

Myocardial ischemia-reperfusion injury (MIRI) is a common pathophysiological process in reperfusion therapy following myocardial infarction. It exacerbates myocardial damage and negatively impacts pat...

Perioperative Management of Cancer Patients With Chemotherapy-Associated Takotsubo Cardiomyopathy.

Takotsubo cardiomyopathy (TTC) is a stress-induced cardiomyopathy characterized by transient left ventricular systolic dysfunction in the absence of obstructive coronary artery disease. Although recov...

Sevoflurane Alleviates Hypoxia/Reoxygenation-Induced Myocardial Injury by Regulating miR-300: An In Vitro Study.

The myocardial protective effect of sevoflurane (Sev) has been confirmed, but its potential molecular mechanism remains not fully elucidated. To unravel the functional contribution and mechanistic bas...

Integrated Single-Cell and Machine Learning Analysis Identifies Fibroblast-Associated Hub Genes and Potential Therapeutics in Ischemic Cardiomyopathy.

Ischemic cardiomyopathy (ICM), a leading cause of heart failure, is characterised by complex cellular heterogeneity and a dysregulated microenvironment. A systematic computational dissection of its mo...

Machine Learning-based Model for Major Adverse Cardiac Event Prediction in Patients with Hypertrophic Cardiomyopathy.

Purpose To develop a machine learning-based model to identify patients with hypertrophic cardiomyopathy (HCM) at high risk of major adverse cardiac events (MACEs) and key predictors of model performan...

Homozygous SGCB splice-site variant causes isolated dilated cardiomyopathy through sarcoglycan complex destabilization in East Asians.

Dilated cardiomyopathy (DCM) is a genetically heterogeneous disorder, characterized by ventricular dilatation and impaired systolic function, leading to heart failure and sudden cardiac death. Despite...

Peripartum-Associated Heart Failure Develops Independently of RHOT Proteins.

Pregnancy-associated hemodynamic overload and hormonal changes induce hypertrophy and metabolic remodeling of the maternal heart. Mitochondrial motility, mediated by ras homolog family member T (RHOT)...

State-of-the-art management of ischemic cardiomyopathy: integrating diagnostic pathways, revascularization strategies, and guideline-directed therapy.

Ischemic cardiomyopathy (ICM) is a major cause of cardiovascular morbidity and mortality, characterized by a complex pathophysiological substrate and heterogeneous clinical trajectories. Despite decad...

The Pivotal Role of Plant Derivatives and Eicosanoid Signaling Modulation in Counteracting Cardiomiopathy.

Eicosanoids and their receptors act as key regulators of inflammation, calcium homeostasis, mitochondrial function, and cardiomyocyte survival, thereby contributing to the onset and progression of car...

Clonal reshaping and clinical outcomes after rechallenge in ICI-associated myocarditis: integrated single-cell and TCR repertoire analysis.

BACKGROUND: Immune checkpoint inhibitor-associated myocarditis (ICIAM) poses significant challenges for cancer immunotherapy, particularly regarding the safety and efficacy of immune checkpoint blocka...

Phosphoproteomics distinguishes disease-specific mechanisms for human phospholamban cardiomyopathy reversible by RNA therapy.

Phospholamban (PLN) p.Arg14del (R14Δ/+, also known as R14del) is a pathogenic variant that causes inherited cardiomyopathy. RNA therapy improves cardiac function and survival in murine PLN R14Δ/+. How...

Detection of Vaccine-Derived Spike Protein Associated with Immune Cell Infiltration in the Heart and Liver: A Report of Two Cases.

The rapid development and deployment of COVID-19 genetic vaccines have raised significant concerns regarding their safety and potential to trigger immune reactions against self-tissues. This paper pro...

Targeting Autoimmune Myocarditis with Lemon Balm Extract: In Vivo Molecular Approach.

Due to the complex pathophysiology and serious outcomes of autoimmune myocarditis, we sought to determine whether ethanolic lemon balm extract (LBE) could attenuate disease progression and development...

Effects of Cardiomyopathic Mutations on the Cytoplasmic Tropomyosin Isoform Tpm1.7.

Tropomyosins (Tpm) are the family of actin-binding proteins encoded by four genes in humans. Missense mutations in the TPM1 gene associated with cardiomyopathies have been studied in the sarcomeric is...

[Research progress on the pathogenesis and clinical treatment of cirrhotic cardiomyopathy].

Liver cirrhosis is often accompanied by cardiovascular lesions, including hyperdynamic circulatory states and myocardial lesions. The hyperdynamic circulatory state manifests as increased cardiac outp...

[Melatonin alleviates cardiomyocyte necroptosis in diabetic mice by inhibiting the STING signaling pathway].

OBJECTIVES: To investigate the protective effect of melatonin against diabetic cardiomyopathy (DCM) and whether melatonin regulates cardiomyocyte necroptosis and inflammatory response through the stim...

[Growth differentiation factor 11 attenuates hypoxia/reoxygenation injury in rat H9C2 cardiomyocytes in vitro by inhibiting thioredoxin-1 nitrative inactivation].

OBJECTIVES: To verify the hypothesis that growth differentiation factor 11 (GDF11) attenuates myocardial ischemia/reperfusion (MI/R) injury and explore the underlying mechanism. METHODS: To simulate M...

The Impact of L Arginine's Anti-Apoptotic, Anti-Inflammatory, and Anti-Fibrotic Effects in Modulating Diabetic Cardiomyopathy: The Role of microRNA-155b in the Diagnosis of Diabetic Cardiomyopathy.

Diabetic cardiomyopathy (DC) is a serious health issue. MicroRNA-155b expression dysregulation might be involved in the fibrotic cycle in DC. L-Arginine (l-arg) is reported to have a preferable impact...