Characterization and outcomes of cats with cardiomyopathy undergoing subcutaneous ureteral bypass device placement.

BACKGROUND: Limited data exist on the characterization and outcomes of cats with cardiomyopathy and benign ureteral obstruction treated by subcutaneous ureteral bypass (SUB) placement. HYPOTHESIS/OBJE...

Immune checkpoint inhibitor-induced myasthenia gravis and myocarditis: a fatal immune-related adverse event.

Checkpoint inhibitors, a class of immunotherapeutic agents, have transformed the oncology landscape by targeting immune checkpoints - regulatory pathways that modulate immune cell activity. By inhibit...

Serum metabolomic signatures integrating sphingosine-1-phosphate and tetrahydrocortisone improve prognostic assessment in non-ischemic cardiomyopathy.

INTRODUCTION: Dilated cardiomyopathy (DCM) and left ventricular non-compaction (LVNC) are major non-ischemic cardiomyopathy (NICM) subtypes with heterogeneous outcomes. Conventional clinical and echoc...

DRIVE v3: Command Line Application for Identity-by-Descent Haplotype Clustering in Large Biobank Scale Data.

There is a need for genetic analytical methods that integrate multi-individual identity-by-descent (IBD) tools with phenotypic enrichment testing to discover novel shared haplotypes contributing to di...

Synergistic Cardioprotection of Colchicine and Hyperbaric Oxygen Therapy in a Rat Model of Remote Ischemia-Reperfusion Injury.

PURPOSE: Lower extremity ischemia-reperfusion injury (IRI) triggers systemic inflammation and oxidative stress, causing myocardial remote ischemia-reperfusion injury (MIRI). Current treatments are lim...

Pharmacokinetic Characteristics of 6-Hydroxykaempferol-3,6-Diglucoside in Normal and Diabetic Cardiomyopathy Mice.

6-Hydroxykaempferol-3,6-diglucoside is an important flavonoid constituent of Carthamus tinctorius L., with potential antioxidant and myocardial protective effects. However, its pharmacokinetic charact...

Neurogenic shock to the heart: a rare case of meningitis-triggered reverse takotsubo cardiomyopathy.

Reverse takotsubo cardiomyopathy, a rare variant of stress-induced cardiomyopathy, is characterized by basal hypokinesis with apical sparing and can be associated with neurological insults. Prompt rec...

Efficacy and safety of exercise for hypertrophic cardiomyopathy: a systematic review and meta-analysis.

BACKGROUND: Patients with hypertrophic cardiomyopathy (HCM) are generally restricted from exercising. We aimed to investigate the effects of exercise on cardiorespiratory fitness, cardiac structure, c...

Tissue-Resident Memory T Cells in the Heart: An Emerging Role in Chronic Inflammation.

T lymphocytes are increasingly recognized as central regulators of cardiac inflammation, contributing to both tissue repair and disease progression across conditions such as myocardial infarction, hea...

Fatal Myocarditis Caused by Canine Parvovirus in a Litter of One-Day-Old German Shepherd Puppies: Molecular and Histopathological Findings.

Canine parvovirus (CPV) is a highly contagious disease, typically causing haemorrhagic enteritis in dogs. The myocardial form, though well-documented historically, is now rare in vaccinated canine pop...

[Tako-Tsubo syndrome associated with acute carbamate poisoning in Tunisia: a rare, multifactorial cardiac complication].

INTRODUCTION: Poisoning by carbamate-type anticholinesterase insecticides can result in severe clinical symptoms involving the gastrointestinal, respiratory, and neurological systems. Here, we present...

Genomic Structural Equation Modeling Reveals Shared Genetic Architecture and Pleiotropic Hub Genes of Sepsis-Induced Cardiomyopathy.

Background: Sepsis-induced cardiomyopathy (SICM) is a life-threatening complication driven by inflammatory cascades. Current genetic studies are restricted to single-trait analyses that cannot capture...

Rippling muscle disease due to a CAV3 mutation with myocarditis-like presentation in an adolescent.

BACKGROUND: This case report describes a rare presentation of rippling muscle disease (RMD) due to a pathogenic CAV3 variant, manifesting with myocarditis-like cardiac involvement in an adolescent pat...

Autophagic therapeutic targeting for Doxorubicin-induced cardiomyopathy.

Autophagy has been extensively studied in a variety of pathologies, including neurological disorders, cancers, muscle diseases, aging, and cardiovascular diseases. Doxorubicin (Dox) is a potent antica...

Lupus myocarditis mimicking peripartum cardiomyopathy: A diagnostic challenge and successful clinical management.

Lupus myocarditis and peripartum cardiomyopathy can both present with acute heart failure symptoms during the peripartum period, leading to diagnostic uncertainty. Accurate and timely recognition of l...

In Silico Discovery of mTOR Inhibitors as Potential Therapeutics for Feline Hypertrophic Cardiomyopathy.

CONTEXT: Feline Hypertrophic Cardiomyopathy (HCM) is a significant health issue, with a current prevalence of 14.7% in cats. The mammalian target of rapamycin (mTOR) is an atypical serine/threonine pr...

Atypical manifestations of dengue in pediatric patients hospitalized during the 2023-2024 epidemic in Argentina: a multicenter registry.

UNLABELLED: We aimed to characterize encephalitis, myositis, and myocarditis, in hospitalized children during the 2023 - 2024 dengue epidemic in Argentina. This case series included patients younger t...

Suppression of Post-Ischemic Cardiac Remodelling and Inflammatory Response by a Novel Sphingolipid Modifier, CIN038.

In patients with myocardial infarction (MI), the level of sphingolipids, such as ceramide (Cer), is elevated and is associated with an increased risk of progression towards heart failure (HF). Dihydro...

Genetically predicted lower FLT3L levels increase the risk of hypertrophic cardiomyopathy partly mediated by phosphate: Evidence from a 2-step Mendelian randomization analysis.

We performed a 2-step Mendelian randomization (MR) study to investigate the associations of Fms-related tyrosine kinase 3 ligand (FLT3L) and phosphate levels with the risk of hypertrophic cardiomyopat...

Assessing Quality of Life in Genetic Cardiomyopathies: A Scoping Review.

Genetic cardiomyopathies (GCMs) are chronic heart muscle disorders requiring lifelong monitoring and treatment. Although quality of life (QoL) and health-related quality of life (HRQoL) are increasing...