The AGE-RAGE-DIAPH1 Axis in Type 2 Diabetes and Metabolic Dysfunction: From Carbonyl Stress to Diabetic Myocardial and Neuronal Injury.
Carbonyl stress, chronic inflammation, and progressive tissue injury accompany type 2 diabetes mellitus (T2DM) and obesity. Yet, the molecular systems that connect these processes with cardiac, vascul...
Prevalence and clinical characteristics of sleep apnea in hypertrophic cardiomyopathy: A meta-analysis.
OBJECTIVE: To investigate the prevalence and clinical characteristics of sleep apnea (SA) in patients with hypertrophic cardiomyopathy (HCM). METHODS: Eligible studies were screened and selected from ...
Cardiac imaging in Chagas cardiomyopathy for phenotypic characterisation and risk stratification.
Chagas disease, caused by Trypanosoma cruzi, remains one of the leading infectious causes of non-ischemic cardiomyopathy worldwide. Although an estimated 6-7 million individuals are chronically infect...
Validity testing of the novel European Society of Cardiology EURObservational Research Programme PPCM Registry score to predict left ventricular recovery in a cohort of Ugandan women with PPCM.
BACKGROUND: Recently under the European Society of Cardiology (ESC) EURObservational Research Programme (EORP) PPCM registry the first predictive score was derived. This study sought to test the valid...
Beyond Clozapine: Myocarditis and Cardiomyopathy Associated with Antipsychotic Medications-An Updated Narrative Review for Psychiatric Practice.
BACKGROUND: Antipsychotic medications are associated with increased cardiovascular morbidity and mortality in patients with serious mental illness (SMI). Clozapine-induced myocarditis and cardiomyopat...
Septic cardiomyopathy: a rare and life-threatening complication of small intestinal perforation: A case report.
RATIONALE: Septic cardiomyopathy (SCM) is a severe and often reversible complication of sepsis but carries a high mortality rate when it progresses to cardiogenic shock. Differentiating SCM from acute...
Integrative Transcriptomics and Machine Learning Identify Macrophage-Associated Biomarkers in Hypertrophic Cardiomyopathy.
Hypertrophic cardiomyopathy (HCM) is a common genetic heart disease, with macrophages playing a critical role in its pathological remodeling. Our study aims to investigate the molecular basis of HCM b...
Histopathological Assessment of Myocardial Ischemia-Reperfusion Injury Using Transformer-Based Artificial Intelligence: Model Comparison Study.
BACKGROUND: Myocardial ischemia-reperfusion injury (MIRI) poses diagnostic challenges due to complex histopathological changes. OBJECTIVE: This study aimed to develop an intelligent framework for eval...
Tocilizumab for severe immune checkpoint inhibitor myopathy-myocarditis: acute and long-term outcomes.
BACKGROUND: Immune checkpoint inhibitor (ICI)-myopathy-myocarditis is an immune-related adverse event, with high mortality despite first-line immunosuppression. Emerging data suggest upregulation of t...
SLC11A1 Drives Ferroptosis in Acute Myocardial Infarction Via Sp1-mediated Transcriptional Repression of GPX4.
Ferroptosis is a critical contributor to cardiomyocyte injury in acute myocardial infarction (AMI). This study aimed to identify key ferroptosis-associated genes and elucidate their roles in AMI. Tran...
Myocarditis in idiopathic inflammatory myopathies: serologic and clinical correlates in a single-center registry.
To characterize the clinical and serological correlates of cardiovascular magnetic resonance (CMR)-confirmed myocarditis in idiopathic inflammatory myopathies (IIM), evaluate the diagnostic performanc...
Artificial Intelligence-Derived Electrocardiogram Analysis for Identification of Carbon Monoxide-Induced Cardiomyopathy: A Retrospective Study.
Background and Objectives: The diagnostic accuracy of an artificial intelligence (AI)-derived initial 12-lead electrocardiogram (ECG) analysis was evaluated for early carbon monoxide-induced cardiomyo...
Olive Oil-Based Lipid Emulsion Ameliorates Immune Checkpoint Inhibitor-Induced Myocarditis via Inhibition of the NF-κB/NLRP3/IL-1β Pathway.
The present study aimed to investigate the therapeutic efficacy and underlying mechanism of olive oil-based lipid emulsions (OOLE) in mitigating immune checkpoint inhibitor (ICI)-induced myocarditis t...
[Reflections on the management of a case of neurogenic stress cardiomyopathy complicated by acute submassive pulmonary embolism].
Due to their unique pathophysiological states, neurocritical care patients are at a significantly increased risk of acute pulmonary embolism. Typical symptoms are frequently masked by neurological def...
[Inflammatory Heart Disease: The Role of Multimodality Cardiac Imaging in Myocarditis and Pericarditis].
Myocarditis and pericarditis represent a broad spectrum of inflammatory heart diseases and are important differential diagnoses in patients presenting with chest pain, heart failure, or arrhythmias. D...
[Multimodal imaging in cardiac amyloidosis and cardiac sarcoidosis].
Cardiac amyloidosis and cardiac sarcoidosis can be classified as infiltrative cardiomyopathies. Although the aetiology and underlying pathophysiology of these two conditions differ substantially, imag...
Comparing Outcomes of Heartmate 3 and Heart Transplantation in Older Children With Dilated Cardiomyopathy-Can Transplantation be Delayed or Avoided?
BACKGROUND: Children with end-stage dilated cardiomyopathy (DCM) usually undergo heart transplantation or a short-term bridge with a ventricular assist device. Heartmate 3 (HM3) may represent an appea...
A pilot qualitative study of patient understanding and perceptions of genetic counselors and cascade testing in the context of transthyretin cardiac amyloidosis.
Genetics-informed care is becoming increasingly important in the management of cardiomyopathy (CM). Despite current guidelines recommending genetic testing and counselors, these services are vastly un...
Adeno-Associated Virus Vector Mediated Gene Therapy: A Promising Approach to Transform Hypertrophic Cardiomyopathy Treatment.
Hypertrophic cardiomyopathy (HCM) is a genetically heterogeneous myocardial disease that usually arises from mutations in key sarcomeric proteins, particularly MYBPC3 and MYH7. Current pharmacological...
Hybrid Cardiac (68)Ga-FAPI-4 PET/MRI in Dilated Cardiomyopathy: A Feasibility and Pilot Study.
Background Cardiac gallium 68-labeled fibroblast activation protein inhibitor (FAPI)-4 (68Ga-FAPI-4) PET/MRI allows simultaneous assessment of cardiac tissue characteristics, function, and molecular r...