Tracing the pathogenic PLN p.(Arg14del) variant across the globe; more than just a local curiosity.

Studying the global distribution of the pathogenic variant c.40_42delAGA;p.(Arg14del) in the phospholamban (PLN) gene is highly important for raising awareness among healthcare providers and may help ...

Circulating β-Hydroxybutyrate in Glycemic Progression and Diabetic Cardiomyopathy: Adaptive Signal or Maladaptive Substrate?

Circulating ketone bodies (KBs), particularly β-hydroxybutyrate (β-HB), have emerged as metabolites with dual roles as both oxidative fuels and metabolic signaling molecules. Beyond serving as an alte...

Acute and Chronic Myocarditis in Men and Women.

PURPOSE OF REVIEW: Acute myocarditis (AM) shows sex-specific differences in prevalence, clinical phenotype, and outcomes. This review summarizes evidence from studies published between 2000 and 2026 r...

[The role and mechanism of transient receptor potential M2 channel-mediated calcium homeostasis imbalance in the development of diabetic cardiomyopathy].

糖尿病心肌病是糖尿病患者发生心力衰竭的重要原因，而细胞内钙稳态失衡是驱动心肌损伤与心室重构的核心病理环节。瞬时受体电位M2通道作为一类具有Ca²⁺非选择性通透性的阳离子通道，是连接氧化应激与代谢紊乱的关键调控分子。该文主要介绍瞬时受体电位M2通道在糖尿病心肌病钙稳态失衡中的作用及相关分子机制，明确该通道可能成为糖尿病心肌病的潜在治疗靶点，以期为糖尿病心肌病的防治提供新的思路与方向。.

[New progress in diagnosis and treatment of hypertrophic cardiomyopathy with left ventricular apical aneurysm].

肥厚型心肌病（HCM）合并左心室心尖部室壁瘤是HCM的重要亚型，多见于左心室中部梗阻的患者，易引发血栓栓塞、恶性心律失常、心力衰竭甚至心脏性猝死等不良事件，患者预后不佳。因此，对此类患者开展早期识别并及时采取干预和治疗，对延缓病情发展、改善临床预后具有重要意义。该文就HCM合并左心室心尖部室壁瘤的发生机制、诊断方法、预后评估及治疗策略等方面的研究进展进行综述，以期为该特殊亚型的临床诊疗与管理提供参...

[Incremental value of CMR for the 2025 appropriate use criteria of ICD implantation in sudden cardiac death risk stratification of dilated cardiomyopathy].

Objective: To evaluate the predictive value of the 2025 appropriate use criteria (AUV) for implantable cardioverter defibrillators (ICD) jointly issued by the American College of Cardiology/American H...

Mechanistic Role of Sestrin2 in Exercise-Mediated Cardioprotection Against Obesity-Related Cardiomyopathy.

Exercise is one of the safe and effective methods to improve obesity and its complications, but the mechanism has not been fully elucidated. Sestrin2 (SESN2) is a stress-induced protein that protects ...

[Lactate induces gastric mucosal injury by promoting M1 polarization of macrophages via the cardio-gastric axis].

OBJECTIVES: To investigate the role of lactate in myocardial ischemia-reperfusion (MIR)-induced gastric mucosal injury. METHODS: Thirty C57BL/6J mice were randomized into sham-operated group, MIR (45 ...

Tongmai Yangxin pills alleviate myocardial ischemia-reperfusion injury by enhancing mitochondrial function via activating the ERK signaling pathway.

BACKGROUND: To explore the mechanism of Tongmai yangxin pills (TMYX) for improving myocardial ischemia-reperfusion injury (MIRI) in rats. METHODS: In a SD rat model of MIRI, the therapeutic effects of...

Myocardial Injury in Rheumatic Diseases: Immune and Microcirculatory and Molecular Mechanisms of Cardiomyopathies.

Immune-mediated myocardial injury is an important yet underrecognized manifestation of systemic rheumatic diseases and represents a biologically heterogeneous process extending beyond traditional card...

Clinical spectrum, cardiac phenotypes, and outcomes of FHL1-related cardiomyopathies: a systematic review.

BACKGROUND: Mutations in the Four-and-a-Half LIM Domains 1 (FHL1) gene are increasingly recognized as a rare cause of inherited cardiomyopathies, often associated with skeletal myopathy and adverse ca...

Randomized Controlled Trial of Internet-Delivered Cognitive Behavioral Therapy After Myocardial Infarction With Nonobstructive Coronary Arteries or Takotsubo Syndrome.

BACKGROUND: Patients with myocardial infarction with nonobstructive coronary arteries (MINOCA) or Takotsubo syndrome (TS) often suffer from poor mental health and low quality-of-life post event, with ...

SGLT2 Inhibitors in Hypertrophic Cardiomyopathy: Emerging Evidence and Putative Mechanisms.

Hypertrophic cardiomyopathy (HCM) is the most common inherited myocardial disorder and a major cause of heart failure (HF) and sudden cardiac death. Although sarcomeric gene mutations initiate the dis...

[Advances in the molecular genetics of nuclear gene mutations causing pediatric mitochondrial cardiomyopathy].

Mitochondrial cardiomyopathy (MCM) is a heterogeneous group of disorders characterized by abnormal myocardial structure and/or function caused by defects in genes encoding the oxidative phosphorylatio...

[Early warning indicators and prognosis in children with fulminant myocarditis treated with extracorporeal membrane oxygenation].

OBJECTIVES: To explore early warning indicators for extracorporeal membrane oxygenation (ECMO) in children with fulminant myocarditis (FM) and their association with prognosis. METHODS: Clinical data ...

Zebrafish dspb-/- mutant as a model for non-dilated left ventricular cardiomyopathy: exploring cardiac dysfunction and exercise modulation.

Truncating variants in the DSP gene are associated with non-dilated left ventricular cardiomyopathy (ND-LVC), characterized by impaired ventricular function without dilation. The influence of physical...

FTO Regulates Autophagy and Energy Metabolism in Sepsis-Induced Cardiomyopathy: Insights From Integrated Transcriptome and Proteome Analysis.

Sepsis-induced cardiomyopathy (SCM) is a severe complication of sepsis, characterized by profound cardiac dysfunction and high mortality, but its molecular mechanisms remain poorly defined. RNA epigen...

Hydroxychloroquine-associated cardiomyopathy with nondiagnostic noninvasive evaluation: diagnostic value of endomyocardial biopsy in a case-based review.

Hydroxychloroquine (HCQ) is a cornerstone in treating autoimmune diseases and is generally well-tolerated. Cardiotoxicity is a rare but serious adverse effect of prolonged HCQ therapy. The progression...

Low-Level Domoic Acid Exposure Induces Age-like Cardiomyopathy in Young Adult and Aged Mice.

Domoic acid (DA) is a well-known seafood toxin produced by some species of marine phytoplankton in the genus Pseudo-nitzschia during harmful algal blooms (HABs). Acute toxic exposures induce overt cli...

Severe right heart failure following HeartMate 3 implantation in a small pediatric patient: a case report.

HeartMate 3 (HM3) has demonstrated excellent outcomes in adults, and its use in pediatric patients has recently increased. In small pediatric patients, previous studies have mainly focused on whether ...