Oral PCSK9 Inhibitor Enlicitide Versus Oral Nonstatin Therapies: A Phase 3 Randomized Clinical Trial.
Many adults fail to achieve guideline-directed low-density lipoprotein cholesterol (LDL-C) goals on statin monotherapy, requiring additional nonstatin lipid-lowering medication. Enlicitide, an oral pr...
Midlife Cardiorespiratory Fitness and Healthy Aging: An Observational Cohort Study.
Higher cardiorespiratory fitness (CRF) is associated with a lower risk for chronic disease and death, but its relation to healthy aging more broadly remains understudied. The aim of this study was to ...
How to Image Myocarditis.
Myocarditis is an inflammatory disease involving the heart muscle and potentially the pericardium. While there are many potential causative agents, commonly grouped into infectious (viral, bacterial, ...
Rare KDR Variants Define a Distinct Genetic Contribution to Congenital Heart Disease.
Monoclonal antibodies targeting IL-5/5R or IL-4/13 pathways in eosinophilic myocarditis: a single-center experience and systematic literature review.
Eosinophilic myocarditis (EM) is a rare inflammatory heart disease often associated with eosinophilic granulomatosis with polyangiitis or hypereosinophilic syndrome. While anti-IL-5/5R and anti-IL-4/1...
Transcatheter closure of a ruptured sinus of Valsalva aneurysm-a minimally invasive approach to a rare cardiac emergency: a case report.
Sinus of Valsalva aneurysm (SVA) is a rare but clinically significant cardiac anomaly, arising congenitally or through acquired causes. Typically, asymptomatic until rupture, this condition can precip...
Inflammation-related acute coronary thrombosis following vaccination: a case report.
Acute chest pain and troponin changes in middle-aged individuals can pose a diagnostic challenge, as age-related vascular changes may complicate common inflammatory and infectious conditions, affectin...
Endothelial decorin in cardiac ageing: mechanistic ambiguities and therapeutic challenges.
This letter provides a critical analysis of the recent study by Luxán et al. (Cardiovasc Res. 2025) on the role of non-glycanated decorin in cardiac ageing. While acknowledging the importance of their...
Single nucleus RNA sequencing and functional in vivo studies reveal TCF21 as a protective regulator in cardiac fibrosis.
Cardiac fibrosis remains a significant and currently untreatable contributor to mortality in chronic heart disease. This study aimed to comprehensively map cell-specific pathological changes in fibrot...
Bridging the mind-heart gap: depression in CVD clinical practice guidelines.
Large-scale identification of protein biomarkers and therapeutic targets in heart and brain disease.
Neurological complications frequently impact morbidity, mortality and quality of life in patients with cardiovascular disease, yet the biological mediators connecting cardiovascular and neurological d...
Stylet-Driven Versus Non-Stylet-Driven Leads for Conduction System Pacing: Insights from the NCDR EP Device Registry.
Conduction system pacing (CSP), including His bundle pacing (HBP) and left bundle branch area pacing (LBBAP), is a growing alternative to traditional right ventricular or biventricular pacing. The cho...
Clotting the Gap Between Mitochondria-Mediated Immunity and Mitochondrial Transfer.
Mitochondria are organelles that orchestrate numerous cell functions in addition to providing energy. During viral infection or in case of defects in mitochondrial replication, an intricate mechanism ...
Partial cor triatriatum sinistrum case series: is percutaneous balloon dilatation a promising alternative to surgery?
Partial cor triatriatum sinistrum is a rare congenital heart disease and is usually considered for surgery in symptomatic patients. We describe three cases of partial cor triatriatum sinistrum, two ca...
Case Report: Angiographic Remodeling of a Chronic Total Occlusion Four Years After Extraplaque Wiring: Implications for Procedural Reattempt.
An investment procedure during chronic total occlusion (CTO) percutaneous coronary intervention (PCI) involves intentional alteration of the proximal cap with the aim of facilitating subsequent CTO PC...
Severe polyarterial involvement in a 16-year-old with homozygous familial hypercholesterolaemia: a case report.
Homozygous familial hypercholesterolaemia (HoFH) is a rare genetic disorder characterized by an elevated plasma concentration of low-density lipoprotein cholesterol (LDL-C) starting at birth and a sig...
Electrophysiology in Adults With Congenital Heart Disease as an Area of Focused Competency.
Visual Acuity and Cardiovascular Mortality in 2.52 Million Older Adults in China.
Visual acuity (VA) impairment and cardiovascular disease (CVD) are major global health burdens. Although impaired VA is linked to elevated all-cause mortality risk, its association with CVD mortality,...
Rapid Genome Sequencing Shows Diagnostic Utility in Infants With Congenital Heart Defects.
Congenital heart disease (CHD) is the most common birth defect and a leading cause of infant mortality. CHD often has a genetic cause, and recent studies demonstrate the utility of genetic testing. In...
Response by Murchland et al to Letter Regarding Article, "Experiences of Stalking and Obtaining a Restraining Order Are Associated With Onset of Cardiovascular Events in Women: A Prospective Analysis in the Nurses' Health Study II".