Clinical Significance of the Hyperintense Reperfusion Marker and Ocular Gadolinium Leakage After Thrombectomy: A Retrospective ETIS Study.
BACKGROUND AND OBJECTIVES: Despite successful recanalization after mechanical thrombectomy for acute ischemic stroke, a substantial proportion of patients experience early neurologic deterioration or ...
ORAI Ca(2+) channels and STIM1 drive capillary-to-arteriole communication in neurovascular coupling.
Neurovascular coupling (NVC), which is initiated by the brain's dense capillary network, matches blood flow to neuronal activity. We found that ORAI1 channels and their regulator STIM1, the main drive...
A mechanistic evaluation of sodium channel modulators in hiPSC-derived cardiomyocytes using fluorescence-based sodium flux imaging.
Drug-induced cardiotoxicity remains a significant challenge in pharmaceutical development. While patch-clamp remains the gold standard for evaluating ion channel effects, its low throughput limits ear...
Axial Length-Associated Structural and Microvascular Retinal Changes in Myopia: A Combined OCT and OCTA Analysis.
PURPOSE: To evaluate associations between axial length (AL) and optical coherence tomography (OCT) and OCT angiography (OCTA) parameters, including vessel density (VD) in the superficial and deep macu...
Type I IFN signaling shapes subset-specific monocyte fates in the injured myocardium.
Monocytes and macrophages promote tissue repair following myocardial infarction, but the mechanisms tuning their effector functions remain elusive. While macrophages are essential in clearing debris a...
Fueling fibrosis: BCAT1 links branched-chain amino acid metabolism to collagen production.
Fibrosis remains a major driver of organ dysfunction, yet the metabolic programs that sustain extracellular matrix production are incompletely understood. In this issue of the JCI, Takizawa and collea...
Revising NHE-1: From Cardiac Homeostasis to Heart Failure and Future Drug Development.
NHE-1 is a Na+/H+ exchanger that receives phosphorylation signals, binds calmodulin and responds to neurohormonal input from angiotensin II, endothelin-1, and adrenergic pathways. In cardiac myocytes,...
Association of Transition Zone Burden With Recurrence in Elderly Patients With Paroxysmal Atrial Fibrillation Without Low-Voltage Areas.
BACKGROUND: Transition zone (TZ) may serve as a potential substrate for atrial fibrillation (AF). This study aims to investigate the relationship of TZ burden with left atrial conduction velocity (LAC...
Female vulnerability to microvascular transport dysfunction emerges early across the Alzheimer's disease continuum.
INTRODUCTION: We tested whether quantitative transport mapping (QTM)-derived perfusion velocity would detect earlier and more sex-specific microvascular alterations than cerebral blood flow (CBF) acro...
Integrative Cross-platform Analysis of Kinase Inhibitor Effects on Statin-relevant Cardioprotective Pathways in Human Cardiomyocytes.
BACKGROUND/AIM: Kinase inhibitors (KIs) can cause cardiotoxicity through mechanisms overlapping with statin cardioprotective pathways, yet their effects on these pathways in cardiomyocytes remain unce...
Femoral and Brachial Artery Cut-Down for Vascular Access in Interventional Procedures.
Femoral and brachial artery cut-downs are classic surgical methods for establishing vascular access in interventional procedures. Although largely replaced by less invasive percutaneous techniques and...
Protracted Intraventricular Infusion of Gemcitabine to Circumvent the Blood Brain Barrier.
BACKGROUND/AIM: Poor prognosis of brain tumors is partly related to the blood brain barrier (BBB) to hydrophilic anticancer drugs. Early studies demonstrated that intracranial injection of vital dyes ...
What Does the Photoplethysmography Add to Laser Doppler Flowmetry During the Brachial Artery Occlusion Test?
In this study, the difference in behavior of the raw photoplethysmography (PPG) signal and the laser Doppler flowmetry (LDF) signal reflecting hemodynamics in the skin of upper extremities at brachial...
Duration-Dependent Cardiac Effects of Anabolic-Androgenic Steroid Use in Strength-Trained Athletes: A Systematic Review and Meta-Analysis.
PURPOSE: Nonmedical anabolic-androgenic steroid (AAS) use is increasing, and its duration-dependent cardiac effects remain unclear. We evaluated cardiac structure and function in AAS-using strength-tr...
Feto-Maternal Microchimerism and the Brain: Mechanisms, Neurological Implications, and Translational Perspectives.
PROBLEM: Microchimerism in the brain is a common phenomenon, where in cells cross between mother and fetus during pregnancy, and persist for decades. It has been studied primarily within reproductive ...
Segmental Aplasia and Right Azygos Continuation of the Caudal Vena Cava in a Cat (Felis catus).
Segmental aplasia of the caudal vena cava is a rare variant, primarily reported in dogs. We describe herein a cat with this anomaly. The caudal vena cava was formed by confluence of the right and left...
Exacerbated expansive vascular remodeling due to disturbed flow in male mice overexpressing protein disulfide isomerase-A1.
Vascular expansive remodeling is involved in atherosclerosis/restenosis; however, its mechanisms need further investigation. Protein-disulfide isomerase (PDIA1), a redox chaperone from the endoplasmic...
Mueller manoeuvre increases the mitral-to-aortic velocity-time integral ratio, a mitral regurgitant index, in patients with dilated cardiomyopathy.
A reduction of intrathoracic pressure during the Mueller manoeuvre (MM) has been shown to decrease left ventricular (LV) forward stroke volume in patients with systolic heart failure. To assess the un...
The Impact of Overtraining on Anxiety-Like Behavior and Tight Junction Proteins of the Blood-Brain Barrier in Mice.
PURPOSE: Overtraining Syndrome (OTS) is a chronic maladaptive condition characterized by persistent performance decline due to excessive training and inadequate recovery. OTS is associated with mood d...
Safety and Efficacy of Pulsed-Field Ablation With a Pentaspline Ablation Catheter Versus Cryoablation for Atrial Fibrillation: A Systematic Review and Meta-Analysis.
BACKGROUND: Pulsed-field ablation (PFA) is an emerging technology for atrial fibrillation (AF) ablation. However, there is few studies comparing the clinical advantages and disadvantages of PFA and cr...