Empagliflozin Improves Endothelial Function in an Ovariectomized Rat Model of Estrogen Deficiency.

Cardiovascular disease risk increases after menopause, largely driven by estrogen deficiency-induced endothelial dysfunction. While sodium-glucose cotransporter 2 (SGLT2) inhibitors confer cardiovascu...

Extensive venous thromboembolism secondary to uterine fibroid compression of the inferior vena cava.

A woman in her 40s presented with a 2-day history of progressive left lower limb swelling and dyspnoea. She had a background of heavy menstrual bleeding and previously underwent insertion of an intrau...

Paediatric midaortic syndrome associated with ascending aortic and renal aneurysm managed with complex multidisciplinary medical management and surgical repair.

We present the case of an otherwise previously healthy female in middle childhood with severe renovascular hypertension secondary to midaortic syndrome with ascending aortic dilation. She presented wi...

"Heart-in-the-dish" models identify mechanisms of diastolic dysfunction.

Modeling of cardiac pathologies in tissue-engineered models is coming of age. Two independent studies by Reid et al.1 and Tani et al.2 present in-depth multi-phenomics data from a human cardiac organo...

FUNDC1-mediated mitochondrial quality control protects against immune checkpoint inhibitor-associated cardiac injury.

Immune checkpoint inhibitors (ICIs) targeting PD-1 are effective cancer therapies but can cause severe myocarditis. The molecular mechanisms linking PD-1 blockade to cardiomyocyte damage are incomplet...

Unexpected doornail hilar lymph nodes during robot-assisted pulmonary resection: intraoperative challenges and management strategies.

Hilar lymph nodes with dense adhesion to the bronchus and pulmonary artery ("doornail" nodes) can be encountered unexpectedly during robot-assisted pulmonary resection. We report our experience managi...

DTI-ALPS is not independently associated with overall survival beyond established prognostic factors in glioblastoma.

PURPOSE: Impaired glymphatic function has been associated with shorter survival in glioblastoma. However, the relationship between glymphatic dysfunction and survival has not yet been evaluated in the...

Granulomatous amoebic encephalitis: pathogenesis, diagnostic advances, therapeutic challenges, and emerging treatment strategies.

Granulomatous amoebic encephalitis (GAE) is a rare but highly fatal central nervous system infection caused primarily by Acanthamoeba spp. and Balamuthia mandrillaris. Delayed diagnosis and the absenc...

Role of the TLR4-NF-κB-FDX1 cuproptosis axis in mediating cognitive impairment associated with type 1 diabetes in children: an exploratory mechanistic study.

This study explored how the TLR4-NF-κB-FDX1 cuproptosis axis contributes to type 1 diabetes (T1DM)-related cognitive impairment, seeking to uncover novel intervention targets. Key genes were screened ...

Sphingolipids and Atherosclerosis.

PURPOSE OF REVIEW: We integrate evidences from human and mouse model studies which emphasize sphingolipid metabolism-mediated endothelium-lipoprotein-atherogenic plaque framework. The review may provi...

Endoscopic mitral valve replacement in extensive mitral annular calcification with a posterior pericardial patch.

Extensive mitral annular calcification represents a major technical challenge in mitral valve surgery and is associated with increased operative mortality and morbidity, including atrioventricular dis...

Aortic valve repair after atrial switch operation with autologous pulmonary artery wall.

Neoaortic valve repair after arterial switch operation can be challenging due to altered valve geometry and the absence of an ideal material for leaflet augmentation. We report repair of severe neoaor...

Short-term risk of recurrent stroke in symptomatic carotid near-occlusion: pooled analysis of three cohort studies.

INTRODUCTION: Carotid near-occlusion (CNO) is a severe carotid stenosis causing distal internal carotid artery (ICA) diameter reduction, classifiable as with or without full collapse. Whether full col...

Molecular mechanisms, therapeutic strategies, and inter-organ fibrosis crosstalk of Gla proteins in cardiovascular disease.

Gla proteins are a vitamin K-dependent family long studied for their roles in blood clotting and vascular calcification. This review examines their broader involvement in cardiovascular disease, parti...

Model-Assisted Prioritization of Gelatin Methacryloyl (GelMA) Hydrogel Formulations for Three-Dimensional Cell Culture.

Owing to highly tunable mechanics, gelatin methacryloyl (GelMA) hydrogels are widely exploited for three-dimensional (3D) cell culture, whereas limited experimental sampling restricts efficient formul...

Zafirlukast Exacerbates Behavioral Seizure Activity and Blood-Brain Barrier Disruption Despite Modestly Reducing Neuronal Injury Markers in a PTZ-Induced Early Epileptogenesis Mouse Model.

Epilepsy is one of the most prevalent neurological disorders worldwide, and approximately 25% of patients remain refractory to pharmacological treatment. Blood-brain barrier (BBB) disruption and react...

GPR146 Deficiency Enhances Microglial Phagocytosis and Blood-Brain Barrier-Associated Markers in an Acute Amyloid-β Model.

Dysregulation of brain cholesterol homeostasis is increasingly recognized as a critical driver of Alzheimer's disease (AD) pathogenesis. G protein-coupled receptor 146 (GPR146) has emerged as a pivota...

Chest Pain Due to Anomalous Origin of the Left Circumflex Artery From the Opposite Sinus of Valsalva in a 70-Year-Old Woman.

BACKGROUND An anomalous origin of a coronary artery from the opposite sinus of Valsalva (ACAOS) is a rare congenital coronary abnormality that is usually asymptomatic throughout life. However, an anom...

The glymphatic system and Parkinson's disease: a narrative review.

BACKGROUND: The glymphatic system, a glia-dependent perivascular fluid transport pathway, has provided new insights into brain homeostasis and neurodegeneration. Although Parkinson's disease (PD) is c...

A Double-Vessel Coronary Artery Bypass Grafting Porcine Model using Autologous Internal Mammary Veins.

The saphenous vein is one of the most commonly used conduits in coronary artery bypass grafting (CABG). However, the high long-term failure rate limits its clinical efficacy. Although hemodynamic fact...