MicroRNA-223-3p/NLRP3 axis attenuates LPS-induced sepsis-like myocardial dysfunction by suppressing cardiomyocyte pyroptosis.

BACKGROUND: Sepsis-induced cardiomyopathy (SIC), a life-threatening complication of sepsis that is characterized by myocardial inflammation and cardiomyocyte death, remains a critical clinical challen...

Spatiotemporal Strategies for Lipid-Based Nanocarriers in Stroke.

Stroke remains a leading global health problem, and effective neuroprotective and regenerative therapies are still limited. Although acute-phase reperfusion strategies have advanced, their narrow ther...

Quadricuspid truncal valve repair in a 6-year-old with severe annular dilatation.

Reintervention after truncus arteriosus repair is frequently driven by progressive neoaortic (truncal) valve regurgitation. In many patients, valve dysfunction is primarily associated with annular and...

Drug-eluting balloon angioplasty versus uncoated balloon angioplasty for peripheral arterial disease of the lower limbs.

BACKGROUND: Atherosclerotic peripheral arterial disease (PAD) can lead to chronic limb-threatening ischemia (CLTI) and limb loss. Treatments include lifestyle modifications, medications, and both open...

Investigating Retinal Microvascular Changes Using OCT-Angiography: The Role of Oxidative Stress and Endothelial Dysfunction in Hypertensive Nephropathy.

Background and Objectives: Arterial hypertension is a major cause of systemic microvascular damage involving target organs such as the kidneys and retina. Because the retinal and renal microcirculatio...

Serial dual-wavelength illumination for retinal vessel oximetry using a conventional fundus camera: a proof-of-concept study.

PURPOSE: Retinal vessel oximetry requires fundus images at two wavelengths with different hemoglobin absorption characteristics. Simultaneous acquisition using one-chip color cameras may be affected b...

The Protective Effects of Chlorogenic Acid in Mitigating Gut-Brain Barrier Dysfunction and Autism-Like Symptoms Caused by Early-Life Stress in Mice: A Behavioral, Histopathological, and Molecular Study.

Autism spectrum disorder (ASD) is a multifactorial neurodevelopmental condition shaped by both genetic predispositions and environmental influences. Early-life stresses (ELS), notably maternal separat...

Salidroside Alleviates Mobocertinib-Induced Cardiotoxicity by Improving Cardiac Electrophysiology.

Mobocertinib, a tyrosine kinase inhibitor approved for EGFR exon 20 insertion-mutated non-small cell lung cancer, induces cardiotoxicity manifesting as QT prolongation. Salidroside, a bioactive compou...

Natural Products Targeting Myocardial Fibrosis: Pharmacological Basis, Molecular Mechanisms and Translational Barriers.

Myocardial fibrosis (MF) is a hallmark of pathological cardiac remodeling, driven by extracellular matrix (ECM) accumulation, fibroblast activation, and oxidative stress. Diverse natural products-nota...

Left Ventricular Longitudinal Strain Is Associated with Ascending Aortic Diameters in Healthy Adults-A Detailed Single-Center Retrospective Analysis from the Three-Dimensional Speckle-Tracking Echocardiographic MAGYAR-Healthy Study.

Background and Objectives: A more precise understanding of ventriculo-arterial coupling is essential, particularly regarding quantitative and qualitative associations can be demonstrated between the a...

Quantifying the impact of coronary-related experimental simplifications on flow features in native and neo-sinus following transcatheter aortic valve implantation.

Existing in vitro and numerical studies lack consensus regarding whether and how coronary arteries should be incorporated. This study aims to systematically investigate the effects of coronary artery ...

GPR75 mediates hyperuricemia-induced endothelial inflammatory injury via a HOTAIR/miR-141-3p regulatory network.

BACKGROUND: Hyperuricemia-related vascular endothelial injury is closely associated with hypertension, atherosclerosis, and other cardiovascular diseases. Although GPR75 has been implicated in vascula...

Temperature dependence of activation of thick and thin filaments in skeletal and cardiac muscles.

Contraction of striated muscle is initiated by an increase in the cytosolic Ca2+ concentration, which is regulated by tropomyosin and troponin on thin filaments in sarcomeres; viz., the binding of Ca2...

Morphoanatomical radiological analysis of pulmonary venous drainage patterns and left atrial morphology based on CT angiography.

PURPOSE: This study aimed to characterize the pulmonary venous (PV) drainage patterns and left atrial (LA) morphologies, and to perform a detailed morphoanatomic analysis based on computed tomography ...

Risk assessment and outcomes of systolic anterior motion in robotically assisted mitral valve repair.

Systolic anterior motion (SAM) is a known complication of mitral valve repair characterized by displacement of the anterior leaflet to the left ventricle outflow tract (LVOT) during systole leading to...

Exercise Preconditioning Activates AMPK-ACC Signaling and Attenuates Myocardial Ischemia/Reperfusion-Induced Ferroptosis.

Ferroptosis critically mediates myocardial ischemia/reperfusion (I/R) injury. Exercise training confers cardioprotection, but whether it protects against I/R-induced ferroptosis and the underlying mec...

Analysis of serum NMR metabolomics in fibrotic diseases of the myocardium.

INTRODUCTION: Heart failure accounts for more than 43% of annual deaths worldwide, and isdriven by widespread pathological remodeling, in which myocardial fibrosis plays an important role. Currently, ...

Accessory posterior cerebral artery-posterior cerebral artery anastomosis located just distal to the P1-P2 junction incidentally diagnosed by magnetic resonance angiography.

PURPOSE: To describe a case of an accessory posterior cerebral artery (PCA)-PCA anastomosis located just distal to the P1-P2 junction. METHODS: A 73-year-old man underwent cranial magnetic resonance (...

Carotid Free-Floating Thrombus: A Case Series, Narrative Review, and Proposal for Biology-Guided Treatment Selection.

Background: Carotid free-floating thrombus (CFFT) is an uncommon but clinically significant cause of transient ischemic attack and ischemic stroke, carrying a substantial risk of recurrent cerebral em...

Metabolic fatty acid substrates enhance the structural and mechanical performance of human-induced pluripotent stem cell-derived cardiomyocytes.

Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) offer a powerful platform for disease modeling, drug discovery, and regenerative therapies. However, their clinical and research ...