Neochordae for robotic repair of posterior leaflet prolapse.

Resectional and non-resectional techniques are both well established in mitral valve repair. While we generally prefer resectional methods when feasible, neochordae represent an essential complementar...

Membranous Interventricular Septal Aneurysm (MVSA) as a rare potential cause of embolic stroke: a case report and literature review.

INTRODUCTION: Membranous interventricular septum aneurysm is an infrequent source of cardioembolic stroke with only a few cases reported to date. METHODS: We present a case of recurrent ischaemic stro...

Learning from Biodegradable Coronary Stents: Future Directions for TPVR Biodegradable Stents.

Bioresorbable stents (BRS) have been explored in cardiovascular intervention to provide temporary mechanical support while reducing long-term foreign material. The coronary experience has shown both t...

Theranostic Innovative Strategies for Brain Diseases: New Insights on Neurovascular Unit-Associated Pathological Changes in Neurodegenerative Disorders and Aging.

Central nervous system (CNS) disorders represent a significant healthcare challenge, with aging as the primary risk factor. Current clinical management remains predominantly symptomatic, as late-stage...

Human Induced Pluripotent Stem Cell-Derived Cardioids as a Model to Assess Oligonucleotide Delivery.

Oligonucleotide-based therapeutics represent a rapidly advancing class of drugs with significant potential for treating cardiovascular diseases; however, achieving efficient delivery to cardiac tissue...

Impact of a durable left ventricular assist device on inflammation and cardiac remodelling in subjects with advanced heart failure.

BACKGROUND: This study aimed to explore the association of long-term left ventricular assist device (LVAD) support with changes in inflammation and cardiac remodelling in subjects with advanced heart ...

In-hospital cardiopulmonary resuscitation with balloon occlusion of the descending aorta: protocol of the randomised controlled CPReboa study.

INTRODUCTION: Cardiac arrest (CA) remains a major health burden with poor survival and poor neurological outcomes despite decades of advances in resuscitation science. Although high-quality cardiopulm...

Adenosine Triphosphate Nanoparticles with Blood-Brain Barrier Permeability for Prevention of Cerebral Ischemic Injury via Mitochondrial Homeostasis.

Cerebral ischemia induces selective neuronal death, largely due to mitochondrial dysfunction and ATP depletion. This energy crisis impairs mitophagy, exacerbates oxidative stress, and accelerates neur...

Astrocyte-Microglia Crosstalk in Post-Hemorrhagic Neurovascular Microenvironment: Mechanistic Nodes, Cross-Stroke Comparisons, and Therapeutic Reprogramming.

BACKGROUND: Intracerebral hemorrhage (ICH) produces a rapidly evolving and spatially heterogeneous neurovascular microenvironment in which secondary injury is shaped not only by hematoma volume and lo...

BHT and Its Metabolites Disrupt β2-Adrenergic Signaling: A Biotransformation-Dependent Cardiotoxicity Mechanism in Zebrafish.

Butylated hydroxytoluene (BHT) is a widely used synthetic phenolic antioxidant, ubiquitously detected in aquatic environments. While traditionally considered safe based on in vitro data, BHT adversely...

Celiac Disease and the Nervous System: A Comprehensive Overview of Neurological Manifestations and Underlying Mechanisms.

Celiac disease (CD) is a chronic immune-mediated enteropathy triggered by gluten ingestion in genetically susceptible individuals. While traditionally associated with gastrointestinal (GI) symptoms, C...

Umbilical venous catheter tip position and risk of portal vein thrombosis in neonates: a retrospective cohort study.

PURPOSE: Umbilical vein catheterization (UVC) is widely used for vascular access in sick, especially preterm neonates. However, UVC placement is associated with an increased risk of portal vein thromb...

A reference protein atlas of the adult mouse brain vasculature.

Current methods for assessing low-abundance proteins in individual cells are limited. As a result, cell functions are often inferred from single-cell RNA sequencing (scRNA-seq) data, which can be misl...

From aging biology to cardiac biotechnology: emerging platforms for modeling cardiac aging.

Aging is a major contributor to cardiovascular disease and mortality in older adults. Yet most preclinical and experimental cardiac studies fail to account for age as a primary biological variable, le...

Noninvasive assessment of fetal metabolic acidemia by automated analysis of cardiac function using color tissue Doppler imaging in a sheep model.

Reliable noninvasive methods for accurately diagnosing fetal metabolic acidemia are still lacking. Our aim was to evaluate an ultrasound-based noninvasive method for assessing metabolic acidemia by an...

Prognostic Impact of Definite and Marginal Discordance Between Fractional Flow Reserve and Nonhyperemic Pressure Ratio.

BACKGROUND: Fractional flow reserve (FFR) and nonhyperemic pressure ratios (NHPR) can show either marginal or definite discordance. OBJECTIVES: This study sought to investigate the clinical significan...

Clinical Outcomes of Transfemoral Transcatheter Mitral Valve Replacement: Results From the CHOICE-MI Registry.

BACKGROUND: Transcatheter mitral valve replacement (TMVR) is an alternative for patients with mitral regurgitation (MR), but data on transfemoral (TF) devices are limited. OBJECTIVES: The aim of this ...

VExUS Score and Hepatorenal Congestion Improvements After Transcatheter Tricuspid Intervention: Clinical and Prognostic Insights.

BACKGROUND: Severe tricuspid regurgitation (TR) is associated with morbidity and mortality and linked to intravascular venous congestion. Venous ultrasound of the hepatic, portal, and intrarenal veins...

Nicotinamide Mononucleotide Ameliorates Myocardial Fibrosis in Diabetic Mice Possibly by Modulating SIRT3 to Deacetylate GSK3β and Thereby Reducing the Phosphorylation of Smad3.

This study aims to investigate the therapeutic potential of NMN in alleviating type 2 diabetes-induced myocardial fibrosis.The experiment was comprised of control group, diabetic group, DM + NMN inter...

Prostatic Artery Embolization: A Contemporary Review of Efficacy, Safety, and Expanding Clinical Indications.

PURPOSE OF REVIEW: Prostatic artery embolization (PAE) has emerged as a minimally invasive treatment for a spectrum of prostatic conditions. Supported by a growing body of randomized and observational...