Optogenetic tachypacing facilitates burst-induced arrhythmia in stem cell-derived human atrial engineered heart tissue.

AIMS: Large animal models for atrial fibrillation (AF) research are ethically challenging and costly. Suitable humanized in vitro models could circumvent these problems. Here, we aimed to combine tiss...

MiR-221-5p aggravates sepsis-induced myocardial injury by targeting neuropilin-1.

Sepsis-induced cardiac dysfunction is a primary contributor to mortality, and microRNAs (miRNAs) are recognized as crucial mediators in sepsis pathogenesis. This study aims to identify the key regulat...

Coronary Calcified Nodules: From Pathological Definitions to Intravascular Imaging- and Morphology-Guided PCI.

Coronary artery calcification (CAC) is a hallmark of advanced atherosclerosis and a major determinant of procedural complexity during percutaneous coronary intervention (PCI). Once considered a passiv...

Conduction system pacing vs. biventricular pacing for cardiac resynchronization therapy in heart failure: a systematic review and meta-analysis considering randomized controlled trials and observational studies.

AIMS: Biventricular pacing (BiVP) is the gold standard for cardiac resynchronization therapy (CRT) in heart failure with reduced ejection fraction (HFrEF), yet up to 30% of patients fail to respond. C...

Conduction system vs. biventricular pacing in heart failure with reduced ejection fraction: a meta-analysis of randomized controlled trials.

AIMS: Conduction system pacing (CSP) has emerged as a physiologic alternative to cardiac resynchronization therapy (CRT) with biventricular pacing (BiVP) in heart failure with reduced ejection fractio...

High-riding brachiocephalic artery presenting as a pulsatile anterior neck mass.

Anterior neck swellings are commonly due to an enlarged thyroid gland, thyroglossal cyst or lymphadenopathy. Vascular causes are unusual and have a prevalence of about 4.5%.Herein, we present the case...

Right Ventricular Metastasis From Cervical Cancer Treated With Pembrolizumab-Containing Chemotherapy: A Case Report and Literature Review.

BACKGROUND Cardiac metastasis from cervical cancer is extremely rare and associated with a poor prognosis. Given its rarity and the critical anatomical location of the lesion, optimal treatment strate...

Kaempferol-Conjugated Manganese Oxide Nanocomposites Mitigate Aluminium Chloride-Induced Neurobehavioral Impairments in a Rat Model of Alzheimer's disease.

The neurodegenerative illness Alzheimer's disease (AD) causes cognitive decline. The production of oxidative stress in neurons is thought to play a role in the emergence of AD. The antioxidants, inclu...

Relation of nailfold capillaries and autoantibodies to mortality in patients with Raynaud's phenomenon: a retrospective analysis.

The presence of abnormal nailfold capillaries and antinuclear antibodies (ANA) is associated with increased all-cause mortality in patients presenting with incipient Raynaud's phenomenon (RP). We cond...

The Anatomical Landscape of Living Donor Livers: A 101-Case Retrospective Single-Center Study in Indonesia From 2010 to 2025.

BACKGROUND Anatomical variations of the hepatic vasculature and bile ducts are critical considerations in living donor liver transplantation (LDLT), yet population-specific data remain limited. This r...

Nonconjugated Alkyl Chains in Ionic Molecular Rotor Fluorophores: An Effective Modulating Moiety for Amyloid-β Probes.

Developing molecular structural tuning strategies for ionic molecular rotor (MR)-based β-amyloid (Aβ) fluorescent probes is essential for balancing high sensitivity, signal-to-background ratio (SBR) i...

Heart failure with reduced ejection fraction (HFrEF) is characterized by impaired contractility and high mortality. Dysregulation of intracellular ion (ie, Na

Subtype-Specific Macular Microvascular Changes in Accommodative Esotropia Assessed by Optical Coherence Tomography Angiography.

PURPOSE: The purpose of this study was to evaluate macular microvascular alterations in children with accommodative esotropia (AE) using optical coherence tomography angiography (OCTA) and to determin...

Morphometric Analysis of Retinal Vessels Using High-Resolution OCT Technology in Healthy Subjects.

PURPOSE: To assess the performance of a novel high-resolution optical coherence tomography (High-Res OCT) research platform with 3-µm axial resolution in measuring retinal vascular metrics in healthy ...

Maternal Health Outcomes in Nepalese Women After Mitral Valve Replacement.

BACKGROUND: The effects of anticoagulation on maternal health in patients with prosthetic valves remain understudied. Our study aims to assess maternal health post-mitral valve replacement (MVR), preg...

Restrictive Left Ventricle-to-Pulmonary Artery Conduit as an Alternative Biventricular Strategy in Complex Congenitally Corrected Transposition of the Great Arteries.

OBJECTIVES: Biventricular repair of congenitally corrected transposition of the great arteries (ccTGA) with a nonrestrictive ventricular septal defect (VSD) and left ventricular outflow tract obstruct...

Dynamic and Structural Retinal Microvascular Alterations After Radiation Exposure: Insights From a Large-Animal Model.

PURPOSE: To investigate the effects of acute radiation exposure on retinal microvascular health using the New Zealand White Rabbit (NZWR) model, aiming to enhance understanding of vascular response to...

Panoramic Near-Infrared Imaging Device for Peripheral Vascular Mapping.

Longitudinal mapping of the superficial peripheral vascular network is clinically relevant for conditions such as venous insufficiency, superficial venous thrombosis, and localized hemorrhagic injury;...

SDA-SwinNet: Swin-UNet with Dense Skip and Shift-ASPP for Retinal Vessel Segmentation.

Retinal artery/vein segmentation is a prerequisite for many ophthalmic diagnostic tools. Yet, the task remains difficult: vessels form complex trees, vary widely in caliber, and often appear low-contr...

A Heterogeneous Codonopsis pilosula Polysaccharide Preparation Attenuates Doxorubicin-Induced Cardiotoxicity in Mice: Associations with Oxidative Stress, Mitochondrial Function, and Gut Microbiota.

Doxorubicin-induced cardiotoxicity remains a major limitation of anthracycline chemotherapy and is closely associated with oxidative stress and mitochondrial dysfunction. Here, we investigated whether...