ATP6AP2 ameliorates inflammation and pyroptosis in heart failure by promoting lysosome-dependent STING degradation.

Inflammatory activation is involved in the pathogenesis of heart failure (HF). ATPase H+-Transporting Accessory Protein 2 (ATP6AP2) is an auxiliary subunit of the V-ATPase, and its role in HF is not f...

Development of a histological grading system for assessing microplastic-induced structural damage in rat aorta, trachea, and bladder tissues following acute exposure.

INTRODUCTION: Microplastic (MP) exposure has increasingly been associated with tissue-level impact in toxicology studies, including inflammatory changes and histopathological injury in aquatic and mam...

Multivariate adaptive regression spline modeling for estimating carotid artery plaque thickness in Chinese men with type 2 diabetes.

ObjectiveThe incidence of type 2 diabetes continues to increase worldwide, with cardiovascular disease as the leading cause of mortality in this population. Carotid artery plaque thickness serves as a...

First-Pass Perfusion and T1-weighted Dixon Imaging as Emerging Biomarkers of Pericardial Disease.

Pericardial assessment with cardiac MRI relies on three complementary pillars: anatomic evaluation, functional characterization, and tissue characterization. Tissue characterization traditionally depe...

Optimal Duration of Dual Antiplatelet Therapy After Percutaneous Coronary Intervention of the Left Main Coronary Artery: A Contemporary Narrative Review.

Background: The optimal duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) of the left main coronary artery remains uncertain because this lesion involves a la...

Indoxyl Sulfate-Mediated Blood-Brain Barrier Damage in Chronic Kidney Disease.

Chronic kidney disease is associated with neurovascular complications including cognitive impairment, potentially involving blood-brain barrier (BBB) impairment. The protein-bound uremic toxin indoxyl...

T1R3 Anchors ACE2 at the Pulmonary Endothelial Cell Surface to Attenuate Vascular Injury Following SARS-CoV-2 Spike 1 Protein Exposure In Vitro.

The development of acute lung injury in COVID-19 patients is a major cause of lethality. Activation of the pulmonary vasculature, with inflammation, oxidative stress and barrier disruption, is initiat...

eNOS Uncoupling, Shear-Stress Tolerance, and the Two-Threshold Model of Post-Exertional Malaise in Long COVID: A Mechanistic Hypothesis With Implications for Physiotherapy and Recovery Protocols.

OBJECTIVE: To propose and make testable a mechanistic hypothesis for post-exertional malaise (PEM) in a clinically distinct subset of Long COVID patients, in whom delayed exertional symptoms coexist w...

Shear-Wave Elastography, Superb Microvascular Imaging, and B-mode US for Diagnostic Accuracy in Soft Tissue Tumors.

Background Differentiating benign from malignant soft tissue tumors (STTs) remains challenging, and conventional US alone is often insufficient. This study evaluated whether elastography and microvasc...

Mechanism of Yangxin Dawa Yimixike Mi Gao for myocardial ischemia/reperfusion injury: an integrative study of network pharmacology and and validation.

OBJECTIVE: To systematically elucidate the cardioprotective mechanisms of the traditional Uyghur polyherbal formulation Yangxin Dawa Yimixike Mi Gao (YXDW, ) against myocardial ischemia/ reperfusion i...

Therapeutic effect of Fuzheng Yixin decoction on cardiac insufficiencythe soluble guanylyl cyclase-cyclic guanosine monophosphate-protein kinase G pathway in a doxorubicin-induced dilated cardiomyopathy rat model.

OBJECTIVE: To investigate the effect of Fuzheng Yixin decoction (, FZYX) and explore its underlying mechanisms in doxorubicin-induced dilated cardiomyopathy (DCM) rat model. METHODS: Sprague-Dawley ra...

Paeonol's protective effects on H9C2 cells against hypoxia/ reoxygenation injury through the hypoxia-inducible factor 1-alpha/B-cell lymphoma-2/adenovirus E1B 19 kDa interacting protein 3 signaling pathway.

OBJECTIVE: To elucidate the cytoprotective capacity of paeonol (PAE) against hypoxia/reoxygenation (H/R) injury in H9C2 cardiomyoblasts and to clarify its regulatory effects on the hypoxia-inducible f...

Retinal microvascular alterations and glymphatic dysfunction mediate the association between APOE ε4 and cognitive decline in Alzheimer's disease.

BACKGROUND: Vascular and glymphatic dysfunction are increasingly implicated in Alzheimer's disease (AD), particularly among apolipoprotein E (APOE) ε4 carriers. We investigated relationships among ret...

Longitudinal Patterns of Brain Parenchymal Damage Associated With the ALPS Index in a Community-Based Cohort.

AIMS: To better comprehend relationships between the analysis along the perivascular space (ALPS) index and glymphatic dysfunction, we assessed the spatiotemporal patterns of structural brain injury r...

[Compression Syndromes: New Insights into the Arterial Thoracic Outlet Syndrome].

The arterial Thoracic Outlet Syndrome (aTOS) is a rare condition affecting approximately 4 per 100000 individuals per year, predominantly young and active patients. It results from compression of the ...

Enhanced Pain Management With Combined EMLA Patch and Local Anesthetic Infiltration in Transradial Angiography.

BACKGROUND/OBJECTIVES: Pain at the radial access site remains common during coronary angiography. Evidence on topical anesthesia with EMLA patches is inconsistent, and the added value of combining EML...

Association of circulating miR-29b with microvascular dysfunction and digital ulcers in patients with systemic sclerosis: a single-centre pilot study.

OBJECTIVES: Systemic sclerosis is a rare autoimmune disorder marked by vasculopathy, immune dysregulation, and progressive fibrosis. Digital ulcers (DUs) reflect severe microvascular dysfunction. This...

[A novel extraction method and identification of primary mouse pulmonary artery smooth muscle cells].

Objective To establish an efficient and rapid primary culture protocol for mouse pulmonary artery smooth muscle cell (PASMC). Methods PASMC were isolated from mice using a novel dual-enzyme digestion ...

[PTPRO inhibitor alleviates cytoskeletal rearrangement and pyroptosis in brain microvascular endothelial cells in sepsis-associated encephalopathy via PI3K/AKT-related signaling].

Objective Sepsis-associated encephalopathy (SAE) is a common and severe complication of sepsis and is closely associated with blood-brain barrier (BBB) dysfunction and brain microvascular endothelial ...

Mechanisms of Acupuncture on the Neurovascular Unit in Migraine: A Narrative Review.

OBJECTIVE: The neurovascular unit (NVU) is a core structural and functional entity involved in migraine pathogenesis. Acupuncture may exert therapeutic effects by protecting NVU integrity. This narrat...