Multimodality Imaging of Unrepaired Adult Interrupted Aortic Arch With Pulmonary Artery Aneurysm.

A 25-year-old woman with progressive dyspnea underwent multimodality cardiovascular imaging, establishing the diagnosis of interrupted aortic arch with a giant pulmonary artery aneurysm. The combined ...

TRF2 Recovers Ischemic Postconditioning Cardioprotection in Aged Myocardiocytes by Regulating CSNK2A2 Localization and FUNDC1 Dephosphorylation.

Ischemic postconditioning (I/Post), which is an effective intervention by activating endogenous cardioprotective pathways, recovers ischemia/reperfusion injury. However, this intervention is not as ef...

Ambulatory Blood Pressure Characteristics and Target Organ Effects in Hypertensive Children With Renal Artery Variations.

Renal artery variations are recognized as potential contributors to hypertension through altered renal perfusion and activation of renin-angiotensin system. However, their clinical and hemodynamic sig...

Clinical Risk Assessment of Acute Intermediate-Risk Pulmonary Embolism Using Repeat Transthoracic Echocardiography.

BACKGROUND: Current risk stratification algorithms for intermediate-risk pulmonary embolism (PE) inadequately identify patients who may benefit from escalated care interventions (ECIs) beyond anticoag...

The impact of gestational diabetes mellitus on mid-pregnancy and infant cardiac morphology and function: A prospective cohort study.

ObjectiveTo evaluate the effects of gestational diabetes mellitus on cardiac morphology and function in fetuses during mid-pregnancy and in infants during the postnatal period.MethodsThis prospective ...

Regional astrocyte dysregulation and altered glymphatic-related markers in Alzheimer's disease frontal cortex.

INTRODUCTION: Astrocyte dysfunction is central to Alzheimer's disease (AD), yet expression patterns of astrocytic markers remain poorly defined. We measured Aquaporin-4 (AQP4) and glial fibrillary aci...

METTL14 Promotes Cuproptosis-Associated Changes in Rats With Myocardial Ischemia-Reperfusion Injury.

To investigate the role and mechanism of METTL14-mediated regulation of cuproptosis in myocardial ischemia-reperfusion injury (MI/RI). An MI/RI rat model was established. H9C2 cells were cultured and ...

Contemporary Management of Aortic Stenosis: Timing of Intervention and Lifetime Valve Management.

BACKGROUND: Calcific aortic stenosis (AS) is the most relevant valvular heart disease in aging populations and remains both underdiagnosed and undertreated. Screening studies reveal a high prevalence ...

Atrial Fibrillation Burden and Early Mitral Valve Remodelling in Patients Without Significant Mitral Regurgitation: A 3D Transesophageal Echocardiographic Study.

BACKGROUND: The progression of mitral valve (MV) remodelling in atrial fibrillation (AF) patients without significant mitral regurgitation (MR) remains poorly characterized. We aimed to determine whet...

Aerobic Endurance Training Modulates Cardiac Renin-Angiotensin System Peptides and Matrix Metalloproteinase Activity During Chronic Stress.

To investigate the involvement of metalloproteinases (MMPs) in the context of endurance training and their interactions with renin-angiotensin signalling (RAS) in stress-induced pathophysiological res...

Left Atrial Strain Prediction of New-Onset Atrial Fibrillation in Apical Hypertrophic Cardiomyopathy with Cardiac MRI.

Purpose To evaluate the predictive value of cardiac MRI-derived left atrial strain (LAS) for new-onset atrial fibrillation (AF) in apical hypertrophic cardiomyopathy (AHCM). Materials and Methods This...

Prognostic Value of Cardiac MRI-derived Left-to-Right Global Longitudinal Strain Ratio in ST-Elevation Myocardial Infarction.

Purpose To investigate the association between biventricular imbalance, as reflected by the left ventricular (LV) and right ventricular (RV) global longitudinal strain (GLS) ratio derived from cardiac...

Neurodegenerative and Cognitive Consequences of Long COVID.

The SARS-CoV-2 virus has infected approximately 778 million people worldwide since the pandemic. Patients who have survived coronavirus disease (COVID-19) may experience long-term symptoms related to ...

Cardiometabolic Aging Driven by Multi-Organ Crosstalk: Mechanisms and Therapeutic Strategies.

Cardiac senescence is not an isolated organ decline but a systemic consequence driven by pathological crosstalk between the heart and its peripheral metabolic organs. In this review, we discard the tr...

Ophthalmic Artery Doppler Indices and Maternal Factors in the Prediction of Preeclampsia in a High-Risk Obstetric Population: A Prospective Cohort Study.

AIM: To evaluate the utility of ophthalmic artery Doppler (OAD) indices, combined with maternal clinical factors, mean arterial pressure (MAP), and uterine artery pulsatility index (UtA-PI), for the p...

Right Ventricular Function and Pulmonary Arterial Coupling in Paediatric Obstructive Sleep Apnea.

PURPOSE: Right ventricular (RV) dysfunction and increased pulmonary arterial (PA) pressure may occur in children with obstructive sleep apnea (OSA). Long-term data on RV-PA coupling in children with O...

Development of a Diagnostic Model Based on Serum ST2 and Left Atrial Strain for Left Ventricular Systolic Dysfunction in Patients With Chronic Coronary Syndrome.

AIMS: The study investigated the predictive value of serum soluble ST2 (sST2) and left atrial strain parameters for left ventricular systolic dysfunction (LVSD), and the correlation analysis with corr...

Three-dimensional Speckle Tracking Imaging to Assess Subclinical Myocardial Mechanical Alterations in Patients With Type 2 Diabetes Mellitus Combined With Subclinical Hypothyroidism.

OBJECTIVE: This study aimed to evaluate subclinical myocardial mechanical alterations by utilizing three-dimensional speckle tracking imaging (3D-STI) in patients with type 2 diabetes mellitus (T2DM) ...

CSF fibrinogen predicts longitudinal Tau accumulation in cognitively unimpaired older adults.

INTRODUCTION: Blood-brain barrier (BBB) dysfunction is an early feature of Alzheimer's disease (AD). Fibrinogen represents a sensitive marker of BBB leakage, but whether it modifies longitudinal tau p...

Pretreatment Coronary Ultrasound Radiomics Combined With the Prognostic Nutritional Index for Predicting IVIG Resistance in Children With Kawasaki Disease.

BACKGROUND: Intravenous immunoglobulin (IVIG) resistance in children with Kawasaki disease (KD) is associated with an increased risk of coronary artery injury and subsequent adverse cardiovascular out...