Comparative evaluation of left atrial appendage occlusion and oral anticoagulation: a Bayesian meta-analysis of randomized controlled trials.

AIMS: Randomized trials comparing percutaneous left atrial appendage occlusion (LAAO) with oral anticoagulation (OAC) for stroke prevention in patients with atrial fibrillation have yielded conflictin...

Long-term efficacy and safety of left atrial appendage closure vs. oral anticoagulation in atrial fibrillation: a meta-analysis of randomized controlled trials.

AIMS: Left atrial appendage closure (LAAC) has emerged as an alternative to oral anticoagulation (OAC) for stroke prevention in atrial fibrillation (AF), but its long-term comparative efficacy remains...

Histological evaluation of clinically defined atrial cardiomyopathy stages and their association with atrial fibrillation burden under continuous monitoring for a 2.5-year follow-up.

BACKGROUND AND AIMS: Atrial cardiomyopathy (AtCM) is associated with atrial fibrillation (AF). While histological studies describe underlying mechanisms of AtCM, these insights remain disconnected fro...

Cervical Heterotopic Mouse Heart Transplantation using End-to-side Anastomosis Technique to Study Transplant Immunology.

Murine heterotopic heart transplantation is a critical preclinical model in transplantation research. Cervical heterotopic heart transplantation in mice offers distinct advantages, including direct vi...

Endoscopic endonasal resection of the cavernous sinus medial wall for functioning pituitary adenomas: A propensity score-matched retrospective cohort study.

Functioning pituitary adenomas (FPAs) account for 63% to 85% of pituitary adenomas. Although endoscopic endonasal surgery targets biochemical remission and reduced recurrence, cavernous sinus medial w...

Association between gout duration and subclinical carotid arterial stiffness in male patients with gout: A retrospective observational study.

Gout has been associated with an increased risk of cardiovascular disease, but direct evidence on carotid vascular changes in patients with gout remains limited. This study evaluated carotid arterial ...

PCSK5 promotes angiogenesis and cardiac repair after myocardial infarction.

PCSK5 (proprotein convertase subtilisin/kexin 5) is essential for heart development. However, its role in myocardial infarction (MI) remains unexplored. In this study, we found that the plasma levels ...

Targeting astrocytic Dp71 attenuates BBB disruption after traumatic brain injury through WTAP-associated m(6)A regulation of MMP2.

Blood-brain barrier (BBB) disruption is a major pathological feature of traumatic brain injury (TBI) that contributes to secondary damage and poor neurological recovery. Although astrocytes are essent...

Clinical outcomes and haemodynamic evolution following Perceval sutureless aortic valve implantation in high-risk aortic stenosis patients.

BACKGROUND: Sutureless aortic valve replacement (AVR) has been recognised as a potential option in the management of High-risk patients, characterised by reduced procedural times and satisfactory haem...

Totally endoscopic three-dimensional tricuspid valve repair in an adult with Ebstein's anomaly.

We report the case of a 52-year-old woman with severe tricuspid regurgitation due to Ebstein's anomaly. She underwent surgery through a 2.5 cm right minithoracotomy incision under three-dimensional en...

Root replacement after transcatheter aortic valve replacement in homograft explant.

We present the case of a young man with a prior homograft root replacement and a subsequent transcatheter aortic valve-in-valve, who presented with a root pseudoaneurysm and severe aortic regurgitatio...

Errate: Limb-Salvage Outcomes of Arterial Repair Beyond Time Limit at Different Lower-Extremity Injury Sites.

The authors wish to correct the following statement in the Abstract. The sentence: "Amputations were performed in 16 patients due to non-viable limbs, progressing infection, or muscle necrosis." shoul...

Clinical and donor-site outcomes of DIEP versus TRAM flaps in post-mastectomy breast reconstruction: a systematic review and meta-analysis.

BACKGROUND: Autologous breast reconstruction continues to be a cornerstone of post-mastectomy reconstruction, with abdominally based flaps providing reliable aesthetic and functional outcomes. Of thes...

Microsurgical clipping of paraclinoid aneurysms: a 12-year single-centre experience with surgical nuances and outcomes.

Paraclinoid aneurysms, arising from the internal carotid artery between the proximal dural ring and the posterior communicating artery, pose significant microsurgical challenges due to their proximity...

Dual-mode analysis of ischemic stroke based on urine SERS spectra and carotid B-ultrasound.

Achieving noninvasive high-frequency monitoring of ischemic stroke (IS) remains a major clinical challenge for timely intervention and precise secondary prevention. Establishing precise correlations b...

Effects of Prolonged Normobaric Hypoxia and Norepinephrine on the Rat Heart-Can They Be Reversed by Normoxic Recovery?

Previous studies on rats showed a deterioration of left ventricular (LV) function and myocardial injury characterized by oxidative/nitrosative stress, PARylation, and apoptosis in the heart after thre...

Outcomes after heart valve surgery for adult patients with active Enterococcus faecalis infective endocarditis: a 20-year, national, retrospective, observational cohort study in Aotearoa New Zealand.

BACKGROUND: The post-surgical duration of antibiotic treatment for patients with active infective endocarditis (IE), receiving heart valve surgery is uncertain. We aimed to assess the antibiotic treat...

Differentiation of human induced pluripotent stem cells into cardiac valve cells using 2D and 3D differentiation protocols.

BACKGROUND: Given the high relevance of human cardiac valve disease, recent research aims to differentiate human induced pluripotent stem cells (hiPSCs) into valve endothelial-like cells (VELCs) and, ...

Electroanatomical properties and high-density mapping guided targeted isolation of superior vena cava.

INTRODUCTION: Superior vena cava isolation (SVCI) is associated with complications such as sinus node (SN) and phrenic nerve (PN) injury or SVC stenosis. Our study assessed the electrophysiological pr...

Cryopreservation alters contractile function of human induced pluripotent stem cell-derived cardiomyocytes.

Advanced protocols are available for efficient generation of large quantities of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Nevertheless, hiPSC-CMs show large batch to bat...