Neuroinvasive Free-Living Amoebae Pathogenesis, Neuroinflammation and Therapeutic Challenges.
Neuroinvasive free-living amoebae (FLA), particularly Naegleria fowleri and Acanthamoeba spp., are responsible for rare but devastating infections of the central nervous system (CNS). Approximately 48...
Circadian regulation of cardiovascular function: from physiology to clinical implications.
Circadian rhythms play a crucial role in maintaining cardiovascular homeostasis, orchestrating fluctuations in blood pressure, heart rate variability, endothelial function, and systemic vascular tone....
Voluntary wheel running reduces infarct size through thioredoxin-1 and survival pathways.
Ischemic heart disease remains the leading cause of mortality worldwide, and exercise is recognized as one of the most effective non-pharmacological strategies for cardioprotection. Voluntary wheel ru...
Segmental vertebral artery agenesis with deep cervical reconstitution in a cervicothoracic variant cluster.
PURPOSE: To report a complex cervicothoracic vascular-osseous phenotype detected on CTA and define its surgical and radiological relevance. METHODS: Neck CTA of a 76-year-old woman was reviewed on mul...
Prosthesis-patient mismatch with intra-annular self-expanding valves: an analysis of the PORTICO IDE trial.
BACKGROUND: Aortic valve replacement in small aortic annuli is associated with an increased risk of impaired haemodynamics. AIMS: We sought to evaluate haemodynamic outcomes and prosthesis-patient mis...
Left atrial appendage closure with the AnchorMan or Watchman devices: 12-month results of the SAFE-PROTECT randomised trial.
BACKGROUND: Percutaneous closure of the left atrial appendage (LAA) is an alternative to chronic oral anticoagulation to reduce stroke risk in patients with non-valvular atrial fibrillation (AF). AIMS...
Computer modeling to improve measurement of stroke volume with echocardiography.
BACKGROUND: The stroke volume (SV) can be measured by a human expert (HE) using the left ventricular outflow tract diameter (LVOTd) and its velocity time integral (VTI) with echo. If the SV is known, ...
Heart failure with preserved ejection fraction (HFpEF) is a poorly understood, multisystem disease with high morbidity and mortality. To improve understanding of its pathobiology, we analyzed single-n...
Although pulmonary arterial hypertension (PAH) is a rare and fatal disease that is well-characterized, vasodilator-responsive PAH accounts for a minority of cases, with little mechanistic knowledge, b...
Heart failure remains a major global health burden, driven largely by pathological cardiac hypertrophy. Mitochondrial dysfunction, particularly impaired mitochondrial complex I activity, is central to...
Atherothrombosis, which underlies most acute coronary syndromes and is driven by intraplaque thrombosis, preferentially occurs in regions of disturbed blood flow (d-flow). Although LATS1/2 (large tumo...
Incremental Value of Iodine-125 Seed Implantation After Bronchial Artery Chemoembolization in Immunotherapy-Treated Advanced Lung Squamous Cell Carcinoma with Hemoptysis: A Retrospective Cohort Study Using Inverse Probability of Treatment Weighting.
BACKGROUND: The incremental value of iodine-125 (I-125) seed implantation in advanced refractory lung squamous cell carcinoma (LUSC) with hemoptysis treated with bronchial artery chemoembolization (BA...
The Role of Hydrogen Bond Donors and Intramolecular Hydrogen Bonding in Modulating Blood-Brain Barrier Permeability: Implications for CNS Drug Design.
The blood-brain barrier (BBB) represents a major challenge in central nervous system (CNS) drug development due to its selective permeability. Multiple molecular properties such as lipophilicity, mole...
Vascular reprogramming in cancer: engineering the tumor microenvironment.
Tumor vasculature has traditionally been viewed as structurally and functionally abnormal and, therefore, is primarily targeted for inhibition. However, emerging evidence from vascular biology, regene...
Surgical Septal Myectomy and Atrial Myxoma Resection: Two Diseases, One Heart, and a Case Report.
BACKGROUND The coexistence of cardiac myxoma and hypertrophic cardiomyopathy is exceedingly rare and poses diagnostic and therapeutic challenges. While atrial myxomas may cause acute hemodynamic compr...
Stem cell-based regenerative therapies for non-ischemic cardiomyopathy: mechanistic insights, clinical evidence, and future directions.
Non-ischemic cardiomyopathy (NICM) includes a wide spectrum of myocardial disorders that result in ventricular dysfunction in the absence of significant coronary artery disease. The currently availabl...
Case report: exercise-associated sudden death in a Thoroughbred racehorse with cardiac lesions.
Exercise-associated sudden death (EASD), defined as acute collapse and death in an apparently healthy racehorse during or within ~1 h after exercise, is currently among the top concerns in the racing ...
Non-transferrin-bound iron uptake by cardiomyocytes.
Under conditions of iron overload, increased non-transferrin-bound iron (NTBI) can gain access to cardiomyocytes, cause cardiac iron accumulation and generate reactive oxygen species which can result ...
Focused ultrasound-mediated blood-brain barrier opening to enhance temozolomide delivery in glioblastoma: a systematic review of preclinical and early clinical evidence.
Glioblastoma (GBM) is the most aggressive primary malignant brain tumor in adults, with persistently poor survival despite chemoradiation and temozolomide (TMZ). Limited intratumoral drug delivery imp...
Nanocarrier-based targeting strategies in epilepsy: addressing pathophysiological barriers.
OBJECTIVES: Epilepsy is a chronic neurological disorder affecting nearly 50 million people worldwide and is characterized by recurrent seizures caused by abnormal neuronal activity. Conventional thera...