Nailfold Videocapillaroscopy in Pediatric Rheumatology: Established Roles, Emerging Applications, and Future Perspectives.

Nailfold videocapillaroscopy (NVC) provides direct, non-invasive access to the peripheral microcirculation and has become a central tool in adult rheumatology. Its primary clinical value lies in the e...

From Cutaneous Necrosis to Septic Shock: An ICU Case of Pancreatico portal Fistula Complicating Necrotizing Acute Pancreatitis.

BACKGROUND: Pancreaticoportal fistula is an exceptionally rare and potentially fatal vascular complication of necrotizing pancreatitis. Its clinical presentation can be atypical, leading to delayed di...

How to apply the DAZE technique: structured approach to fetal cardiac image optimization.

Accurate prenatal detection of congenital heart disease continues to be challenging in routine obstetric practice, despite established screening guidelines. Missed diagnoses are frequently associated ...

Aflibercept and Faricimab Equipotently Restore Endothelial Barrier Function.

PURPOSE: To study the biological effects of aflibercept and faricimab on vascular endothelial growth factor (VEGF)-A165-induced vascular permeability in an in vitro head-to-head comparison using human...

Explicit Inclusion of Diabetes Mellitus Without Retinopathy Within Diabetic Retinopathy Prediction.

PURPOSE: The purpose of this study was to evaluate whether explicitly modeling diabetes mellitus (DM) without diabetic retinopathy (DR) as its own stage enables deep learning (DL) to detect early reti...

Totally implantable venous access port implantation in a breast cancer patient with situs inversus totalis: A case report.

Situs inversus totalis, a rare congenital condition characterized by complete mirror-image transposition of the thoracic and abdominal organs, has not previously been reported in patients with breast ...

PGC-1α-Nrf2 Signaling Imbalance Mediates Doxorubicin-Induced Mitochondrial Dysfunction and Cardiac Injury.

Doxorubicin (DOX)-induced cardiotoxicity is characterized by mitochondrial dysfunction and oxidative stress; however, the mechanistic interplay between mitochondrial metabolic regulation and antioxida...

The Interplay Between Sleep Disturbance, Glymphatic Dysfunction and Altered Brain Networks in Internet Gaming Disorder: A Multimodal Neuroimaging Study.

Sleep disturbances are common in individuals with Internet gaming disorder (IGD), yet the neurobiological links between poor sleep quality and addictive symptoms remain unclear. The glymphatic system ...

Massive haemoptysis secondary to pulmonary artery aneurysms in Hughes-Stovin syndrome: a variant of Behçet's disease managed with immunosuppression and endovascular embolisation.

We report a rare and potentially life-threatening case of a young male with Behçet's disease complicated by Hughes-Stovin syndrome who presented with massive haemoptysis secondary to multiple pulmonar...

Reversible visual loss in biopsy-proven giant cell arteritis.

A late 60s man presented with a 1-week history of recurrent transient monocular visual loss in his left eye, followed by sudden, severe visual loss and eyelid pain. Examination revealed a left relativ...

Cervicothoracic screwdriver impalement causing traumatic aortic injury managed with TEVAR.

Penetrating neck injuries are uncommon but carry high mortality due to the proximity of major vessels and the aerodigestive tract. We report a woman in her 80s who presented with a 40-cm flat-head scr...

Anti-endothelin receptor A autoantibodies associate with immunovascular risk and activate endothelial signalling in SLE.

OBJECTIVE: Cardiovascular disease in SLE is not fully explained by traditional risk factors, supporting a role for disease-specific immunovascular mechanisms. Autoantibodies targeting endothelin recep...

Incidence and Risk Factors of Catheter-Related Thrombosis in Oncology Patients With Internal Jugular and Subclavian Implanted Ports: A Retrospective Single-Center Study.

OBJECTIVE: This study compared the clinical characteristics of catheter-related thrombosis (CRT) associated with internal jugular and subclavian vein-implanted ports. METHODS: This retrospective study...

Neurotensin receptor 2 agonism attenuates adverse cardiac remodeling in preclinical models.

The neuropeptide neurotensin (NTS) is up-regulated in cardiac lymphatic endothelial cells (LECs) in response to ischemic or mechanical damage, but its role in cardiac remodeling is unknown. Here, we a...

Degeneration of Interpericyte Tunneling Nanotubes Can Occur in the Absence of Pericyte Loss in Diabetic Retina Disease.

PURPOSE: Interpericyte tunneling nanotubes (IP-TNTs) synchronize pericyte-pericyte communication and regulate microvascular perfusion, processes disrupted in early diabetic retina disease (DRD). We co...

Clinical Characteristics and Technical Outcomes of Microballoon Catheter-assisted Partial Splenic Embolization.

BACKGROUND/AIM: Partial splenic embolization (PSE) is an established interventional radiology procedure for portal hypertension. However, in cases of splenomegaly with complex vascular anatomy, guide ...

Exploring mechanisms for reversal of flow in tunicate hearts.

Ascidians, a class of tunicates, are marine invertebrates with valveless, tubular hearts. Recent experiments suggest that the hearts of Ciona robusta have two distinct pacemakers, one at each end of t...

Quantitative optical coherence tomography angiography analysis of retinal capillary plexuses in diabetic eyes: Impact of phakic and pseudophakic status.

BACKGROUND: Optical coherence tomography angiography (OCTA) has revolutionized the evaluation of retinal microvasculature by enabling noninvasive quantification of capillary networks and the foveal av...

Minute-level ECG-derived autonomic dynamics around obstructive apnea events: A peri-event analysis of the PhysioNet apnea-ECG database.

BACKGROUND: Obstructive sleep apnea (OSA) is linked to arrhythmia and cardiovascular morbidity, but the cardiac response to individual obstructive events is incompletely characterised at minute-scale ...

RNF113A Protects Against Sepsis-Induced Myocardial Injury via Activation of the Keap1/Nrf2 Axis to Reduce Ferroptosis.

Sepsis-induced myocardial injury (SIM) is a common complication of sepsis that can cause high morbidity and mortality. However, the molecular mechanisms underlying SIM have still not been fully elucid...