Interrelations of aortic spring function, cardiovascular disease risk factors, and left ventricular diastolic function: The Framingham Heart Study.
Mechanical twisting and untwisting of the left ventricle as well as abnormal hemodynamic aortic-ventricular coupling are recognized as contributors to left ventricular diastolic function. However, ene...
Dapagliflozin Improves Mitochondrial Function to Reduce the Risk of Atrial Fibrillation in a High-Glucose Environment by Activating the AMPK/PGC-1α/SIRT3 Signalling Pathway.
BACKGROUND: Type 2 Diabetes Mellitus (T2DM) and AF (Atrial Fibrillation) frequently coexist, amplifying cardiovascular risks via shared mitochondrial dysfunction involving metabolic dysregulation, oxi...
Application of conventional ultrasound-based carotid grading system in assessing disease activity and monitoring progression in Takayasu arteritis.
OBJECTIVE: This study aimed to evaluate and validate the utility of a conventional ultrasound-based carotid grading system in assessing disease activity in Takayasu arteritis (TA) with carotid artery ...
Novel strategies to overcome the blood-brain barrier in triple-negative breast cancer brain metastases.
Triple-negative breast cancer-the most aggressive breast cancer subtype-has a high propensity for brain metastases, with limited treatments and poor prognosis. The blood-brain barrier, long viewed as ...
Microvessel Maturation Correlates With Doppler Ultrasound Indices and Vascular Invasion in Follicular Thyroid Tumors.
BACKGROUND/AIM: Preoperative assessment of vascular invasion in follicular thyroid tumors remains challenging. Although quantitative Doppler indices, such as the resistive index (RI) and pulsatility i...
Inferior Vena Cava Ultrasound for Decongestion Assessment in Acute Heart Failure: Systematic Review.
BACKGROUND: Residual congestion at discharge in acute heart failure (AHF) is a primary driver of readmission and mortality. Inferior vena cava (IVC) ultrasound provides a noninvasive bedside assessmen...
Ethanol Infusion Into the Vein of Marshall for Atrial Fibrillation: Clinical Efficacy and Technical Limitations.
BACKGROUND: Despite advancements in radiofrequency ablation (RFCA) technology and strategy, the long-term rhythm outcomes of persistent atrial fibrillation (PeAF) remain suboptimal. Since the vein of ...
Carbon Dioxide Concentration Alters the Dynamics of Oxygen-Mediated Capillary Blood Flow Responses in Skeletal Muscle.
HYPOTHESIS: We hypothesize that the dynamics of O2-mediated blood flow responses in skeletal muscle capillaries are altered under different tissue carbon dioxide concentrations ([CO2]) due to the inte...
Diabetes Upregulates BK(Ca) Channels in Pulmonary Arterial Smooth Muscle by Altering the Local Control Mechanism of the Pore-Gate Domain.
OBJECTIVE: Large conductance calcium-activated potassium channels (BKCa) play an important role in the regulation of vascular tone. However, the properties of BKCa channels in smooth muscle of pulmona...
Multi-Center Adversarial Bi-Phase Cross-Attention Network for Right Ventricular Segmentation and Functional Classification in Echocardiography.
BACKGROUND: Automated right ventricular (RV) analysis in 2D echocardiography is limited by the morphological complexity of RV segmentation and the domain fragility of single-center deep learning model...
Uterine artery pseudoaneurysm: Rare cause of delayed postpartum hemorrhage.
OBJECTIVE: To identify a rare but potentially life-threatening cause of delayed postpartum hemorrhage. CASE REPORT: A 36-year-old woman, gravida 1, para 1, had just underwent cesarean section at a loc...
Inpatient Outcomes and Complications After Left Atrial Appendage Occlusion in Rural Versus Urban Hospitals in the United States.
BACKGROUND: Disparities in management of atrial fibrillation in rural and urban hospitals across the U.S. have been reported. However, studies investigating disparities regarding outcomes and complica...
Clinical analysis of postmenopausal women with intravenous leiomyomatosis.
OBJECTIVE: Intravenous leiomyomatosis is a rare disease that occurs in premenopausal women. We examined the clinical characteristics, diagnosis, and therapeutic approaches of intravenous leiomyomatosi...
Cerebral arteries segmentation based on projection domain in single exposure computed tomographic angiography.
BACKGROUND: Cerebrovascular diseases are major causes of death and disability worldwide, highlighting the critical importance of early diagnosis and accurate acquisition of vascular information. Howev...
The Prognostic Value of CRP/Albumin Ratio in Prediction of Limb Salvage in Patients with SFA Lesion According to TASC II Classification After Endovascular Treatment: A Pilot Study.
BACKGROUND: Higher systemic inflammation may portend worse limb outcomes after endovascular therapy (EVT). We assessed whether the pre‑procedural C‑reactive protein/albumin ratio (CAR) predicts major ...
Left atrial strain and right ventricular mechanics in advanced heart failure: a prospective observational study.
PURPOSE: Left atrial reservoir strain (LASr) is an established marker of atrial dysfunction and elevated filling pressures in heart failure; however, its role in mediating downstream right ventricular...
Defining reference intervals for submaximal cardiopulmonary exercise testing-derived gas-exchange derived pulmonary capacitance in older adults.
BACKGROUND: Gas-exchange derived pulmonary capacitance (GXCAP) is a non-invasive index of pulmonary arterial capacitance obtainable from submaximal cardiopulmonary exercise testing (CPET), but referen...
A new in silico model to precisely design focused ultrasound brain therapies.
BACKGROUND: Focused ultrasound (FUS) combined with microbubbles enables transient and noninvasive blood-brain barrier (BBB) opening, facilitating targeted drug delivery. However, accurate treatment pl...
A Non-Channel Function of CFTR: Attenuating Mitochondrial Oxidative Stress and Cardiomyocyte Senescence via Stabilization by USP45.
Cardiomyocyte senescence drives cardiovascular disease, underscoring the need to define its molecular mechanisms. The role of cystic fibrosis transmembrane conductance regulator (CFTR) ion channel in ...
Cellular Heterogeneity During Arterial Aging.
Arterial aging is a major risk factor for cardiovascular disease and is associated with progressive changes in vascular structure and function, including arterial stiffening, reduced elasticity, extra...