FLVCR2 Regulation of Intracellular Heme Modulates Vascular Tip/Stalk Specification During Retinal Angiogenesis.
PURPOSE: Fowler syndrome is an embryonic lethal disease with proliferative vasculopathy and hydranencephaly-hydrocephaly of the central nervous system caused by mutations in feline leukemia virus subg...
Glutamate carboxypeptidase II activation in astrocytes mediates glymphatic impairment and cognitive vulnerability in the aging brain following surgery.
INTRODUCTION: Perioperative neurocognitive disorder is a common and debilitating complication in the elderly, yet its cellular and molecular mechanisms in the aging brain remain poorly understood. MET...
Myocardial Immune Niches in Homeostasis and Inflammation.
The heart functions as a circulatory pump that supplies blood throughout the body. The execution of this critical function depends on the interplay between cardiomyocytes and the supportive cellular i...
Colchicine as an Adjunctive Therapy to Improve Ischemic Stroke Reperfusion Outcomes in Mice.
BACKGROUND: Mechanical thrombectomy (MT) has become a cornerstone therapy for acute ischemic stroke (AIS) caused by large-vessel occlusion; however, incomplete microvascular reperfusion and blood-brai...
Entropy for Prediction of MACEs in Myocarditis: A Cardiac MRI-based Biomarker of Myocardial Tissue Heterogeneity.
Background The prognostic value of left ventricular (LV) entropy in acute myocarditis is unclear. Purpose To assess the association of LV entropy, a measure of myocardial heterogeneity derived from ca...
Hyperdense Capsule Sign at Noncontrast CT as an Indication for Middle Meningeal Artery Embolization for Nonacute Subdural Hematomas: A MAGIC-MT Trial Post Hoc Analysis.
Background Hematoma recurrence and progression remain common challenges in nonacute subdural hematomas (SDHs). The understanding of indications for middle meningeal artery embolization (MMAE) is limit...
Isosmotic hypovolemia preserves inverse neurovascular coupling in the supraoptic nucleus during heart failure.
Vasopressin (AVP) neurons in the hypothalamic supraoptic nucleus (SON) are activated by systemic challenges that threaten fluid balance. We previously showed that a systemic salt challenge triggers in...
"A Case of Anomalous Systemic Venous Connections to Left Sided Atrium in Left Isomerism".
A 7-month-old infant with Tetralogy of Fallot physiology showed disproportionate left heart dilatation. Multisite saline contrast echocardiography demonstrated immediate left sided atrial opacificatio...
Advancing Retinal Vessel Analysis: Reproducibility of Myogenic Constriction and Assessment of Regulatory Capacity.
PURPOSE: Accurate characterization of retinal microvascular autoregulation requires reliable assessment of both vasodilatory and vasoconstrictive responses. Although blood pressure (BP)-induced vasoco...
Roles of Microglia in Cerebral Small Vessel Disease.
BACKGROUNDS: Cerebral small vessel disease (CSVD) is a major cause of vascular dementia, characterized by heterogeneous pathologies affecting the brain's microvasculature. In recent years, researchers...
Superficial Palmar Branch of the Radial Artery, Medial Plantar Artery Perforator, and Medial Sural Artery Perforator Free Flaps in Digital Soft Tissue Reconstruction: Comparisons of Clinical Outcomes From a Retrospective Institutional Series.
INTRODUCTION: Digital defects requiring soft tissue reconstruction are still challenging. There is no first-choice free flap for digital reconstruction, although various free flaps were used to recons...
Lymphovenous Anastomosis for Treatment of Breast Lymphedema Following Delayed Autologous Reconstruction: A Case Report.
Breast lymphedema (BLE) is an underrecognized sequela of breast cancer treatment that can lead to chronic swelling, pain, and recurrent infections. While lymphovenous anastomosis (LVA) is well establi...
Left Atrial Appendage Mechanical Dysfunction in De Novo Organized Left Atrial Tachyarrhythmia: A Multicenter Pre-Ablation Study.
PURPOSE: Whether de novo organized left atrial tachyarrhythmia (LAT) shows preserved left atrial appendage (LAA) mechanics has not been adequately characterized. We compared LAA peak emptying velocity...
Basilar thrombolysis in cerebral infarction (bTICI) scale: Proposal and preliminary validation of a basilar reperfusion score based on digital subtraction angiography to evaluate the efficacy of mechanical thrombectomy in acute basilar artery occlusion.
OBJECTIVES: Basilar artery occlusion (BAO) accounts for 10% of all ischemic strokes due to largevessel occlusion (LVO) and is associated with highest mortality and disability rate. The aim ofthis stud...
Adrenal venous sampling: Indications and technical challenges.
Adrenal venous catheterisation is a procedure used in the aetiological diagnosis of primary aldosteronism (PA). Its purpose is to measure aldosterone and cortisol levels in blood samples obtained from...
Overexpression of Circular RNA circTTN Promotes Ferroptosis in Sepsis-Induced Cardiomyopathy.
Sepsis-induced cardiomyopathy (SCM) is one of the common complications caused by sepsis. Despite the higher mortality rate associated with SCM, the pathogenesis of SCM is poorly understood. The study ...
Focused ultrasound-induced blood-brain barrier modulation for drug delivery in recurrent glioblastoma: A systematic review.
Background and objectives Glioblastoma is the most aggressive primary adult central nervous system of malignancy, with a median overall survival of 12-18 months. Recurrence is almost inevitable and ca...
Mechanisms and integrative machine learning approaches to blood-brain barrier biomarker profiling for personalized ischemic stroke management.
Ischemic stroke remains a leading cause of death and disability worldwide, with blood-brain barrier (BBB) disruption playing a central role in vasogenic edema, neuroinflammation, hemorrhagic transform...
Valsartan Reduces Myocardial Ischemia-Reperfusion Injury by Inhibiting Ferritinophagy-Mediated Ferroptosis.
Revascularisation is the key therapeutic strategy for acute myocardial infarction (AMI). However, the opening of the 'culprit artery' is accompanied by myocardial ischemia-reperfusion injury (IRI), pa...
Beyond Viral Control: Tenofovir's Hidden Impact on Blood-Brain Barrier Endothelial Cells.
UNLABELLED: The blood-brain barrier (BBB) is a dynamic endothelial interface that protects the brain from harmful agents while regulating molecular exchange. Human immunodeficiency virus (HIV) comprom...