Cardioprotective Effect of Aloin Against Ischemia/Reperfusion Injury: Experimental and Computational POM Approaches.
This study investigates the antihypertensive, antioxidant, and cardioprotective effects of Aloin following Langendorff rat isolated heart technique, the main bioactive compound of Aloe vera L., using ...
Outcomes of Liver Transplant Versus Partial Hepatectomy for Perihilar Cholangiocarcinoma Patients Requiring Arterial Reconstruction.
BACKGROUND AND AIMS: Liver resection (LR) and orthotopic liver transplantation (OLT) are therapeutic options for locally advanced perihilar cholangiocarcinoma (pCCA) requiring hepatic artery reconstru...
An Outflow Tract Myocardium-Specific Enhancer at the Sema3c Locus During Heart Development.
Sema3c is specifically expressed in the cardiac outflow tract (OFT) of the developing mouse heart and has been implicated in OFT polarization and great artery formation. However, the regulatory basis ...
Preoperative MRI Model for Predicting Inferior Vena Cava Wall Invasion in Renal Cell Carcinoma with Tumor Thrombus.
Purpose To develop and evaluate a preoperative MRI-based model for predicting inferior vena cava (IVC) wall invasion in renal cell carcinoma (RCC) with IVC tumor thrombus (IVCTT) and to compare its pe...
Evaluating the Efficacy and Utility of Preoperative Computed Tomography Angiography in Perforator Flap Surgeries: A Systematic Review and Meta-Analysis.
BACKGROUND: Deep inferior epigastric artery perforator (DIEP) flaps are widely used in autologous breast reconstruction and increasingly favored due to superior patient-reported outcomes. Preoperative...
Recipient Vessel Selection in Free Flap Phalloplasty: A Systematic Review and Single-Arm Meta-Analysis.
BACKGROUND: Selection of recipient vessels in phalloplasty is challenging due to the absence of adequate vessels in the immediate proximity. There is no consensus on the appropriate vessel selection. ...
Nebivolol Protects the Thoracic and Abdominal Aorta and Their Perivascular Adipose Tissue From the Differential Detrimental Effects of Obesity.
The effects of obesity on the vasculature and perivascular adipose tissue (PVAT) function vary according to the vascular territory. Nebivolol is a third-generation β-blocker that exerts vasculoprotect...
Crataegus oxyacantha Extract Enhances Cardiac Adaptation and Reduces Oxidative-Inflammatory Stress in Broiler Chickens Raised at High Altitude Under Cold Stress.
BACKGROUND: Cold stress and high-altitude hypoxia cause pulmonary hypertension syndrome (PHS) in broilers via cardiac overload, oxidative-inflammatory stress, and ET-1/NO imbalance. OBJECTIVES: This s...
Echocardiographic Findings in Small-Breed Dogs With Myxomatous Mitral Valve Disease and the Severity of Mitral Regurgitation, Heart Size and Clinical Signs Myxomatous Mitral Valve Disease in Dogs.
BACKGROUND: The main goal of this study was to identify various brightness, motion and Doppler echocardiographic variables in small-breed dogs with myxomatous mitral valve disease. ANIMALS: Sixty clie...
Pinoresinol diglucoside from Eucommia ulmoides attenuates diabetic cardiomyopathy through suppressing the store-operated calcium entry and downregulating the STIM1/Orai1/NFAT3 signaling pathway.
Pinoresinol diglucoside (PDG), an active component derived from Eucommia ulmoides, exhibits therapeutic effects against apoptosis, inflammation, and hypertrophy, etc. However, whether PDG plays a prot...
Targeting vascular smooth muscle cells with natural compounds to combat atherosclerosis.
Atherosclerosis (AS) is widely recognized as the principal pathological substrate underlying chronic cardiovascular diseases (CVDs). It is a chronic, progressive, and inflammatory disease characterize...
Battle of the wall for aromatic "orifice-opening" agents: defending and breaching the blood-brain barrier.
The brain is the most stringently safeguarded organ in the human body. The 7-mm-thick cranial vault shields the central nervous system (CNS) from external damage, while the blood-brain barrier (BBB) f...
Thermoneutrality Reveals True Cardiac Adaptations to Exercise, Disease, and Aging in Male Mice.
AIM: Standard laboratory housing (21°C) imposes chronic cold stress on mice, yet its fundamental impact on cardiac plasticity remains poorly defined. We systematically interrogated how environmental t...
The Distally Based Saphenous Neurocutaneous Perforator Flap: A Versatile Donor Site for Reconstruction of Complex Soft Tissue Defects of the Lower Leg.
BACKGROUND: Repair of both simple and complex defects in the distal lower leg continues to be a challenging task for reconstructive surgeons because of the local paucity of soft tissue available for t...
Preventive Antiarrhythmic Properties of Melatonin in Experimental Diabetic Cardiomyopathy in Rats.
Diabetes mellitus (DM) promotes cardiac arrhythmias, whereas melatonin confers antiarrhythmic effects. Cellular targets modified by DM and melatonin largely overlap, which warrants testing melatonin a...
Radial Artery Catheter Complications Based on Site, Dressing and Application Technique: A Descriptive Observational Study.
BACKGROUND: Radial artery catheters are commonly used in intensive care units to monitor the vital signs of patients. AIM: This study was carried out to evaluate the complications of radial artery cat...
Autoantibodies in Patients With Arrhythmogenic Cardiomyopathy Activate GSK-3β, Resulting in a Loss of Cardiomyocyte Cohesion.
BACKGROUND: Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac desmosome disease, as more than 50% of affected patients carry pathogenic variants in desmosome protein-coding genes. In this st...
The long-term risks of specific cardiovascular diseases (CVDs) among offspring exposed to various types of maternal diabetes in utero and the mechanisms underlying these risks remain unclear.
Non-high-density-lipoprotein (non-HDL) cholesterol and apolipoprotein B (apoB) are better markers of atherosclerotic cardiovascular disease (ASCVD) risk than low-density-lipoprotein cholesterol, but w...
Since 2018, the Resuscitation Quality Improvement (RQI) program to enhance cardiopulmonary resuscitation (CPR) training and skill retention has expanded to many US hospitals.