Oral Semaglutide and Change in Cardiovascular Risk Factors in High-Risk Type 2 Diabetes: A Post Hoc Secondary Analysis of the SOUL Randomized Clinical Trial.
Individuals with type 2 diabetes (T2D) are at high risk of atherosclerotic cardiovascular disease (ASCVD). In the SOUL randomized clinical trial, once-daily oral semaglutide reduced risk of major adve...
Mechanisms of GLP-1 Receptor Agonists in HFpEF: Exploring Weight-Dependent and Independent Drivers of Therapeutic Benefit.
Heart failure with preserved ejection fraction is a complex and increasingly prevalent condition often associated with metabolic comorbidities such as obesity, diabetes, and hypertension. Although its...
Transthyretin amyloid cardiomyopathy (ATTR-CM) remains underdiagnosed relative to population estimates in at-risk populations. Efforts have identified clinical features that identify risk for the diag...
Vascular smooth muscle cell (VSMC) phenotypic remodelling is pivotal to neointimal hyperplasia (NH), a common pathological response to vascular injury. COPS5/CSN5/JAB1 harbours the deneddylase of the ...
Hypertension-Associated Acetate Deficiency Enhances Platelet Activation and Thrombosis Via Olfr78.
Arterial thrombotic events constitute the leading cause of mortality in hypertension. Gut dysbiosis induces endothelial dysfunction and systemic inflammation, contributing to hypertension and its asso...
SARM1 Regulates BNIP3-Mediated Mitochondrial Quality Control in Diabetic Hearts.
Circulation research
Cardiovascular disease risk factors in young people with diabetes mellitus
The increasing prevalence of diabetes in young adults raises concerns regarding its early cardiometabolic consequences. This study aimed to evaluate cardiac function, renal markers, lipid profile, ins...
Midwall Late Gadolinium Enhancement and Native T1 Elevation in Chronic Myocarditis-Related Dilated Cardiomyopathy: An Evidence-Based Case Report.
BACKGROUND: Cardiovascular magnetic resonance (CMR) is the reference standard for non-invasive myocardial tissue characterization, with proven value in diagnosing and prognosticating myocarditis and n...
Successful Conservative Management of Right Ventricular Perforation Caused by Temporary Pacemaker Placement during Complex Percutaneous Coronary Intervention: A Case Report.
Cardiac tamponade is a critical condition that can result from complications during invasive cardiac procedures. This case report describes a 67-year-old male who developed right ventricular perforati...
[Mechanism of Dangua Humai Oral Liquid in ameliorating vascular endothelial injury in type 2 diabetes mellitus via HIF-1α].
This study investigated whether Dangua Humai Oral Liquid regulates glycolipid metabolism and vascular endothelial ultrastructure in the rat model of type 2 diabetes mellitus(T2DM) by regulating the ex...
[Discovery and preliminary verification of direct targets of active ingredients of Shuangshen Ningxin Capsules in preventing and treating myocardial ischemia-reperfusion injury].
Based on the magnetic bead "fishing" technology, this study explored the direct targets of the active ingredients of Shuangshen Ningxin Capsules in preventing and treating myocardial ischemi...
Evaluation of Pulse Wave Velocity using Transthoracic Echocardiography in Children with Bicuspid Aortic Valve.
BACKGROUND: Increased aortic stiffness in patients with bicuspid aortic valve (BAV) may significantly affect morbidity and mortality. OBJECTIVE: We aimed to evaluate aortic elasticity properties and t...
Hormone deficiency and cardiovascular disease: clinical impact, treatment strategies and prognostic prediction
Hormone deficiency states are increasingly recognized as important, yet often underappreciated, contributors to cardiovascular (CV) disease. Deficits affecting pituitary, thyroid, parathyroid, adrenal...
Cardiovascular PIEZO discovery continues apace to reveal myocardial nerves feeling posture and blood loss
The idea of myocardial mechanical reflexes was previously considered but it struggled to gain traction in mainstream thinking. New research shows PIEZO2 ion channels conferring vagal force sensing in ...
Multiomics for Risk Stratification in Atherosclerotic Cardiovascular Disease.
Circulation. Genomic and precision medicine
Differential effects of high-sucrose and high-fat diets on metabolic syndrome, BBB integrity, and hippocampal Aβ accumulation.
Metabolic syndrome (MS) is a global health problem and a recognized risk factor for cognitive impairment and Alzheimer's disease (AD), but the different effects of specific dietary components on MS-re...
High-fat diet-induced obesity affects sulfurtransferases activity in mice hearts.
INTRODUCTION: Obesity is a chronic disease with complex etiology, characterized by excessive accumulation of fat tissue, which poses a health hazard and increases, among others, risk of cardiovascular...
The relationship between cardiovascular risk level determined by SCORE2 and cardiovascular disease risk awareness and health literacy in individuals aged 40–69: a cross-sectional study
Cardiovascular diseases (CVD) are a major cause of morbidity and mortality worldwide. Individuals’ awareness of cardiovascular risk and levels of health literacy play a critical role in the pre...
Palliative care in cardiovascular medicine.
Cardiovascular disease remains the leading global cause of morbidity and mortality. Although advances in prevention, diagnostics, and disease-modifying therapies have prolonged survival, many individu...