[Molecular and systemic mechanisms of cognitive impairment associated with coronavirus infection].

Cognitive dysfunction represents a prevalent and long-lasting non-respiratory symptom following a protracted course of coronavirus infection, yet its molecular basis remains inadequately characterized...

Extracellular Vesicles in the Heart-Organ Axis: From Inter-Organ Communication to Precision Nanomedicine for Heart Diseases.

BACKGROUND: Heart diseases, including myocardial infarction and heart failure, remain the leading causes of morbidity and mortality worldwide, underscoring an urgent need for innovative diagnostic and...

Identification of novel peripherally restricted risperidone-like dopamine D2 receptor antagonists for prolactin-mediated neuroprotection through a multi-stage in silico screening.

Prolactin, a hormone with emerging neuroprotective roles, has demonstrated potential in mitigating cognitive impairment under specific neurotoxic conditions, including environmental toxicity and excit...

Aortic valve repair in 2026 - state of the art: what every cardiologist should know.

Aortic valve repair (AVr) has evolved into a reproducible surgical strategy for selected patients with aortic regurgitation (AR), offering preservation of native tissue, avoidance of prosthesis-relate...

Nailfold capillaroscopy in diabetic retinopathy: microvascular insights, clinical value, and translational challenges - a narrative review.

Diabetic retinopathy (DR) is a leading microvascular complication of diabetes mellitus and a major cause of preventable vision loss. DR is now viewed as a manifestation of systemic diabetic microangio...

Assessment of predictive factors for acute kidney injury after thrombectomy using AngioJet for iliofemoral deep vein thrombosis.

OBJECTIVE: To identify the relationship between acute kidney injury (AKI) and the treatment of iliofemoral deep vein thrombosis in the acute phase using an AngioJet® device. METHODS: This retrospectiv...

Dual Therapy vs. Single Anticoagulation After Acute Deep Vein Thrombosis Iliac Stenting: A Doubly Robust Multicenter Study.

BackgroundThe optimal antithrombotic strategy after iliac vein stenting for acute iliofemoral deep vein thrombosis (IFDVT) remains uncertain. We compared dual antithrombotic therapy (DAT) with single ...

Rg1-Loaded Tetrahedral DNA Nanostructures Attenuate Myocardial Ischemia-Reperfusion Injury by Suppressing Oxidative and Endoplasmic Reticulum Stress.

BACKGROUND: Myocardial ischemia-reperfusion injury (MIRI) remains a major clinical challenge in the management of acute myocardial infarction. Ginsenoside Rg1, a bioactive component from Panax ginseng...

Blood and lymphatic vascular remodeling in intervertebral disc degeneration.

A defining histological feature of the intervertebral disc (IVD) in healthy adults is its avascular and alymphatic status, which is closely related to its mode of nutrient supply and local immune home...

Adjunctive middle meningeal artery embolization with low-viscosity liquid embolic agents for acute epidural hematoma: technical considerations and a case series.

OBJECTIVE: To assess the feasibility, safety, and short-term outcomes of adjunctive middle meningeal artery (MMA) embolization using low-viscosity liquid embolic agents (1:1 diluted Onyx/DMSO and 1:9 ...

Bovine serum albumin sensitizes the mouse brain to lipopolysaccharides.

This study examined the role of bovine serum albumin (BSA) in lipopolysaccharide (LPS)-induced brain injury. Mice were intraperitoneally injected with either LPS or LPS coupled with BSA. Brain tissues...

The impact of endurance training on reducing inflammatory markers in the cardiac tissue of methamphetamine-exposed rats.

BACKGROUND: Methamphetamine (METH) consumption has significant harmful effects on the cardiovascular system, which can be mitigated by endurance training (ET). This study aimed to investigate the effe...

Stent Retriever-Assisted Embolic Protection During Recanalization of Chronic Internal Carotid Artery Occlusion with Contralateral Carotid Stenosis: A Case Report.

BACKGROUND: Chronic internal carotid artery occlusion (CICAO) with contralateral stenosis confers high stroke risk, particularly when thrombocytopenia complicates dual antiplatelet therapy (DAPT). We ...

Systemic inflammatory and metabolic disease progression persists despite prevention of myocarditis in Isg15-deficient Coxsackievirus B3 infection.

INTRODUCTION: Type I interferon responses are critical determinants of organ-specific antiviral control and metabolic adaptation during Coxsackievirus B3 (CVB3) infection. The interferon-stimulated ge...

Changes in vascular structure and function in primary hyperparathyroidism: a systematic review and meta-analysis.

INTRODUCTION: Cardiovascular (CV) diseases, particularly ischemic heart disease and stroke, remain the leading cause of mortality worldwide and constitute a major global health challenge. Primary hype...

Findings from the RAW Study: a narrative review of postoperative complications, patient factors, venous resection, and adjuvant treatment.

This review synthesizes the findings of the four studies derived from the Recurrence After Whipple's (RAW) project, which examine postoperative complications, patient-related factors, surgical techniq...

The relation between physical activity and cardiac autonomic dysfunction in patients with chronic obstructive pulmonary disease.

BACKGROUND: Cardiac autonomic dysfunction is common in patients with chronic obstructive pulmonary disease (COPD). Although exercise training improves cardiac autonomic function, the effects of changi...

Microglial immunosurveillance after ischemic stroke: dynamic phenotypes, neurovascular interactions, and therapeutic opportunities.

Ischemic stroke induces complex neuroimmune responses that extend beyond acute neuronal injury and involve dynamic interactions among microglia, the neurovascular unit, and peripheral immune cells. Mi...

Role of connexin 43 in hyperoxia-induced bronchopulmonary dysplasia and associated pulmonary hypertension.

Premature infants frequently require oxygen supplementation due to lung immaturity, exposing them to the risk of bronchopulmonary dysplasia (BPD), a chronic lung disease characterized by arrested alve...

A Retrospective Analysis of 581 Cases of Esophagogastric Variceal Bleeding Complicated by Portal Vein Thrombosis at a Single Center.

BACKGROUND: Esophagogastric variceal bleeding (EGVB) and portal vein thrombosis (PVT) are common complications of liver cirrhosis and frequently coexist, with reported prevalence rate up to 32.5%. The...