Anatomical variations of the posterior inferior cerebellar artery.
BACKGROUND: The aim of the present study was to characterize the anatomy of the posterior inferior cerebellar artery (PICA) in a Polish Caucasian population by assessing its presence, origin pattern, ...
Morphometric variability of the femoral artery access window in relation to profunda femoris artery origin: a cadaveric study with clinical implications for femoral vascular access.
BACKGROUND: The femoral artery (FA) is a key site for femoral vascular access, but the length of the arterial segment available for access may vary with the level of profunda femoris artery (PFA) orig...
Lycorine Attenuates Cardiac Fibrosis Through the Regulation of PYK2 Expression and Activity.
Lycorine (LYC), the most abundant monomeric compound from Lycoris radiata bulbs, possesses a range of biological activities, including antipulmonary fibrosis and cardioprotective effects. However, its...
Integrating Single-Cell Transcriptomics and Mendelian Randomization to Identify RAC1 as a Causal Metabolic Driver of Pericyte Dysfunction in Systemic Sclerosis.
BACKGROUND: Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular injury and progressive fibrosis. Although microvascular injury is an inciting event and pericytes are recognized...
[Endovascular closure of a large intrahepatic portosystemic shunt in a 3-month-old infant: the first case in Uzbekistan and literature review].
Congenital portosystemic shunts (CPSS) are rare vascular anomalies with portal blood bypassing hepatic filtration and subsequent various metabolic and developmental complications. Early diagnosis and ...
[Autovenous redo carotid artery replacement for restenosis of biological prosthesis in a field hospital at the special military operation zone].
A 40-year-old men received a shrapnel wound of the neck with common carotid artery rupture on the left in 2023. Carotid artery replacement with a diepoxy-treated biological prosthesis was performed. A...
[Comprehensive left ventricular outflow tract reconstruction in hypertrophic cardiomyopathy].
OBJECTIVE: To describe the concept of comprehensive left ventricular outflow tract reconstruction based on eliminating all obstructive mechanisms. MATERIAL AND METHODS: The authors analyzed own experi...
The ARGO dataset: Annotated and delineated intracardiac electrograms of post-ischemic ventricular tachycardia.
The identification of abnormal ventricular potentials (AVPs) in intracardiac electrograms of post-ischemic ventricular tachycardia patients is challenging, and the development of automated tools is ha...
Blood vessels as primary site of rejection in murine lung transplantation.
Survival after lung transplantation lags that of other solid organ transplants. Long-term survival is hampered primarily due to chronic lung allograft dysfunction (CLAD) development. It remains elusiv...
Case Report: successful non-surgical management of massive isolated tricuspid Libman-Sacks endocarditis in a pregnant patient with SLE and secondary APS.
BACKGROUND: Isolated tricuspid valve Libman-Sacks endocarditis (LSE) is extremely rare, and its occurrence during pregnancy with severe thrombocytopenia poses major diagnostic and therapeutic challeng...
Biomolecular mechanisms of cardiac amyloidosis and its cardiovascular pathological basis.
Cardiac amyloidosis (CA) is a progressive infiltrative cardiomyopathy most commonly caused by transthyretin (ATTR) or immunoglobulin light chain (AL) amyloid deposition in the myocardium, microvascula...
Hydrogels in Neurological Disorders: Emerging Diagnostic and Therapeutic Applications.
The clinical management of neurological disorders remains a major challenge worldwide, constrained by fundamental limitations in both diagnosis and therapy. Electroencephalography (EEG), the cornersto...
Plant-Derived Exosome-Like Nanoparticles in Neurodegenerative Diseases: From Dual Bioactive-Delivery Roles to Translational Challenges.
Neurodegenerative diseases, particularly Alzheimer's disease (AD) and related disorders, remain difficult to treat because of their multifactorial pathogenesis, limited disease-modifying therapies, an...
Nanotechnology-Driven Drug-Delivery Systems: Mechanistic Insights for Pediatric Autism Treatment in 2026.
Autism spectrum disorder (ASD) is a diverse neurodevelopmental disorder that commences in early childhood, characterized by enduring social-communication challenges, limited interests, and behavioral ...
Cardiac and aerobic response to growth hormone therapy in children with short stature: a prospective study using VO(2)max and speckle tracking echocardiography.
INTRODUCTION: Recombinant human growth hormone (r-hGH) enhances somatic growth and body composition, yet its short-term effects on aerobic capacity and myocardial function remain unclear in short-stat...
Elastin Regulates Vascular Smooth Muscle Cell Behavior During Development and in Diseases.
Elastic fibers are crucial components of the vessel wall. They modulate the elasticity of arteries to enable a stable blood supply to peripheral organs. Vascular smooth muscle cells (VSMCs) are anothe...
Neurovascular coupling and energy substrate delivery in Alzheimer's disease.
The brain has exceptionally high metabolic demands and depends on a continuous supply of oxygen and glucose to maintain neuronal activity and cognitive function. Despite accounting for only about 2 % ...
Starved synapses: Gut microbiome dysbiosis and its role in Alzheimer's glucose impairment.
Alzheimer's disease (AD) is increasingly recognised as a multifactorial disorder driven by metabolic, microbial, and neuroinflammatory imbalances. The study of the research results proposes that gut d...
Does resistance training make a difference to the quality of life or heart health for older adults compared to aerobic exercise? A systematic review protocol from The People's Review.
BACKGROUND: Systematic reviews bring together all the evidence on a health topic in an organised and careful way. The People's Review aims to help the public understand what systematic reviews are and...
Contribution to the pathogenesis and early diagnosis of glaucoma. A Review.
The aim of the work is to summarize recent observations on the pathogenesis of glaucoma, both from animal experiments and from clinical examinations of humans suffering from pathological intraocular p...