Endothelial ferroptosis in blood-brain barrier dysfunction and neuroinflammation: mechanisms and immune-vascular crosstalk.

Ferroptosis is an iron-dependent form of regulated cell death driven by phospholipid peroxidation. In the central nervous system (CNS), most ferroptosis research has focused on neurons and glial cells...

The correlation between the atherogenic index of plasma and aortic valve calcification in the general population: a retrospective observational cohort study.

OBJECTIVE: This study aims to explore the correlation between atherogenic index of plasma (AIP) and the risk of aortic valve calcification (AVC). METHOD: This single-center retrospective cohort study ...

Co-expression of MARCKS and GSDMD pathway genes in tuberculous meningitis: a multi-omics analysis of blood-brain barrier disruption.

INTRODUCTION: Tuberculous meningitis (TBM), the most severe form of Mycobacterium tuberculosis infection, is characterized by high mortality and neurological sequelae, largely attributed to blood-brai...

Neurocardiac consequences of traumatic brain injury: integrating neuroimmune, autonomic, and cerebrovascular mechanisms.

Traumatic brain injury (TBI) is increasingly recognized as a systemic disorder with consequences that extend beyond the central nervous system (CNS) to include clinically relevant cardiac dysfunction....

Immunogenetic modulation of endothelial inflammation by the LIPG -384A/C promoter variant influences COVID-19 severity.

BACKGROUND: Severe COVID-19 is characterized by dysregulated host immune responses and immune-mediated endothelial injury, culminating in microvascular dysfunction and systemic inflammation. Endotheli...

Integrative plasma proteomics and myeloid- interferon profiling reveal an AI-validated vascular- endothelial stress signature distinguishing SLE flare from remission in an Indian cohort a discovery - phase study.

BACKGROUND: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disorder characterized by unpredictable flares and variable clinical quiescence. Despite validated clinical indices like th...

Ultrasound-Based SECURED Protocol for Central Venous Catheterization: A Feasibility Study.

BACKGROUND: Central venous catheterization (CVC) is essential for managing critically ill patients but is associated with potential mechanical complications. Although ultrasound-guided (USG) CVC is wi...

Extracellular vesicle signalling in perioperative neurocognitive disorders.

Perioperative neurocognitive disorders (PND), including postoperative delirium, delayed neurocognitive recovery, and postoperative neurocognitive disorder, are important complications in older and vul...

Microglia-vascular interactions after spinal cord injury: regulatory mechanisms and therapeutic advances.

The repair process following spinal cord injury (SCI) involves intricate crosstalk between neuroimmune and vascular systems, with microglia-vascular interactions increasingly recognized as an importan...

Engineering Nanocarriers for Dopamine Stabilization and Targeted Brain Delivery: Mechanisms, Approaches and Translational Challenges.

Dopamine plays a central role in motor control, cognition, reward signaling, and neuroendocrine regulation, and its dysregulation is strongly associated with neurological disorders such as Parkinson's...

Robotic surgery for median arcuate ligament syndrome: technical aspects and imaging correlation.

BACKGROUND: Median arcuate ligament syndrome (MALS) is an uncommon condition characterized by chronic and intermittent abdominal pain, typically postprandial, and weight loss, caused by extrinsic comp...

The relationship between in-hospital mortality and Naples prognostic score in patients undergoing tricuspid valve surgery.

OBJECTIVE: Predicting in-hospital mortality rates following tricuspid valve surgery is imperative, especially in light of the recent advancements in treatment modalities. The Naples prognostic score s...

Clinical impact of the angiosome concept: is it applicable in femoropopliteal bypasses, limb salvage, and wound healing in critical pathologic limb-threatening ischemia?

INTRODUCTION: The global burden of peripheral artery disease is increasing worldwide. A subset of 5% of these patients ultimately reach the final stage with trophic defects, a condition clinically def...

Endothelial barrier disorder in hereditary angioedema: molecular mechanisms and therapeutic implications.

Hereditary angioedema (HAE) is a rare genetic disorder characterized by recurrent episodes of vascular leakage and tissue swelling. Although excessive bradykinin generation has long been considered th...

Electroacupuncture alleviates myocardial ischemia-reperfusion injury by targeting and inhibiting NLRP3 inflammasome-mediated cardiomyocyte pyroptosis via serum exosomal miR-22-3p.

BACKGROUND: Myocardial ischemia-reperfusion injury (MIRI) presents a significant challenge to the effectiveness of reperfusion therapy in severe ischemic heart disease. One of the core pathological me...

The influence of lean and fat mass on vascular structure and function in youth of varying body mass index percentiles- a comprehensive approach.

OBJECTIVE: The aim of this study was to compare and evaluate the relationship between body composition and arterial function among youth throughout a range of body mass index (BMI) percentiles. METHOD...

The Prognostic Value of Different Patterns of Neoatherosclerosis and Treatment Modality in Patients With Coronary In-Stent Restenosis.

BACKGROUND: Neoatherosclerosis (NA) and treatment modality may influence outcomes in patients with in-stent restenosis (ISR). This study evaluated the prognostic impact of different NA patterns and pe...

IRX3 depletion promotes early cardiac commitment of hiPSC-Derived Cardiomyocytes.

Generating mature human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) remains a major obstacle to accurate disease modeling and cardiac repair. As the transcription factor Irx3 is a...

Transcatheter and surgical aortic valve replacement for aortic stenosis in France: Trends from 2010 to 2022 and impact of European guidelines and clinical trial results.

BACKGROUND: The PARTNER trials played a key role in the expansion of transcatheter aortic valve replacement (TAVR) for severe aortic valve stenosis (AS), shaping international practice guidelines. We ...

Comparative morphology and morphometry of the right and left atrial appendages using multidetector computed tomography: an age- and sex-based analysis.

BACKGROUND: This study aimed to comparatively evaluate the morphological and morphometric characteristics of the right atrial appendage (RAA) and left atrial appendage (LAA) in the same individuals us...