Invisible threats of microplastics induced toxicity: Oxidative and inflammatory pathways in the CNS and retina.
The global spread of microplastics has become a serious public health concern. Once thought to be inert, microplastics are now recognized as biologically active agents capable of accumulating in the b...
Pilot analysis of protein profile alterations in plasma and aortic tissue of spontaneously hypertensive rats.
The role of proteins in cellular activity has received close attention. Proteome analysis can detect early enough changes in the cell before the appearance of pathological changes. Due to the increasi...
The interplay between neuroinflammation and endothelial dysfunction in cerebral small vessel disease.
Cerebral small vessel disease (CSVD) is a leading cause of ischemic stroke and vascular cognitive impairment. Despite well-defined neuroimaging features and a substantial clinical burden, the underlyi...
Physiological strategies for brain delivery.
The blood-brain barrier (BBB) remains an obstacle to treat neurological diseases, prompting the development of delivery strategies to target therapies to the brain. Receptor-mediated transport has bec...
Association of Brachial-Ankle pulse pressure with coronary artery stenosis severity: A sex-specific cross-sectional study in Chinese adults.
OBJECTIVES: To investigate the association between brachial and ankle pulse pressure and the severity of coronary artery stenosis, as well as to explore sex-specific differences in these associations....
Efferocytosis in heart failure: Mechanisms, dysregulation and therapeutic potential.
Heart failure (HF) remains one of the leading health problems globally. It is often characterized by unresolved inflammation, adverse cardiac remodeling, and tissue damage. Efferocytosis, the process ...
Balloon pressure monitoring for radial artery hemostasis after transradial coronary procedures: protocol for a randomized controlled trial.
BACKGROUND: Forearm radial artery occlusion (RAO) is a common complication after transradial coronary procedures. Traditional patent hemostasis, relying on operator-dependent assessment, results in la...
Platelet extravasation in the microvasculature: an under-appreciated role for platelets.
In recent years, evidence has accumulated highlighting the presence and role of platelet extravasation - wherein platelets accumulate in tissue parenchyma - at a variety of sites throughout the body. ...
Comparative Analysis of Two Strategies for Iliac Vein Stenting: Thrombus Clearance-Assisted Versus Direct Stenting.
BackgroundThis study aimed to compare the efficacy of mechanical thrombus clearance combined with stenting versus direct stenting alone in patients with iliofemoral venous disease,, and to analyze the...
Role of macrophages in testis function.
The testis is a unique organ that simultaneously supports spermatogenesis and steroidogenesis, and it must maintain host defense against infection while suppressing excessive immune responses in an en...
Ruptured Vertebral Artery Aneurysm in a Patient with Loeys-Dietz Syndrome Type 4: A Sentinel Case Report.
Loeys-Dietz Syndrome (LDS) is a rare, autosomal dominant connective tissue disorder with an estimated prevalence of less than 1 in 100,000. LDS results from one of several genetic mutations altering t...
Metabolomics-constrained modelling reveals dominant oxidative metabolism in the Egyptian fruit bat myocardium.
AIM: The present study aimed to elucidate which pathways contribute to cardiometabolic adaptation in Egyptian fruit bats. METHODS: Utilising cardiac tissues from Egyptian fruit bats (Rousettus aegypti...
Multimodal Radiomics Model Combining HR-VWI and Clinical Features for Identifying Symptomatic Basilar Atherosclerotic Plaques.
OBJECTIVE: This study is aimed at exploring the value of a high-resolution vessel wall imaging (HR-VWI)-based radiomics approach for identifying symptomatic basilar atherosclerotic plaques. MATERIALS ...
Pre-Therapeutic Vascular Anatomical Evaluation in Penetrating Cerebrovascular Injuries: Insights from Two Cases.
Penetrating cerebrovascular injuries (PCVIs) are often life-threatening, with trauma to the carotid or vertebral arteries potentially causing severe neurological deficits. This study aimed to retrospe...
The immune-endothelial axis in neurovascular pathophysiology: a framework for targeted interventions.
The cerebrovascular endothelium has been reconceptualized from a mere passive barrier to an active regulator of neuroimmune responses. The interaction between immune cells and endothelial cells, parti...
Endoscopic Endonasal Approach to Identify the Medial Corridor of the Cavernous Sinus: A Cadaveric Study with Clinical Correlation.
AIM: To define the existence and precise anatomical boundaries of the medial corridor (MC) within the cavernous sinus (CS), using an endoscopic endonasal transsphenoidal approach, and to correlate the...
Effective Transcatheter Mitral Valve Repair for Reverse Remodeling in Cancer Therapy-Related Cardiac Dysfunction.
Cancer therapy-related cardiac dysfunction (CTRCD) is an emerging disease. As there is no specific treatment for CTRCD, the standard therapy for cardiac failure is typically administered. In patients ...
TIF1β Promotes Myocardial Ischemia-Reperfusion Injury by Stabilizing TRAF6 through Mediating TRAF6 SUMOylation.
Myocardial ischemia-reperfusion injury (MIRI) exacerbates myocardial damage, resulting in a further decline in heart function. Abnormally high TRAF6 expression was reported in MIRI. However, what actu...
Finerenone Attenuates Myocardial Fibrosis and Pyroptosis in Rats with Myocardial Infarction.
The mineralocorticoid receptor (MR) plays a pivotal role in cardiovascular diseases, and its overactivation contributes to heart failure (HF) progression. Finerenone (FIN), a novel nonsteroidal MR ant...
Single-session photon-counting CT protocol for simultaneous screening of coronary and carotid artery disease and lung pathology.
Preventive imaging for cardiothoracic risk is fragmented across separate pathways. Photon-counting CT (PCCT) may consolidate coronary, aortic-carotid, and pulmonary assessment into a single session wh...