Integrated Network Pharmacology and Experimental Validation Approach to Systematically Elucidate the Cardioprotective Mechanisms of Shengmai Injection.
Core to advancing the study of traditional Chinese medicine (TCM) mechanisms is the integrated "computational prediction-experimental verification" strategy, which enables the precise identification o...
An Improved Brain-Penetrating Nanoformulation of the VIPR2 Antagonist Peptide KS-133 for Treating Cognitive Impairment in Schizophrenia.
In 2024, we reported a brain-penetrant formulation of the vasoactive intestinal peptide receptor 2 (VIPR2) antagonist peptide KS-133 that mitigated cognitive dysfunction in the VIPR2 hyperactivation m...
Role and mechanism of nitric oxide-regulated cGAS/STING pathway-mediated inflammatory response in hypoglycemia-induced coronary artery endothelial cell injury.
BACKGROUND: Hypoglycemia in diabetes markedly increases the risk of coronary artery events, but the mechanism by which it damages vascular endothelium through nitric oxide (NO) regulation of innate im...
Systemic lupus erythematosus-driven accelerated atherosclerosis: the immune-metabolic-vascular axis and therapeutic implications.
Patients with systemic lupus erythematosus (SLE) are at markedly increased risk of premature atherosclerosis (AS) and atherosclerotic cardiovascular disease (ASCVD), and this excess risk is not fully ...
Gut microbiota-induced elevation of succinate exacerbates diabetic myocardial ischemia/reperfusion injury by promoting macrophage polarization.
INTRODUCTION: Patients with diabetes exhibit increased susceptibility to myocardial ischemia/reperfusion (IR) injury. Emerging evidence highlights gut microbiota-derived microbial metabolites as criti...
Novel right-angled origin and severe tortuosity of the right subclavian artery: a previously unrecognized challenge in transradial access.
BACKGROUND: The right subclavian artery typically originates from the lateral wall of the brachiocephalic trunk without tortuosity. Its anatomical variations pose significant challenges during transra...
In vivo immune engineering via mRNA therapeutics: reprogramming the post-infarction cardiac microenvironment.
Myocardial infarction (MI) initiates a biphasic immune response, which plays a critical role in determining whether the heart undergoes adaptive repair or progresses to pathological fibrosis. Traditio...
Implications of systolic pulmonary artery pressure trajectories in systemic lupus erythematosus-associated pulmonary hypertension: a CSTAR-PAH cohort study.
OBJECTIVE: To identify the evolution trajectory of systolic pulmonary artery pressure (sPAP) in patients with systemic lupus erythematosus-related pulmonary arterial hypertension (SLE-PAH) and to eval...
Pinolenic Acid Inhibits Prostanoid TP Receptor-Mediated Contraction in Porcine Coronary Arteries.
Pinolenic acid (PA), an 18 : 3 n-6 polyunsaturated fatty acid abundant in pine nut oil, is a structural isomer of γ-linolenic acid (GLA) and α-linolenic acid (ALA). Notably, GLA and ALA have been repo...
Predictors of difficult vascular access during transradial neurointervention: a retrospective study.
OBJECTIVE: The aim of this study was to identify factors associated with difficulty in establishing vascular access during the transradial approach for neurointerventional therapy. METHODS: We retrosp...
Amniotic epithelial cells enhance islet engraftment by suppressing early inflammation in intraportal transplantation.
Amniotic epithelial cells (AECs) have immunomodulatory and anti-inflammatory properties that may improve outcomes in cell transplantation. However, their effect on islet engraftment after intraportal ...
Widefield SS-OCTA-detected retinal vascular changes and their correlation with DME in diabetes.
PURPOSE: This study investigated retinal blood flow alterations in diabetic macular edema (DME) using ultra-widefield optical coherence tomography angiography (OCTA). METHODS: We enrolled 31 healthy c...
Cellular expression domains of type 3 deiodinase in the meninges, choroid plexus, tanycytes and barrier tissues of the brain.
Thyroid hormone is required for brain development but under constraint because its unregulated action can damage target tissues. Type 3 deiodinase, a thyroid hormone-degrading enzyme encoded by Dio3, ...
Reappraisal of a historical porfimer sodium photodynamic therapy study for vascular restenosis: Efficacy, high procedural mortality, and methodological insights from a rabbit balloon-injury model.
BACKGROUND: Restenosis driven by intimal hyperplasia remains a major limitation of peripheral arterial intervention. Photodynamic therapy (PDT) using porfimer sodium (Photofrin®) demonstrated promisin...
Lactate and Lactylation in Pulmonary Hypertension: Comprehensive Landscape and Future Perspectives.
Pulmonary hypertension (PH) is a progressive pulmonary vascular disease with a poor prognosis and limited treatment options. Emerging evidence suggests that metabolic reprogramming plays a central rol...
PFKFB3 Mediated Glycolytic Reprogramming Drives Vascular Endothelial Injury Under Chronic Intermittent Hypoxia.
Metabolic-inflammatory crosstalk is a hallmark of cardiovascular pathogenesis. Obstructive sleep apnea (OSA), characterized by chronic intermittent hypoxia (CIH), is an independent risk factor for car...
Overcoming Biological Barriers: A Comprehensive Review of Advanced Melatonin Delivery Systems for Therapeutic Applications.
Melatonin is a pleiotropic hormone with well-documented antioxidant, anti-inflammatory, neuroprotective, and immunomodulatory properties, making it a promising candidate for the treatment of diverse d...
The Origin and Application of Cardiomyocyte-Derived Small Extracellular Vesicles: A Systematic Review.
UNLABELLED: Background/Aims: Cardiomyocyte-derived small extracellular vesicles (CM-sEVs) have emerged as important mediators of intercellular communication in cardiovascular diseases (CVDs). However,...
Neuroimmune cross-talk in Leptospira-associated acute encephalopathy syndrome.
The Leptospira-associated acute encephalopathy syndrome (AES) is a severe neurological complication, largely affecting the endemic regions. Unlike other classical neurotropic infections, Leptospira-in...
VSMCs and the immune microenvironment: a multidimensional regulatory network driving vascular injury and repair.
The dynamic interplay between vascular smooth muscle cells (VSMCs) and the immune microenvironment governs vascular repair and disease progression. This review systematically elucidates this multidime...