STIM1-dependent treg dysfunction promotes cardiometabolic HFpEF: insights from patients and animal studies.

BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) arises from chronic cardiometabolic and vascular stress and is increasingly recognized as an inflammatory syndrome with immune dysreg...

Prognostic value of baseline and longitudinal changes in exercise capacity and quality of life in the HF-Wii Swedish population.

UNLABELLED: This study aimed to explore whether baseline values and 12-month change in the 6-Minute Walk Distance (6MWD) and the physical scale of the Minnesota Living with Heart Failure Questionnaire...

The Real-World Use of Guideline-Directed Medical Therapy in Patients with Heart Failure with Reduced Ejection Fraction Newly Initiated on Dapagliflozin: An EVOLUTION-HF CEE-BA Study (Results from the Baltic Cohort).

Background and Objectives: Guideline-directed medical therapy (GDMT) remains a challenge due to its low rates worldwide. Adherence to GDMT in patients with heart failure (HF) and reduced ejection frac...

Reduced Geriatric Nutritional Risk Index Is Associated with Prevalent Diabetes Mellitus and In-Hospital Mortality in Patients Hospitalized with Heart Failure.

Background: Malnutrition is increasingly recognized as an important determinant of prognosis in patients with heart failure (HF). The Geriatric Nutritional Risk Index (GNRI) is a simple nutritional as...

Yiqi Fumai Lyophilized Injection for Improving Exercise Tolerance in Chronic Heart Failure: Protocol for a Prospective Cohort Study.

BACKGROUND: High mortality and prevalence rates are hallmarks of chronic heart failure (CHF). Patients frequently have a much lower quality of life as a result of diminished exercise tolerance. Chines...

Low-Frequency Components of the Heart Sound Corresponding to the Fourth Heart Sound Phase, Assessed by Phonocardiography, Correlate with Early Variations in Echocardiographic Indices Related to Diastolic Function.

Background and Objectives: The fourth heart sound (S4) is a recognized marker of left ventricular (LV) diastolic dysfunction, suggesting a potential risk of congestive heart failure (CHF). However, lo...

Patients' Experiences of Nurse-Led eHealth Interventions for Chronic Heart Failure: Qualitative Systematic Review and Meta-Synthesis.

BACKGROUND: Chronic heart failure (CHF) is a major chronic condition in the context of global population aging and is associated with high prevalence, frequent rehospitalization, and high mortality. S...

Identifying risk individuals for heart failure diagnosis within two years in the adult population in southern Sweden using gender, age, multimorbidity level, and socioeconomic status.

BACKGROUND: Heart failure (HF) is a common disease among older individuals and is associated with poor quality of life and prognosis. Individuals at risk of developing HF are usually already patients ...

Device therapies in cardiorenal syndrome: an expert review.

Managing cardiorenal syndrome in acute decompensated heart failure remains a major challenge in contemporary cardiology. While pharmacological decongestion with diuretics is the cornerstone of therapy...

Severe tricuspid regurgitation: aetiology, patient characteristics, and treatment: a multicentre, prospective registry.

BACKGROUND AND AIMS: Severe tricuspid regurgitation (TR) is associated with increased mortality and hospitalizations for heart failure (HF). Aetiologies of TR include: secondary (atrial or ventricular...

The HFpEF-ABA score predicts adverse cardiac remodelling and incident heart failure: a UK biobank study.

INTRODUCTION: The HFpEF-ABA score (age, body mass index, atrial fibrillation) was originally derived to diagnose heart failure with preserved ejection fraction (HFpEF) in symptomatic patients. However...

Heart failure promotes gingival inflammation and impairs periodontal remodeling.

Observational studies suggest an association between impaired oral health and cardiovascular disease; however, the directionality and underlying mechanisms remain unclear. In particular, whether heart...

Myocarditis as the first sign of SLE: a case report and review of the literature.

Lupus myocarditis (LM) is a rare but potentially life threatening manifestation of systemic lupus erythematous (SLE). LM may be rarely the initial presentation of SLE or ma y be presented during the c...

Assessment of aortic insufficiency during Impella support as a bridge to durable left ventricular assist device implantation and its long-term progression.

Impella is increasingly used as a bridge to durable left ventricular assist device (dLVAD) implantation in patients with advanced heart failure. However, Impella support may worsen aortic insufficienc...

Diagnostic Tests for Stage B Heart Failure.

PURPOSE OF THE REVIEW: To provide an overview of diagnostic tests for Stage B heart failure (SBHF), synthesizing evidence from guidelines and clinical studies. RECENT FINDINGS: Advances in diagnostic ...

Metabolomic Lipid Profile Changes in Patients with Heart Failure Undergoing Oral Nutritional Supplements Enriched with the Omega-3 (n-3) Polyunsaturated Fatty Acids and Mediterranean Diet.

UNLABELLED: Chronic inflammation and metabolic dysregulation of heart failure (HF) often result in sarcopenia. The combined effect of Mediterranean diet (MD) and omega-3 polyunsaturated fatty acids on...

Therapeutic strategies of traditional Chinese medicine for chronic heart failure: from active ingredients to herbal formulations.

Chronic heart failure (CHF) remains a global health challenge with complex pathological mechanisms, including inflammation, oxidative stress, mitochondrial dysfunction, myocardial remodeling, ferropto...

Iron deficiency in primary care patients with heart failure: a cross-sectional study of the heart failure in Southern Sweden (HISS) cohort.

BACKGROUND: Iron deficiency is a common and clinically relevant comorbidity in heart failure, associated with reduced functional capacity, higher symptom burden, and increased hospitalisation risk. Mo...

Factors associated with the implementation of advance care planning among nurses caring for patients with heart failure: A cross-sectional survey in Japan.

BACKGROUND: Multiple barriers and facilitators affect nurses' implementation of advance care planning for patients with heart failure. However, differences in nurses' perceptions according to their ex...

Out-of-pocket costs and catastrophic health expenditure among hospitalised patients with heart failure in northern Tanzania, May-October 2024: a cross-sectional study.

OBJECTIVES: To quantify out-of-pocket (OOP) costs and catastrophic health expenditure (CHE) among patients hospitalised with heart failure (HF) and to identify factors associated with CHE during a sin...