Ironing Out the Details: Advancing Diagnosis and Treatment of Iron Deficiency in Patients with Heart Failure with Preserved Ejection Fraction - A Narrative Review.

Iron deficiency (ID) is a highly prevalent and clinically significant comorbidity in heart failure with preserved ejection fraction (HFpEF), affecting 40-60% of patients. Independent of anemia, ID is ...

Beyond clinical congestion in acute heart failure: integrating lung ultrasound, venous doppler, and echocardiographic hemodynamics for imaging-guided decongestion.

Acute heart failure (AHF) is a major cause of hospitalisation worldwide and remains associated with substantial early rehospitalisation and short-term mortality. Accurate assessment of congestion rema...

Mitochondrial ncRNAs: From Pathological Regulation to Targeted Therapy in Cardiovascular Diseases.

Heart failure (HF) is closely linked to mitochondrial dysfunction, featured by abnormal energy metabolism, excessive reactive oxygen species (ROS), and imbalanced mitochondrial dynamics. Clinically, e...

Thyroid function and outcomes in heart failure with mildly reduced ejection fraction: insights from a large, retrospective registry.

OBJECTIVE: This study aimed to investigate the prognostic impact of thyroid function on the outcomes of patients with heart failure with mildly reduced ejection fraction (HFmrEF). BACKGROUND: Thyroid ...

Repurposing Heart Failure Therapies in Pulmonary Arterial Hypertension: Mechanistic Rationale, Translational Evidence, and Clinical Perspectives for SGLT2 Inhibitors and Mineralocorticoid Receptor Antagonists.

Pulmonary arterial hypertension (PAH) is a progressive and life-threatening condition characterized by elevated pulmonary vascular resistance eventually causing right ventricular failure and premature...

Association Between Serum Leucine and NT-proBNP Levels in Relation to Fragmented QRS: A Multiomic Analysis of the HOZUGAWA Cohort.

BACKGROUND/OBJECTIVES: Branched-chain amino acids (BCAAs) may play a protective role in the progression of heart failure; however, controversial results also exist. This study investigates the associa...

Exploring Targets for Heart Failure Using Mendelian Randomization, Colocalization, Summary Data-based Mendelian Randomization, and Drug Prediction.

Heart failure (HF) is a prevalent cardiovascular disease that significantly impairs quality of life in its advanced stages. Despite a variety of current treatment strategies, the disease burden of HF ...

A Mobile Health Platform for Heart Failure Self-Management: Feasibility Study on Patient Engagement, Acceptance, and Potential Health Outcomes.

BACKGROUND: Heart failure is a chronic condition that significantly impacts patients' quality of life and increases health care burden. Effective self-monitoring and lifestyle modification are essenti...

Rapid progression of cardiovascular-kidney-metabolic syndrome drives accelerated frailty trajectories: A longitudinal cohort study.

The impact of dynamic cardiovascular-kidney-metabolic (CKM) syndrome progression on longitudinal frailty trajectories remains unclear. This study investigated how rapid CKM worsening influences advers...

The association of obstructive sleep apnea with the frailty index in individuals stratified by cardiovascular-kidney-metabolic syndrome stages.

Association between obstructive sleep apnea (OSA) and frailty progression across various stages of cardiovascular-kidney-metabolic (CKM) syndrome. Data processing and analysis were performed using R v...

Mortality trends and disparities for coexisting heart failure and thyroid disease: A retrospective analysis of deaths in the United States from 1999 to 2023.

Heart failure (HF) and thyroid disease (TD) are 2 common and interacting chronic diseases, and the combined impact of comorbidity on mortality has not been fully studied. This study aims to analyze mo...

Trends in heart failure mortality among patients with rheumatoid arthritis in the United States (1999-2020): A nationwide cross-sectional analysis of the CDC WONDER database.

Rheumatoid Arthritis (RA) is a known risk factor for heart failure (HF) due to its chronic autoimmune-mediated inflammation. However, data on trends of Rheumatoid arthritis associated HF mortality in ...

Frailty index and tolerability of SGLT2 inhibitors in elderly (≥75 years) patients with heart failure.

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are cornerstone therapies for heart failure (HF), but data on tolerability in frail elderly patients (≥75 years) remain limited. This study investiga...

Cardiac remodeling in CKD: Diagnostic utility of circulating fibroblast growth factor‑23.

Left ventricular hypertrophy (LVH) is a hallmark of uremic cardiomyopathy and a strong predictor of adverse outcomes in chronic kidney disease (CKD). Conventional biomarkers often fail to capture the ...

Heart recipient outcomes following transplantation of donor hearts with impaired versus normal function: a study protocol for IMPROVED Heart, a prospective multicentre observational study.

BACKGROUND: Cardiac transplantation remains the most effective treatment for patients with end-stage heart failure, but its use is limited by donor organ shortage. Expanding donor acceptance criteria ...

Q&A with Carolyn S.P. Lam.

Professor Carolyn S.P. Lam is a senior consultant cardiologist at the National Heart Centre Singapore, where she founded Singapore's first women's heart clinic, and a tenured full professor at Duke-NU...

Heart failure with mildly reduced ejection fraction (HFmrEF): where are we now?

Heart failure (HF) with mildly reduced ejection fraction (HFmrEF), recently also termed HF with mid-range EF, describes a patient with a left ventricular ejection fraction of 40-49% (5). This classifi...

Site-specific promoter hypermethylation of GPX4 in heart failure with reduced ejection fraction (HFrEF): nonlinear dose-response with hepatic and coagulation markers.

OBJECTIVE: Heart failure with reduced ejection fraction (HFrEF) remains a major global health burden characterized by progressive cardiac dysfunction and high mortality. Emerging evidence suggests tha...

Psychological and socioeconomic impact of long-term home management on patients with left ventricular assist devices and their caregivers: a nationwide multicenter questionnaire survey.

Left ventricular assist device (LVAD) therapy requires safe long-term home management supported by patients, caregivers, and healthcare systems. In Japan, continuous caregiver availability was histori...

Sex Differences in Hypertrophic Cardiomyopathy.

PURPOSE OF REVIEW: This review summarizes contemporary evidence regarding sex-based differences in hypertrophic cardiomyopathy (HCM), including disparities in presentation, disease progression, outcom...