Psychosocial Stressors and Heart Failure Risk Among Black Women in the US.
IMPORTANCE: Black women are disproportionately susceptible to developing heart failure and display more severe morbidity and mortality compared with White women. Factors contributing to excess heart f...
[Advances in diagnosis and treatment for heart failure with preserved ejection fraction in children].
儿童射血分数保留的心力衰竭（HFpEF）病因谱复杂、表型高度异质，常与先天性心脏病、心肌病、遗传性综合征、肺动脉高压及肥胖代谢异常等因素相关，诊断和治疗均不能简单套用成人经验。近年来，年龄分层的心功能评估、心脏磁共振成像、新型生物标志物及机制导向治疗为儿童HFpEF的识别和干预提供了新思路。现围绕儿童HFpEF的诊断评估、分子病理机制及机制导向治疗进展进行综述，以期为分层诊疗和未来研究提供参考。.
[Age-stratified analysis of left ventricular ejection fraction threshold heterogeneity for heart failure with preserved ejection fraction in children].
Objective: To explore age-adapted left ventricular ejection fraction (LVEF) diagnostic thresholds for heart failure with preserved ejection fraction (HFpEF) in children. Methods: In this multicenter r...
Medicare Accountable Care Organizations: Clinical Performance for Patients With Heart Failure.
OBJECTIVES: Objective: To understand factors that distinguish higher-performing accountable care organizations (ACOs) in the Medicare Shared Savings Program from those with average levels of clinical ...
Trends and Disparities in High-Risk Nonsteroidal Anti-Inflammatory Drug Utilization.
OBJECTIVES: Regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) poses a risk to patients with chronic kidney disease (CKD), heart failure (HF), and hypertension (HTN). We evaluated changes in...
Correlation Between the High-Sensitivity C-Reactive Protein-to-Albumin Ratio and All-Cause Mortality in Patients With Acute Exacerbation of Chronic Heart Failure.
OBJECTIVE: To evaluate the correlation between the high-sensitivity C-reactive protein-to-albumin ratio (CAR) and all-cause mortality in patients with acute exacerbation of chronic heart failure (AECH...
Association Between Discharge Destination and Excess Length of Stay in Heart Failure-Related Admissions: A Retrospective Single-Centre Study.
RATIONALE: Hospital readmissions and excess inpatient length of stay remain important clinical and organisational concerns in cardiovascular care. Although discharge destination has been linked to pos...
Renal outcomes of sacubitril/valsartan compared with valsartan under triple whammy exposure in heart failure patients: A retrospective observational study.
BACKGROUND: The concurrent use of renin-angiotensin-aldosterone system (RAAS) inhibitors, diuretics, and nonsteroidal anti-inflammatory drugs (NSAIDs), known as the "triple whammy (TW)," increases the...
Dynamic Urinary Albumin/Creatinine Ratio Patterns Predict Adverse Outcomes in HFpEF: TOPCAT Cohort Analysis.
BACKGROUND: Urinary albumin-to-creatinine ratio (uACR) is a recognized cardiovascular risk marker, but its dynamic changes in heart failure with preserved ejection fraction (HFpEF) remain underexplore...
Serum Albumin Modifies the Prognostic Meaning of BNP in Acute Decompensated Heart Failure.
BACKGROUND: BNP is widely used for risk stratification in acute decompensated heart failure (ADHF), but its prognostic meaning may differ across clinical phenotypes, particularly cardiorenal syndrome ...
Sleep Circulation Time from Pulse Oximetry and Polysomnography: Predictive Value in Patients with Heart Failure with Reduced Ejection Fraction.
Background: This study evaluated the use of circulation time (Tcirc) calculated from polysomnogram (PSG) with pulse oximetry to identify poor cardiac function with low left ventricular ejection fracti...
Acute Myocarditis: From Pathophysiology to Risk-Stratified Management-A Clinical Review.
BACKGROUND: Acute myocarditis is an inflammatory disease of the myocardium with an annual incidence of 4-14 per 100,000 individuals, predominantly affecting young adults. Its clinical features are fre...
Superior Cardiorenal Protection With Tirzepatide Over Dulaglutide in Heart Failure With Preserved Ejection Fraction: A Large-Scale Propensity Score-Matched Real-World Analysis.
BACKGROUND: No direct head-to-head trials compare tirzepatide and dulaglutide in heart failure with preserved ejection fraction (HFpEF), though tirzepatide shows superior weight loss and potential car...
Development and external validation of an online interpretable machine-learning model for predicting delirium risk in acute heart failure.
ObjectiveDelirium is a frequent complication in acute heart failure and is associated with poor outcomes in the intensive care unit. Machine learning methods can leverage high-dimensional clinical dat...
Echocardiographic Phenomapping in HFpEF: From Imaging Biomarkers to Precision Cardiovascular Medicine.
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a highly prevalent and clinically heterogeneous syndrome characterized by substantial variability in pathophysiology, disease prog...
STIM1-mediated Treg instability in HFpEF: a new immunological target emerges?
Heart failure with preserved ejection fraction (HFpEF) accounts for nearly half of all heart failure cases and remains a major unmet clinical challenge. Increasing evidence supports the view of HFpEF ...
Novel Gait Speed Cut-Off Values Associated With Prognosis in Older Patients With Heart Failure.
BACKGROUND: Gait speed is an independent prognostic factor in patients with heart failure (HF) and is recognized as a therapeutic target. Although a single cutoff of 0.98 m/s has been proposed based o...
[Artificial intelligence in hypertension: where do we stand?].
Artificial intelligence (AI) is entering the study of hypertension, serving both primarily clinical purposes - to assist practicing physicians - and research objectives. Hypertension presents certain ...
Mortality Trend in Patients With Heart Failure and Psychoactive Substance Abuse in the United States-Pre- and Post-COVID-19 Pandemic Perspective (1999-2023).
BACKGROUND: This study evaluates national trends in heart failure (HF) and psychoactive substance abuse-related mortality among adults aged 25 years and older in the United States (US) from 1999 to 20...
TRIM38 Alleviates Ferroptosis in Heart Failure by Inactivating the TRAF6-p38 MAPK Pathway via Ubiquitinating Degradation of IRAK1.
This article explored the role of TRIM38 in ferroptosis in heart failure (HF) and its underlying mechanisms. Methodologically, serum TRIM38, IRAK1 and TRAF6 proteins from HF patients were detected by ...